2. Gene
  3. Il22 - interleukin 22 Gene

Il22 - interleukin 22 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as IL-22; If2b1; Iltif; IL-22a; ILTIFa

Gene ID: 50929 | Gene type: protein coding

About Il22

Summary

Predicted to enable cytokine activity. Acts upstream of or within several processes, including negative regulation of inflammatory response; Reactive Oxygen Species metabolic process; and regulation of tyrosine phosphorylation of STAT protein. Predicted to be located in extracellular space. Is expressed in retina and skin. Used to study liposarcoma. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL22 (interleukin 22). [provided by Alliance of Genome Resources, Apr 2022]

Il22 Products(1)

mRNA Protein Name
NM_016971.2 NP_058667.1 interleukin-22 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cytokine activity IDA
IDA: Inferred from direct assay
28811323 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12700595 MGI
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of inflammatory response IDA
IDA: Inferred from direct assay
28811323 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
23075849 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16982811 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16982811 MGI
acts upstream of or within reactive oxygen species metabolic process IDA
IDA: Inferred from direct assay
12700595 MGI
acts upstream of or within regulation of tyrosine phosphorylation of STAT protein IDA
IDA: Inferred from direct assay
12700595 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in extracellular space IDA
IDA: Inferred from direct assay
28811323 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-22

IL-10-related T-cell-derived-inducible factor

IL-TIF alpha

ILTIF alpha

interferon 2b1

interleukin 10-related T cell-derived inducible factor

interleukin-22a

Recombinant Il22 Proteins

Cat. No. Product Name Accession Purity
HY-P7079 IL-22 Protein, Mouse Q9JJY9 (L34-V179) ≥95%
HY-P72793 IL-22 Protein, Mouse (CHO) Q9JJY9 (L34-V179) ≥95%
HY-P78150 IL-22 Protein, Mouse (His-Avi) Q9JJY9 (L34-V179) ≥95%
HY-P7079A IL-22 Protein, Mouse (His) Q9JJY9 (L34-V179) ≥95%
HY-P7079AF Animal-Free IL-22 Protein, Mouse (His) Q9JJY9 (L34-V179) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99244 Fezakinumab 99.30% Phase 2
HY-P99919 Efmarodocokin alfa Activator / Phase 1
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-133552 RORγt Inverse agonist 10 Antagonist 99.13% Unkown
HY-162490 TF-S14 Inhibitor / Unkown
HY-RS06736 IL22 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06737 IL22RA1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS06738 IL22RA2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
Inhibitory Antibodies (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P990016 Temtokibart Inhibitor 99.23% Unkown
HY-P99917 Eflepedocokin alfa Activator / Unkown
HY-P990735 Donzakimig / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Il22 NCBI NCBI:50616
Canis familiaris Il22 NCBI NCBI:481153
Macaca fascicularis Il22 NCBI NCBI:102129310
Rattus norvegicus Il22 NCBI NCBI:500836