SYCP3 - synaptonemal complex protein 3 Gene

Homo sapiens

Also known as COR1; SCP3; SPGF4; RPRGL4

Gene ID: 50511 | Gene type: protein coding

About SYCP3

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:101,728,648-101,739,462 (from NCBI)

This gene has 5 transcripts (splice variants), 327 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 35.2), duodenum (RPKM 4.0) and 14 other tissues.

Summary

This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

SYCP3 Products(3)

mRNA	Protein	Name
NM_001177948.2	NP_001171419.1	synaptonemal complex protein 3
NM_001177949.2	NP_001171420.1	synaptonemal complex protein 3
NM_153694.5	NP_710161.1	synaptonemal complex protein 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in sperm DNA condensation	IMP IMP: Inferred from mutant phenotype	14643120	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	22899867	GOA
located in synaptonemal complex	IDA IDA: Inferred from direct assay	9774970	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYCP3 Protein Structure

Cor1

0
100
200
236 a.a.

Protein Preferred Names

Protein Names

synaptonemal complex protein 3

SYCP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SYCP3	Q8IZU3	BLK	Homo sapiens	P51451	Anti Tag CoIP	33961781
Intra	SYCP3	Q8IZU3	BLK	Homo sapiens	P51451	Anti Tag CoIP	28514442
Intra	SYCP3	Q8IZU3	NXF1	Homo sapiens	Q9UBU9	Validated Y2H	32296183
Intra	SYCP3	Q8IZU3	C14orf119	Homo sapiens	Q9NWQ9	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spermatogenic Failure 4

Spermatogenesis Arrest	SPGF4
Azoospermia Due To Perturbations Of Meiosis	Azoospermia With Maturation Arrest
Pregnancy Loss, Recurrent, 4	Arrest Of Spermatogenesis
RPRGL4	Recurrent Pregnancy Loss 4

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation

Branchiootorenal Syndrome 2

BOR2	Bor Syndrome 2
Branchiootorenal Dysplasia 2	Branchio-Oto-Renal Dysplasia 2
Branchio-Oto-Renal Syndrome Type 2	Branchiootorenal Syndrome, Type 2

Infertility

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Gemistocytic Astrocytoma

Gemistocytic Astrocytic Tumor

Autoimmune Cardiomyopathy

Spermatogenic Failure 10

SPGF10

Spermatogenic Failure With Defective Sperm Annulus

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Oligospermia

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14072	SYCP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SYCP3	MGD	MGI:109542
Rattus norvegicus	SYCP3	RGD	RGD:3795
Bos taurus	SYCP3	VGNC	VGNC:56229

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