AMDHD2 - amidohydrolase domain containing 2 Gene

Homo sapiens

Also known as CGI-14

Gene ID: 51005 | Gene type: protein coding

About AMDHD2

This gene has 19 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in spleen (RPKM 8.7), kidney (RPKM 8.5) and 25 other tissues.

Summary

Enables N-acetylglucosamine-6-phosphate deacetylase activity. Predicted to be involved in N-acetylglucosamine catabolic process. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

AMDHD2 Products(4)

mRNA	Protein	Name
NM_001145815.2	NP_001139287.1	N-acetylglucosamine-6-phosphate deacetylase isoform 2
NM_001330449.2	NP_001317378.1	N-acetylglucosamine-6-phosphate deacetylase isoform 3
NM_001410943.1	NP_001397872.1	N-acetylglucosamine-6-phosphate deacetylase isoform 4
NM_015944.4	NP_057028.2	N-acetylglucosamine-6-phosphate deacetylase isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
NOT enables N-acetylgalactosamine-6-phosphate deacetylase activity	IDA IDA: Inferred from direct assay	35229715	GOA
enables N-acetylglucosamine-6-phosphate deacetylase activity	IDA IDA: Inferred from direct assay	22692205	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of UDP-N-acetylglucosamine biosynthetic process	IDA IDA: Inferred from direct assay	35229715	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMDHD2 Protein Structure

0
100
200
300
409 a.a.

Protein Preferred Names

Protein Names

N-acetylglucosamine-6-phosphate deacetylase

amidohydrolase domain-containing protein 2

AMDHD2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AMDHD2	Q9Y303	GNPDA2	Homo sapiens	Q8TDQ7	Validated Y2H	25416956
Intra	AMDHD2	Q9Y303	GNPDA2	Homo sapiens	Q8TDQ7	Y2H Prey Pooling	25416956
Intra	AMDHD2	Q9Y303	GNPDA2	Homo sapiens	Q8TDQ7	Y2H Array	29892012
Intra	AMDHD2	Q9Y303	TRIP13	Homo sapiens	Q15645	Y2H Array	25416956
Intra	AMDHD2	Q9Y303	TRIP13	Homo sapiens	Q15645	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00646	AMDHD2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AMDHD2	RGD	RGD:1304601
Mus musculus	AMDHD2	MGD	MGI:2443978

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