2. Gene
  3. GLRX2 - glutaredoxin 2 Gene

GLRX2 - glutaredoxin 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as GRX2; CGI-133

Gene ID: 51022 | Gene type: protein coding

About GLRX2

Cytogenetic location: 1q31.2 Genomic coordinates (GRCh38): 1:193,096,465-193,106,114 (from NCBI)

This gene has 4 transcripts (splice variants), 190 orthologues and 2 paralogues. Broad expression in testis (RPKM 15.8), prostate (RPKM 7.2) and 24 other tissues.

Summary

The protein encoded by this gene is a member of the glutaredoxin family of proteins, which maintain cellular thiol homeostasis. These proteins are thiol-disulfide oxidoreductases that use a glutathione-binding site and one or two active cysteines in their active site. This gene undergoes alternative splicing to produce multiple isoforms, one of which is ubiquitously expressed and localizes to mitochondria, where it functions in mitochondrial redox homeostasis and is important for the protection against and recovery from oxidative stress. Other isoforms, which have more restrictive expression patterns, show cytosolic and nuclear localization, and are thought to function in cellular differentiation and transformation, possibly with a role in tumor progression. [provided by RefSeq, Aug 2011]

GLRX2 Products(3)

mRNA Protein Name
NM_001243399.2 NP_001230328.1 glutaredoxin 2 isoform 3
NM_016066.4 NP_057150.2 glutaredoxin 2 isoform 1
NM_197962.3 NP_932066.1 glutaredoxin 2 isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
11297543 GOA
located in nucleus IDA
IDA: Inferred from direct assay
11297543 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLRX2 Protein Structure

Glutaredoxin

Glutaredoxin: Glutaredoxin (69 - 131)

  • 0
  • 100
  • 164 a.a.
Protein Preferred Names Protein Names

glutaredoxin 2

bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2)

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05497 GLRX2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus GLRX2 VGNC VGNC:29416
Canis familiaris GLRX2 VGNC VGNC:41274
Rattus norvegicus GLRX2 RGD RGD:1307950
Mus musculus GLRX2 MGD MGI:1916617
Macaca mulatta GLRX2 VGNC VGNC:72950