HP1BP3 - heterochromatin protein 1 binding protein 3 Gene

Homo sapiens

Also known as HP1BP74; HP1-BP74

Gene ID: 50809 | Gene type: protein coding

About HP1BP3

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:20,740,266-20,787,307 (from NCBI)

This gene has 14 transcripts (splice variants) and 253 orthologues. Ubiquitous expression in thyroid (RPKM 36.6), endometrium (RPKM 35.9) and 25 other tissues.

Summary

Enables DNA binding activity and nucleosome binding activity. Involved in several processes, including cellular response to hypoxia; heterochromatin organization; and regulation of nucleus size. Located in chromosome and nuclear speck. [provided by Alliance of Genome Resources, Apr 2022]

HP1BP3 Products(16)

mRNA	Protein	Name
NM_001372052.1	NP_001358981.1	heterochromatin protein 1-binding protein 3 isoform 1
NM_001376787.1	NP_001363716.1	heterochromatin protein 1-binding protein 3 isoform 1
NM_001376788.1	NP_001363717.1	heterochromatin protein 1-binding protein 3 isoform 1
NM_001376789.1	NP_001363718.1	heterochromatin protein 1-binding protein 3 isoform 1
NM_001376790.1	NP_001363719.1	heterochromatin protein 1-binding protein 3 isoform 1
NM_001376791.1	NP_001363720.1	heterochromatin protein 1-binding protein 3 isoform 2
NM_001376792.1	NP_001363721.1	heterochromatin protein 1-binding protein 3 isoform 2
NM_001376793.1	NP_001363722.1	heterochromatin protein 1-binding protein 3 isoform 2
NM_001376794.1	NP_001363723.1	heterochromatin protein 1-binding protein 3 isoform 2
NM_001376795.1	NP_001363724.1	heterochromatin protein 1-binding protein 3 isoform 3
NM_001376796.1	NP_001363725.1	heterochromatin protein 1-binding protein 3 isoform 3
NM_001376797.1	NP_001363726.1	heterochromatin protein 1-binding protein 3 isoform 4
NM_001399820.1	NP_001386749.1	heterochromatin protein 1-binding protein 3 isoform 5
NM_001399821.1	NP_001386750.1	heterochromatin protein 1-binding protein 3 isoform 2
NM_001399823.1	NP_001386752.1	heterochromatin protein 1-binding protein 3 isoform 2
NM_016287.5	NP_057371.2	heterochromatin protein 1-binding protein 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	20042602	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	20042602	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20042602	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	25100860	GOA
involved in heterochromatin organization	IMP IMP: Inferred from mutant phenotype	24830416	GOA
involved in regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	24830416	GOA
involved in regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	24830416	GOA
involved in regulation of nucleus size	IMP IMP: Inferred from mutant phenotype	24830416	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromosome	IDA IDA: Inferred from direct assay	20042602	GOA
located in nucleus	IDA IDA: Inferred from direct assay	24830416	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HP1BP3 Protein Structure

Linker_histone

0
100
200
300
400
500
553 a.a.

Protein Preferred Names

Protein Names

heterochromatin protein 1-binding protein 3

HP1BP3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HP1BP3	Q5SSJ5	H2AC4	Homo sapiens	P04908	Crosslink	30021884
Intra	HP1BP3	Q5SSJ5	H2AC4	Homo sapiens	P04908	Anti Tag CoIP	33961781
Intra	HP1BP3	Q5SSJ5	MEOX2	Homo sapiens	P50222	Y2H Prey Pooling	25416956
Intra	HP1BP3	Q5SSJ5	MEOX2	Homo sapiens	P50222	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Methylmalonic Aciduria, Cblb Type

Methylmalonic Aciduria Cblb Type	Methylmalonic Acidemia Cblb Type
Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Complementation Type	Methylmalonic Acidemia, Cblb Type
Methylmalonic Aciduria, Vitamin B12-Responsive, Due To Defect In Synthesis Of Adenosylcobalamin, Cblb Type	Methylmalonic Aciduria, Vitamin B12-Responsive, Cblb Type
Vitamin B12-Responsive Methylmalonic Acidemia Type Cblb	Vitamin B12-Responsive Methylmalonic Aciduria, Type Cblb
Methylmalonic Aciduria Type Cblb	MMAB
Methylmalonic Aciduria Type B	Vitamin B12 Responsive Methylmalonic Acidemia Type Cbl B
Vitamin B12 Responsive Methylmalonic Aciduria Type Cbl B	Aciduria, Methylmalonic, Cblb Type
Methylmalonic Acidemia	Methylmalonic Aciduria

Postpartum Depression

Maternity Blues	Postnatal Depression
Depression, Postpartum	Post-Partum Depression
Depression Postpartum

Endogenous Depression

Clinical Depression	Unipolar Depression
Depressive Disorder

Cataract 34, Multiple Types

Cataract, Autosomal Recessive Congenital 3	Cataract 34 Multiple Types
CTRCT34	Catc3
Cataract 34, Multiple Types, With Or Without Microcornea	Autosomal Recessive Congenital Cataract 3
Cataract 34 Multiple Types With Or Without Microcornea	Cataract, Multiple Types, Type 34

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06332	HP1BP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	HP1BP3	VGNC	VGNC:62835
Bos taurus	HP1BP3	VGNC	VGNC:29935
Mus musculus	HP1BP3	MGD	MGI:109369
Rattus norvegicus	HP1BP3	RGD	RGD:735099
Macaca mulatta	HP1BP3	VGNC	VGNC:73440
Canis familiaris	HP1BP3	VGNC	VGNC:41767

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