P2RY1 - purinergic receptor P2Y1 Gene

Homo sapiens

Also known as P2Y1; SARCC

Gene ID: 5028 | Gene type: protein coding

About P2RY1

Cytogenetic location: 3q25.2 Genomic coordinates (GRCh38): 3:152,835,131-152,841,439 (from NCBI)

This gene has 1 transcript (splice variant), 191 orthologues and 15 paralogues.

Summary

The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of Phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provided by RefSeq, Jul 2008]

P2RY1 Products(1)

mRNA	Protein	Name
NM_002563.5	NP_002554.1	P2Y purinoceptor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IMP IMP: Inferred from mutant phenotype	25822790	GOA
enables G protein-coupled ADP receptor activity	IMP IMP: Inferred from mutant phenotype	9442040	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9671706	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to purine-containing compound	IMP IMP: Inferred from mutant phenotype	9442040	GOA
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9442040	GOA
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	9442040	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cilium	IDA IDA: Inferred from direct assay	28154160	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	25822790	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2RY1 Protein Structure

7tm_1

0
100
200
300
373 a.a.

Protein Preferred Names

Protein Names

P2Y purinoceptor 1

ADP receptor	ATP receptor
P2 purinoceptor subtype Y1	platelet ADP receptor
purinergic receptor P2Y, G-protein coupled, 1	suppressing androgen receptor in renal cell carcinoma

Related Diseases

Diseases

Alias

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Thrombosis

Thrombosis Of Blood Vessel

Infiltrative Basal Cell Carcinoma

Skin Infiltrating Basal Cell Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09914	P2RY1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09915	P2ry1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09916	P2ry1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	P2RY1	RGD	RGD:3242
Bos taurus	P2RY1	VGNC	VGNC:32523
Canis familiaris	P2RY1	VGNC	VGNC:44213
Macaca mulatta	P2RY1	VGNC	VGNC:75737
Felis catus	P2RY1	VGNC	VGNC:68673
Mus musculus	P2RY1	MGD	MGI:105049
Others	P2RY1	NCBI

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