DYNC1LI1 - dynein cytoplasmic 1 light intermediate chain 1 Gene

Homo sapiens

Also known as LIC1; DLC-A; DNCLI1

Gene ID: 51143 | Gene type: protein coding

About DYNC1LI1

Cytogenetic location: 3p22.3 Genomic coordinates (GRCh38): 3:32,525,974-32,570,858 (from NCBI)

This gene has 8 transcripts (splice variants), 225 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 27.3), heart (RPKM 19.1) and 25 other tissues.

Summary

The protein encoded by this gene belongs to light intermediate subunit family, whose members are components of the multiprotein cytoplasmic dynein complex, which is involved in intracellular trafficking and chromosome segregation during mitosis. The protein plays a role in moving the spindle assembly checkpoint (SAC) from kinetochores to spindle poles. The protein may also mediate binding to Other cargo molecules to facilitate intracellular vesicle trafficking. [provided by RefSeq, Jul 2016]

DYNC1LI1 Products(2)

mRNA	Protein	Name
NM_001329135.2	NP_001316064.1	cytoplasmic dynein 1 light intermediate chain 1 isoform 2
NM_016141.4	NP_057225.2	cytoplasmic dynein 1 light intermediate chain 1 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	25272277	GOA
NOT enables GTP binding	IDA IDA: Inferred from direct assay	25272277	GOA
enables dynein heavy chain binding	IPI IPI: Inferred from physical interaction	25272277	GOA
enables molecular adaptor activity	EXP EXP: Inferred from Experiment	30615611	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25272277	GOA
enables protein-macromolecule adaptor activity	IDA IDA: Inferred from direct assay	30615611	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in early endosome to recycling endosome transport	IDA IDA: Inferred from direct assay	20026645	GOA
involved in microtubule-based movement	IDA IDA: Inferred from direct assay	20026645	GOA
involved in microtubule-based movement	IMP IMP: Inferred from mutant phenotype	20026645	GOA
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint	IMP IMP: Inferred from mutant phenotype	19229290	GOA
involved in regulation of vesicle-mediated transport	IDA IDA: Inferred from direct assay	20026645	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
part of cytoplasmic dynein complex	IDA IDA: Inferred from direct assay	19229290	GOA
located in endocytic vesicle membrane	IDA IDA: Inferred from direct assay	20026645	GOA
located in kinetochore	IDA IDA: Inferred from direct assay	19229290	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	19229290	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYNC1LI1 Protein Structure

DLIC

0
100
200
300
400
523 a.a.

Protein Preferred Names

Protein Names

cytoplasmic dynein 1 light intermediate chain 1

dynein light chain A

DYNC1LI1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DYNC1LI1	Q9Y6G9	PGAM2	Homo sapiens	P15259	Y2H Prey Pooling	32296183
Intra	DYNC1LI1	Q9Y6G9	PGAM2	Homo sapiens	P15259	Y2H Array	32296183
Intra	DYNC1LI1	Q9Y6G9	REL	Homo sapiens	Q04864	Validated Y2H	25416956
Intra	DYNC1LI1	Q9Y6G9	REL	Homo sapiens	Q04864	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Myostatin-Related Muscle Hypertrophy

Mslhp

Muscle Hypertrophy Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04085	DYNC1LI1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DYNC1LI1	VGNC	VGNC:61678
Rattus norvegicus	DYNC1LI1	RGD	RGD:71072
Macaca mulatta	DYNC1LI1	VGNC	VGNC:84187
Canis familiaris	DYNC1LI1	VGNC	VGNC:40146
Bos taurus	DYNC1LI1	VGNC	VGNC:28272
Mus musculus	DYNC1LI1	MGD	MGI:2135610

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