TRIP13 - thyroid hormone receptor interactor 13 Gene

Homo sapiens

Also known as MVA3; OOMD9; 16E1BP

Gene ID: 9319 | Gene type: protein coding

About TRIP13

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:892,884-919,348 (from NCBI)

This gene has 7 transcripts (splice variants), 193 orthologues and is associated with 5 phenotypes. Biased expression in testis (RPKM 14.2), lymph node (RPKM 3.0) and 10 other tissues.

Summary

This gene encodes a protein that interacts with thyroid hormone receptors, also known as hormone-dependent transcription factors. The gene product interacts specifically with the ligand binding domain. This gene is one of several that may play a role in early-stage non-small cell lung Cancer. [provided by RefSeq, Oct 2009]

TRIP13 Products(2)

mRNA	Protein	Name
NM_001166260.2	NP_001159732.1	pachytene checkpoint protein 2 homolog isoform 2
NM_004237.4	NP_004228.1	pachytene checkpoint protein 2 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic spindle assembly checkpoint signaling	IMP IMP: Inferred from mutant phenotype	28553959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRIP13 Protein Structure

AAA

0
100
200
300
400
432 a.a.

Protein Preferred Names

Protein Names

pachytene checkpoint protein 2 homolog

16E1-BP

Related Diseases

Diseases

Alias

Oocyte Maturation Defect 9

OOMD9

Mosaic Variegated Aneuploidy Syndrome 3

MVA3	Mosaic Variegated Aneuploidy Syndrome, Type 3

Mosaic Variegated Aneuploidy Syndrome

Warburton-Anyane-Yeboa Syndrome	Mva Syndrome
Mosaic Variegated Aneuplody Microcephaly Syndrome	Warburton Anyane Yeboa Syndrome

Wilms Tumor 1

Nephroblastoma	Wilms Tumor
WT1	Wilms' Tumor
Bilateral Wilms Tumor	Wilms Tumor, Type 1
Wilms Tumor, Somatic	Adult Nephroblastoma
Wt1 Disorder	Renal Embryonic Tumor
Adult Kidney Wilms Tumor	Childhood Kidney Wilms Tumor
Nonanaplastic Kidney Wilms Tumor

Infertility

Spherocytosis, Type 2

Hereditary Spherocytosis Type 2	SPH2
Spherocytosis, Hereditary, 2	Hs2
Hereditary Spherocytosis 2	Spherocytosis 2
Spherocytosis, Type 2, Autosomal Dominant

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-130603	DCZ0415		99.77%	Unkown
HY-Q04764	TI17		≥97.0%	Unkown
HY-157331	DCZ5418	Inhibitor	/	Unkown
HY-162999	TRIP13-IN-1	Inhibitor	/	Unkown
HY-RS15079	TRIP13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRIP13	VGNC	VGNC:36359
Canis familiaris	TRIP13	VGNC	VGNC:47846
Felis catus	TRIP13	VGNC	VGNC:66561
Rattus norvegicus	TRIP13	RGD	RGD:1308516
Mus musculus	TRIP13	MGD	MGI:1916966
Macaca mulatta	TRIP13	VGNC	VGNC:78648
Others	TRIP13	NCBI

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