2. Gene
  3. TRIP13 - thyroid hormone receptor interactor 13 Gene

TRIP13 - thyroid hormone receptor interactor 13 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MVA3; OOMD9; 16E1BP

Gene ID: 9319 | Gene type: protein coding

About TRIP13

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:892,884-919,348 (from NCBI)

This gene has 7 transcripts (splice variants), 193 orthologues and is associated with 5 phenotypes. Biased expression in testis (RPKM 14.2), lymph node (RPKM 3.0) and 10 other tissues.

Summary

This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung Cancer. [provided by RefSeq, Oct 2009]

TRIP13 Products(2)

mRNA Protein Name
NM_001166260.2 NP_001159732.1 pachytene checkpoint protein 2 homolog isoform 2
NM_004237.4 NP_004228.1 pachytene checkpoint protein 2 homolog isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16169070 GOA
Biological Process GO Annotation Evidence Reference Source
involved in mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
28553959 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIP13 Protein Structure

AAA

AAA: ATPase family associated with various cellular activities (AAA) (175 - 320)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 432 a.a.
Protein Preferred Names Protein Names

pachytene checkpoint protein 2 homolog

16E1-BP

TRIP13 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TRIP13 Q15645 METTL15 Homo sapiens A6NJ78-4
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 METTL15 Homo sapiens A6NJ78-4
Validated Y2H
25416956
Intra
TRIP13 Q15645 METTL15 Homo sapiens A6NJ78-4
Y2H Array
25416956
Intra
TRIP13 Q15645 KRTAP12-2 Homo sapiens P59991
Validated Y2H
25416956
Intra
TRIP13 Q15645 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 KRTAP12-2 Homo sapiens P59991
Y2H Array
25416956
Intra
TRIP13 Q15645 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
TRIP13 Q15645 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
TRIP13 Q15645 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
TRIP13 Q15645 COMT Homo sapiens P21964-2
Validated Y2H
25416956
Intra
TRIP13 Q15645 COMT Homo sapiens P21964-2
Y2H Array
25416956
Intra
TRIP13 Q15645 QARS1 Homo sapiens P47897-2
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 QARS1 Homo sapiens P47897-2
Y2H Array
25416956
Intra
TRIP13 Q15645 KRTAP12-1 Homo sapiens P59990
Validated Y2H
25416956
Intra
TRIP13 Q15645 KRTAP12-1 Homo sapiens P59990
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 DIP2A Homo sapiens Q14689-6
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 KYAT1 Homo sapiens Q16773
Validated Y2H
25416956
Intra
TRIP13 Q15645 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
25416956
Intra
TRIP13 Q15645 FNDC3B Homo sapiens Q53EP0-3
Validated Y2H
32296183
Intra
TRIP13 Q15645 SPRYD7 Homo sapiens Q5W111
Y2H Array
25416956
Intra
TRIP13 Q15645 SPRYD7 Homo sapiens Q5W111
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 PCMTD2 Homo sapiens Q6PIM4
Y2H Array
25416956
Intra
TRIP13 Q15645 PCMTD2 Homo sapiens Q6PIM4
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 C4orf33 Homo sapiens Q8N1A6
Y2H Array
25416956
Intra
TRIP13 Q15645 C4orf33 Homo sapiens Q8N1A6
Y2H Array
31515488
Intra
TRIP13 Q15645 C4orf33 Homo sapiens Q8N1A6
Validated Y2H
25416956
Intra
TRIP13 Q15645 C4orf33 Homo sapiens Q8N1A6
Validated Y2H
32296183
Intra
TRIP13 Q15645 TINAGL1 Homo sapiens Q9GZM7-3
Validated Y2H
25416956
Intra
TRIP13 Q15645 TINAGL1 Homo sapiens Q9GZM7-3
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 TINAGL1 Homo sapiens Q9GZM7-3
Y2H Array
25416956
Intra
TRIP13 Q15645 CDIN1 Homo sapiens Q9Y2V0
Validated Y2H
32296183
Intra
TRIP13 Q15645 SCP2 Homo sapiens P22307
Y2H
21516116
Intra
TRIP13 Q15645 IGFN1 Homo sapiens Q86VF2-5
Validated Y2H
32296183
Intra
TRIP13 Q15645 PCSK5 Homo sapiens Q92824-2
Validated Y2H
32296183
Intra
TRIP13 Q15645 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra
TRIP13 Q15645 ACTMAP Homo sapiens Q5BKX5-3
Validated Y2H
32296183
Intra
TRIP13 Q15645 ASB13 Homo sapiens Q8WXK3-2
Validated Y2H
32296183
Intra
TRIP13 Q15645 ANKRD10 Homo sapiens Q9NXR5-2
Validated Y2H
32296183
Intra
TRIP13 Q15645 CYB5R2 Homo sapiens Q6BCY4-2
Validated Y2H
32296183
Intra
TRIP13 Q15645 C11orf54 Homo sapiens Q9H0W9-3
Validated Y2H
32296183
Intra
TRIP13 Q15645 KRTAP6-1 Homo sapiens Q3LI64
Complementation
32296183
Intra
TRIP13 Q15645 KRTAP6-1 Homo sapiens Q3LI64
Validated Y2H
32296183
Intra
TRIP13 Q15645 MYEOV Homo sapiens Q96EZ4
Validated Y2H
32296183
Intra
TRIP13 Q15645 AMDHD2 Homo sapiens Q9Y303-2
Validated Y2H
32296183
Intra
TRIP13 Q15645 CEP170B Homo sapiens Q9Y4F5-3
Y2H Prey Pooling
32296183
Intra
TRIP13 Q15645 CEP170B Homo sapiens Q9Y4F5-3
Validated Y2H
32296183
Intra
TRIP13 Q15645 CEP170B Homo sapiens Q9Y4F5-3
Y2H Array
32296183
Intra
TRIP13 Q15645 ZMYM5 Homo sapiens Q9UJ78-2
Validated Y2H
32296183
Intra
TRIP13 Q15645 ZMYM5 Homo sapiens Q9UJ78-2
Y2H Array
32296183
Intra
TRIP13 Q15645 ZMYM5 Homo sapiens Q9UJ78-2
Y2H Prey Pooling
32296183
Intra
TRIP13 Q15645 TPT1 Homo sapiens P13693
Validated Y2H
25416956
Intra
TRIP13 Q15645 ARSA Homo sapiens P15289
Y2H Array
25416956
Intra
TRIP13 Q15645 TNRC6A Homo sapiens Q8NDV7
Y2H Array
25416956
Intra
TRIP13 Q15645 TNRC6A Homo sapiens Q8NDV7
Validated Y2H
25416956
Intra
TRIP13 Q15645 RNF4 Homo sapiens P78317
Y2H Prey Pooling
32296183
Intra
TRIP13 Q15645 RNF4 Homo sapiens P78317
Y2H Array
32296183
Intra
TRIP13 Q15645 MPPED2 Homo sapiens Q15777
Validated Y2H
32296183
Intra
TRIP13 Q15645 MPPED2 Homo sapiens Q15777
Y2H Array
25416956
Intra
TRIP13 Q15645 LRR1 Homo sapiens Q96L50
Y2H Array
25416956
Intra
TRIP13 Q15645 LRR1 Homo sapiens Q96L50
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 AMDHD2 Homo sapiens Q9Y303
Validated Y2H
25416956
Intra
TRIP13 Q15645 QARS1 Homo sapiens P47897
Y2H Array
25416956
Intra
TRIP13 Q15645 QARS1 Homo sapiens P47897
Validated Y2H
25416956
Intra
TRIP13 Q15645 MAD2L1BP Homo sapiens Q15013
Y2H Pooling
16189514
Intra
TRIP13 Q15645 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
25416956
Intra
TRIP13 Q15645 RHOXF2 Homo sapiens Q9BQY4
Y2H Array
25416956
Intra
TRIP13 Q15645 RHOXF2 Homo sapiens Q9BQY4
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 RHOXF2 Homo sapiens Q9BQY4
Validated Y2H
32296183
Intra
TRIP13 Q15645 COMT Homo sapiens P21964
Y2H Array
19060904
Intra
TRIP13 Q15645 COMT Homo sapiens P21964
Y2H Pooling
19060904
Intra
TRIP13 Q15645 STAMBP Homo sapiens O95630
Y2H Array
31515488
Intra
TRIP13 Q15645 STAMBP Homo sapiens O95630
Y2H Pooling
19060904
Intra
TRIP13 Q15645 STAMBP Homo sapiens O95630
Y2H Array
19060904
Intra
TRIP13 Q15645 PELI1 Homo sapiens Q96FA3
Validated Y2H
25416956
Intra
TRIP13 Q15645 PELI1 Homo sapiens Q96FA3
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 CLIP4 Homo sapiens Q8N3C7
Validated Y2H
32296183
Intra
TRIP13 Q15645 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
TRIP13 Q15645 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
TRIP13 Q15645 SELENBP1 Homo sapiens Q13228
Y2H Array
29892012
Intra
TRIP13 Q15645 SELENBP1 Homo sapiens Q13228
Y2H Array
31515488
Intra
TRIP13 Q15645 PPP2CA Homo sapiens P67775
Y2H Pooling
19060904
Intra
TRIP13 Q15645 PPP2CA Homo sapiens P67775
Y2H Array
19060904
Intra
TRIP13 Q15645 TINAGL1 Homo sapiens Q9GZM7
Y2H Array
25416956
Intra
TRIP13 Q15645 TINAGL1 Homo sapiens Q9GZM7
Validated Y2H
32296183
Intra
TRIP13 Q15645 TINAGL1 Homo sapiens Q9GZM7
Validated Y2H
25416956
Intra
TRIP13 Q15645 PRKN Homo sapiens O60260
Y2H Array
19060904
Intra
TRIP13 Q15645 PRKN Homo sapiens O60260
Y2H Pooling
19060904
Intra
TRIP13 Q15645 DPYSL4 Homo sapiens O14531
Y2H Array
25416956
Intra
TRIP13 Q15645 LNX1 Homo sapiens Q8TBB1
Y2H Array
29892012
Intra
TRIP13 Q15645 LNX1 Homo sapiens Q8TBB1
Y2H Pooling
16189514
Intra
TRIP13 Q15645 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 LNX1 Homo sapiens Q8TBB1
Validated Y2H
25416956
Intra
TRIP13 Q15645 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
TRIP13 Q15645 C11orf54 Homo sapiens Q9H0W9
Y2H Pooling
19060904
Intra
TRIP13 Q15645 C11orf54 Homo sapiens Q9H0W9
Y2H Array
19060904
Intra
TRIP13 Q15645 C11orf54 Homo sapiens Q9H0W9
Y2H Pooling
16189514
Intra
TRIP13 Q15645 NIF3L1 Homo sapiens Q9GZT8
Y2H Pooling
16189514
Intra
TRIP13 Q15645 NIF3L1 Homo sapiens Q9GZT8
Y2H Array
19060904
Intra
TRIP13 Q15645 NIF3L1 Homo sapiens Q9GZT8
Y2H Pooling
19060904
Intra
TRIP13 Q15645 PRR13 Homo sapiens Q9NZ81
Y2H Prey Pooling
32296183
Intra
TRIP13 Q15645 PRR13 Homo sapiens Q9NZ81
Validated Y2H
32296183
Intra
TRIP13 Q15645 NTAQ1 Homo sapiens Q96HA8
Y2H Array
19060904
Intra
TRIP13 Q15645 NTAQ1 Homo sapiens Q96HA8
Y2H Pooling
19060904
Intra
TRIP13 Q15645 NTAQ1 Homo sapiens Q96HA8
Y2H Pooling
16189514
Intra
TRIP13 Q15645 LASP1 Homo sapiens Q14847
Y2H Array
19060904
Intra
TRIP13 Q15645 LASP1 Homo sapiens Q14847
Y2H Array
25416956
Intra
TRIP13 Q15645 LASP1 Homo sapiens Q14847
Y2H Pooling
19060904
Intra
TRIP13 Q15645 LASP1 Homo sapiens Q14847
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 SPMIP9 Homo sapiens Q96LM6
Validated Y2H
25416956
Intra
TRIP13 Q15645 SPMIP9 Homo sapiens Q96LM6
Validated Y2H
32296183
Intra
TRIP13 Q15645 SPMIP9 Homo sapiens Q96LM6
Y2H Pooling
16189514
Intra
TRIP13 Q15645 SPMIP9 Homo sapiens Q96LM6
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 CYB5R2 Homo sapiens Q6BCY4
Y2H Pooling
16189514
Intra
TRIP13 Q15645 CYB5R2 Homo sapiens Q6BCY4
Validated Y2H
25416956
Intra
TRIP13 Q15645 CYB5R2 Homo sapiens Q6BCY4
Y2H Array
25416956
Intra
TRIP13 Q15645 HDHD3 Homo sapiens Q9BSH5
Y2H Array
19060904
Intra
TRIP13 Q15645 HDHD3 Homo sapiens Q9BSH5
Validated Y2H
32296183
Intra
TRIP13 Q15645 HDHD3 Homo sapiens Q9BSH5
Y2H Pooling
19060904
Intra
TRIP13 Q15645 HDHD3 Homo sapiens Q9BSH5
Y2H Pooling
16189514
Intra
TRIP13 Q15645 MEAK7 Homo sapiens Q6P9B6
Y2H Pooling
19060904
Intra
TRIP13 Q15645 MEAK7 Homo sapiens Q6P9B6
Y2H Pooling
16189514
Intra
TRIP13 Q15645 MEAK7 Homo sapiens Q6P9B6
Y2H Array
19060904
Intra
TRIP13 Q15645 EEF2KMT Homo sapiens Q96G04
Validated Y2H
32296183
Intra
TRIP13 Q15645 GLYCTK Homo sapiens Q8IVS8
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 GLYCTK Homo sapiens Q8IVS8
Validated Y2H
32296183
Intra
TRIP13 Q15645 GLYCTK Homo sapiens Q8IVS8
Y2H Pooling
16189514
Intra
TRIP13 Q15645 DDAH2 Homo sapiens O95865
Y2H Pooling
19060904
Intra
TRIP13 Q15645 DDAH2 Homo sapiens O95865
Y2H Pooling
16189514
Intra
TRIP13 Q15645 DDAH2 Homo sapiens O95865
Y2H Array
19060904
Intra
TRIP13 Q15645 LOXL4 Homo sapiens Q96JB6
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 LOXL4 Homo sapiens Q96JB6
Y2H Pooling
16189514
Intra
TRIP13 Q15645 SIGLEC5 Homo sapiens O15389
Validated Y2H
25416956
Intra
TRIP13 Q15645 SIGLEC5 Homo sapiens O15389
Y2H Array
25416956
Intra
TRIP13 Q15645 SIGLEC5 Homo sapiens O15389
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 PBLD Homo sapiens P30039
Y2H Pooling
16189514
Intra
TRIP13 Q15645 PBLD Homo sapiens P30039
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 PLSCR3 Homo sapiens Q9NRY6
Y2H Pooling
16189514
Intra
TRIP13 Q15645 PLSCR3 Homo sapiens Q9NRY6
Validated Y2H
25416956
Intra
TRIP13 Q15645 PLSCR3 Homo sapiens Q9NRY6
Validated Y2H
32296183
Intra
TRIP13 Q15645 PLSCR3 Homo sapiens Q9NRY6
Y2H Array
25416956
Intra
TRIP13 Q15645 ARL11 Homo sapiens Q969Q4
Y2H Pooling
16189514
Intra
TRIP13 Q15645 ARL11 Homo sapiens Q969Q4
Y2H Array
31515488
Intra
TRIP13 Q15645 TENT5B Homo sapiens Q96A09
Validated Y2H
32296183
Intra
TRIP13 Q15645 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
Intra
TRIP13 Q15645 PLSCR4 Homo sapiens Q9NRQ2
Y2H Pooling
16189514
Intra
TRIP13 Q15645 PLSCR4 Homo sapiens Q9NRQ2
Complementation
32296183
Intra
TRIP13 Q15645 SEMA4G Homo sapiens Q9NTN9-3
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 SEMA4G Homo sapiens Q9NTN9-3
Y2H Array
25416956
Intra
TRIP13 Q15645 MORN3 Homo sapiens Q6PF18
Y2H Prey Pooling
25416956
Intra
TRIP13 Q15645 SHARPIN Homo sapiens Q9H0F6-2
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Oocyte Maturation Defect 9

OOMD9
Mosaic Variegated Aneuploidy Syndrome 3

MVA3

Mosaic Variegated Aneuploidy Syndrome, Type 3
Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome

Mva Syndrome

Mosaic Variegated Aneuplody Microcephaly Syndrome

Warburton Anyane Yeboa Syndrome
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
Infertility
Spherocytosis, Type 2

Hereditary Spherocytosis Type 2

SPH2

Spherocytosis, Hereditary, 2

Hs2

Hereditary Spherocytosis 2

Spherocytosis 2

Spherocytosis, Type 2, Autosomal Dominant
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-130603 DCZ0415 99.77% Unkown
HY-Q04764 TI17 ≥97.0% Unkown
HY-157331 DCZ5418 Inhibitor / Unkown
HY-162999 TRIP13-IN-1 Inhibitor / Unkown
HY-RS15079 TRIP13 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TRIP13 VGNC VGNC:36359
Canis familiaris TRIP13 VGNC VGNC:47846
Felis catus TRIP13 VGNC VGNC:66561
Rattus norvegicus TRIP13 RGD RGD:1308516
Mus musculus TRIP13 MGD MGI:1916966
Macaca mulatta TRIP13 VGNC VGNC:78648
Others TRIP13 NCBI