ZDHHC9 - zinc finger DHHC-type palmitoyltransferase 9 Gene

Homo sapiens

Also known as CGI89; DHHC9; MMSA1; MRXSR; MRXSZ; ZNF379; ZNF380; CXorf11; ZDHHC10

Gene ID: 51114 | Gene type: protein coding

About ZDHHC9

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:129,803,288-129,843,886 (from NCBI)

This gene has 5 transcripts (splice variants), 213 orthologues, 17 paralogues and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 17.9), kidney (RPKM 10.5) and 25 other tissues.

Summary

This gene encodes an integral membrane protein that is a member of the zinc finger DHHC domain-containing protein family. The encoded protein forms a complex with golgin subfamily A member 7 and functions as a palmitoyltransferase. This protein specifically palmitoylates HRAS and NRAS. Mutations in this gene are associated with X-linked cognitive disability. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, May 2010]

ZDHHC9 Products(2)

mRNA	Protein	Name
NM_001008222.3	NP_001008223.1	palmitoyltransferase ZDHHC9
NM_016032.4	NP_057116.2	palmitoyltransferase ZDHHC9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Ras palmitoyltransferase activity	IDA IDA: Inferred from direct assay	16000296	GOA
enables palmitoyltransferase activity	IDA IDA: Inferred from direct assay	23034182	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25910212	GOA
enables protein-cysteine S-palmitoyltransferase activity	IDA IDA: Inferred from direct assay	37802025	GOA
enables protein-cysteine S-palmitoyltransferase activity	IMP IMP: Inferred from mutant phenotype	34599882	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in peptidyl-L-cysteine S-palmitoylation	IDA IDA: Inferred from direct assay	16000296	GOA
involved in peptidyl-L-cysteine S-palmitoylation	IMP IMP: Inferred from mutant phenotype	27481942	GOA
involved in positive regulation by host of viral process	IDA IDA: Inferred from direct assay	34599882	GOA
involved in positive regulation by host of viral process	IMP IMP: Inferred from mutant phenotype	34599882	GOA
involved in positive regulation of cGAS/STING signaling pathway	IDA IDA: Inferred from direct assay	37802025	GOA
involved in positive regulation of pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	38530158	GOA
involved in protein palmitoylation	IDA IDA: Inferred from direct assay	23034182	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	16647879	GOA
located in Golgi membrane	IDA IDA: Inferred from direct assay	16000296	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16000296	GOA
part of palmitoyltransferase complex	IDA IDA: Inferred from direct assay	16000296	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC9 Protein Structure

DHHC

0
100
200
300
364 a.a.

Protein Preferred Names

Protein Names

palmitoyltransferase ZDHHC9

Asp-His-His-Cys domain containing protein 9

ZDHHC9 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZDHHC9	Q9Y397	CREB3	Homo sapiens	O43889-2	Validated Y2H	25910212
Intra	ZDHHC9	Q9Y397	CREB3	Homo sapiens	O43889-2	Y2H Array	25910212
Intra	ZDHHC9	Q9Y397	CREB3	Homo sapiens	O43889-2	Y2H Bait-Prey Pool	25910212

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, X-Linked, Syndromic, Raymond Type

MRXSR	Syndromic X-Linked Intellectual Disability Raymond Type
Mental Retardation, X-Linked, Syndromic, Raymond Type	Mental Retardation, X-Linked Syndromic, Raymond Type
Intellectual Developmental Disorder, X-Linked Syndromic, Raymond Type	X-Linked Syndromic Intellectual Developmental Disorder Raymond Type

Intellectual Developmental Disorder, X-Linked, Syndromic, Lujan-Fryns Type

Lujan-Fryns Syndrome	X-Linked Intellectual Disability With Marfanoid Habitus
MRXSLF	Mental Retardation, X-Linked, With Marfanoid Habitus, 1

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome	Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome
Syndactyly With Renal And Anogenital Malformations	STAR
Syndactyly, Telecanthus, Anogenital And Renal Malformations	Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Benign Epilepsy With Centrotemporal Spikes

Rolandic Epilepsy	Benign Rolandic Epilepsy
Epilepsy, Rolandic	Bcects
Benign Childhood Epilepsy With Centrotemporal Spike	Sylvan Seizures
Becrs	Bects
Bre	Benign Epilepsy Of Childhood With Centrotemporal Spikes
Benign Familial Epilepsy Of Childhood With Rolandic Spikes	Centrotemporal Epilepsy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-155938	Cyano-myracrylamide	Inhibitor	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16024	ZDHHC9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ZDHHC9	VGNC	VGNC:37146
Felis catus	ZDHHC9	VGNC	VGNC:67220
Canis familiaris	ZDHHC9	VGNC	VGNC:48595
Mus musculus	ZDHHC9	MGD	MGI:2444393
Macaca mulatta	ZDHHC9	VGNC	VGNC:79147
Rattus norvegicus	ZDHHC9	RGD	RGD:1561389

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