PODXL2 - podocalyxin like 2 Gene

Homo sapiens

Also known as EG; PODLX2

Gene ID: 50512 | Gene type: protein coding

About PODXL2

Cytogenetic location: 3q21.3 Genomic coordinates (GRCh38): 3:127,629,185-127,672,802 (from NCBI)

This gene has 1 transcript (splice variant) and 169 orthologues. Broad expression in brain (RPKM 27.2), testis (RPKM 16.2) and 16 other tissues.

Summary

This gene is a member of the CD34 family of cell surface transmembrane proteins, which are characterized by an N-terminal extracellular Mucin domain, globular and stalk domains, a single pass transmembrane region, and a charged cytoplasmic tail. The encoded protein is a ligand for vascular selectins. [provided by RefSeq, Oct 2012]

PODXL2 Products(1)

mRNA	Protein	Name
NM_015720.4	NP_056535.1	podocalyxin-like protein 2 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18606703	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in leukocyte tethering or rolling	IDA IDA: Inferred from direct assay	18606703	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PODXL2 Protein Structure

CD34_antigen

0
100
200
300
400
500
605 a.a.

Protein Preferred Names

Protein Names

podocalyxin-like protein 2

endoglycan

Recombinant PODXL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78020	Endoglycan/PODXL2 Protein, Human (HEK293, His)	Q9NZ53-1 (G33-T500)	≥95%

Related Diseases

Diseases

Alias

Homocystinuria-Megaloblastic Anemia, Cblg Complementation Type

Methylcobalamin Deficiency, Cblg Type	HMAG
Methionine Synthase Deficiency	Methylcobalamin Deficiency Type Cblg
Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism, Cblg Complementation Type	Homocystinuria-Megaloblastic Anemia Cblg Type
Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cblg Complementation Type	Methylcobalamin Deficiency Cbl G Type
Homocystinuria Due To Defect In Methylation Cbl G	Cblg
Functional Methionine Synthase Deficiency Type Cblg	Methylcobalamin Deficiency Cblg Type
Arakawa Syndrome 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10809	PODXL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	PODXL2	VGNC	VGNC:44765
Macaca mulatta	PODXL2	VGNC	VGNC:76056
Felis catus	PODXL2	VGNC	VGNC:64275
Rattus norvegicus	PODXL2	RGD	RGD:1305815
Bos taurus	PODXL2	VGNC	VGNC:33103
Mus musculus	PODXL2	MGD	MGI:2442488
Others	PODXL2	NCBI

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