1. Gene
  2. SYCP3 - synaptonemal complex protein 3 Gene

SYCP3 - synaptonemal complex protein 3 Gene

Homo sapiens

Also known as COR1; SCP3; SPGF4; RPRGL4

Gene ID: 50511 | Gene type: protein coding

About SYCP3

Cytogenetic location: 12q23.2 Genomic coordinates (GRCh38): 12:101,728,648-101,739,462 (from NCBI)

This gene has 5 transcripts (splice variants), 327 orthologues, 3 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 35.2), duodenum (RPKM 4.0) and 14 other tissues.

Summary

This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2010]

SYCP3 Products(3)

mRNA Protein Name
NM_001177948.2 NP_001171419.1 synaptonemal complex protein 3
NM_001177949.2 NP_001171420.1 synaptonemal complex protein 3
NM_153694.5 NP_710161.1 synaptonemal complex protein 3
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence Reference Source
involved in sperm DNA condensation IMP
IMP: Inferred from mutant phenotype
14643120 GOA
Cellular Component GO Annotation Evidence Reference Source
located in nucleus IDA
IDA: Inferred from direct assay
22899867 GOA
located in synaptonemal complex IDA
IDA: Inferred from direct assay
9774970 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYCP3 Protein Structure

Cor1

Cor1: Cor1/Xlr/Xmr conserved region (82 - 211)

  • 0
  • 100
  • 200
  • 236 a.a.
Protein Preferred Names Protein Names

synaptonemal complex protein 3

SYCP3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SYCP3 Q8IZU3 BLK Homo sapiens P51451 33961781
Intra
SYCP3 Q8IZU3 BLK Homo sapiens P51451 28514442
Intra
SYCP3 Q8IZU3 NXF1 Homo sapiens Q9UBU9 32296183
Intra
SYCP3 Q8IZU3 C14orf119 Homo sapiens Q9NWQ9 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Spermatogenic Failure 4

Spermatogenesis Arrest

SPGF4

Azoospermia Due To Perturbations Of Meiosis

Azoospermia With Maturation Arrest

Pregnancy Loss, Recurrent, 4

Arrest Of Spermatogenesis

RPRGL4

Recurrent Pregnancy Loss 4

Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism

Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Branchiootorenal Syndrome 2

BOR2

Bor Syndrome 2

Branchiootorenal Dysplasia 2

Branchio-Oto-Renal Dysplasia 2

Branchio-Oto-Renal Syndrome Type 2

Branchiootorenal Syndrome, Type 2

Infertility
Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome

Germinal Cell Aplasia

Del Castillo Syndrome

SPGFX1

X-Linked Spermatogenic Failure 1

Congenital Absence Of Germinal Epithelium Of Testes

Gemistocytic Astrocytoma

Gemistocytic Astrocytic Tumor

Autoimmune Cardiomyopathy
Spermatogenic Failure 10

SPGF10

Spermatogenic Failure With Defective Sperm Annulus

Premature Menopause

Primary Ovarian Insufficiency

Premature Ovarian Failure

Hypergonadotropic Hypogonadism

Premature Ovarian Insufficiency

Menopause - Premature

Menopause Praecox

Menopause Premature

Menopause, Premature

Female Hypergonadotropic Hypogonadism

Hypergonadotrophic Ovarian Failure

Primary Female Hypogonadism

Pof - [Premature Ovarian Failure]

Ovarian Failure

Ovarian Secretion Suppression

Ovary Hyposecretion

Ovary Secretion Deficiency

Premature Menopause Nos

Oligospermia
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism

Undescended Testicle

Undescended Testis

Cryptorchism

Undescended Testicles

CRYPTO

Impaired Testicular Descent

Cryptosporidiosis

Retained Testis

Unilateral Cryptorchidism

Unilateral Undescended Testis

Nondescent Unilateral Testicle

Unilateral Cryptorchism

Ectopic Testis, Unilateral

Bilateral Cryptorchidism

Bilateral Cryptorchism

Bilateral Nondescent Testicle

Bilateral Undescended Testes

Bilateral Ectopic Testes

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus SYCP3 MGD MGI:109542
Rattus norvegicus SYCP3 RGD RGD:3795
Bos taurus SYCP3 VGNC VGNC:56229