2. Gene
  3. Sirt6 - sirtuin 6 Gene

Sirt6 - sirtuin 6 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Sir2l6; mSIRT6; 2810449N18Rik

Gene ID: 50721 | Gene type: protein coding

About Sirt6

Chromosome 10: 81,457,619-81,463,631 reverse strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 193 orthologues, 6 paralogues and is associated with 54 phenotypes. Ubiquitous expression in thymus adult (RPKM 15.8), ovary adult (RPKM 15.8) and 28 other tissues.

Summary

Enables several functions, including NAD(P)+-protein-arginine ADP-ribosyltransferase activity; NAD-dependent histone deacetylase activity (H3-K9 specific); and transcription corepressor activity. Involved in several processes, including cellular protein modification process; negative regulation of nucleobase-containing compound metabolic process; and positive regulation of cell population proliferation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; gonad; musculature; and retina. Used to study progeria. Orthologous to human SIRT6 (Sirtuin 6). [provided by Alliance of Genome Resources, Apr 2022]

Sirt6 Products(4)

mRNA Protein Name
NM_181586.4 NP_853617.1 NAD-dependent protein deacylase sirtuin-6 isoform 1
NM_001378944.1 NP_001365873.1 NAD-dependent protein deacylase sirtuin-6 isoform 1
NM_001163430.2 NP_001156902.1 NAD-dependent protein deacylase sirtuin-6 isoform 2
NM_001378945.1 NP_001365874.1 NAD-dependent protein deacylase sirtuin-6 isoform 2

Sirt6 Protein Structure

SIRT7

SIRT7: cd01410 (44 - 256)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

NAD-dependent protein deacylase sirtuin-6

NAD-dependent protein deacetylase sirtuin-6

NAD-dependent deacetylase sirtuin-6

SIR2-like protein 6

protein mono-ADP-ribosyltransferase sirtuin-6

regulatory protein SIR2 homolog 6

Related Agents

Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-107454 OSS_128167 Inhibitor 98.63% Unkown
HY-115453 UBCS039 Activator 99.06% Unkown
HY-148712 SIRT6 activator 12q Activator 98.01% Unkown
HY-153104 CrBKA 98.46% Unkown
HY-169159 SIRT6 activator 2 Activator / Unkown
HY-156027 SIRT6-IN-3 Inhibitor / Unkown
HY-150727 SIRT5 inhibitor 4 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sirt6 NCBI NCBI:51548