REL - REL proto-oncogene, NF-kB subunit Gene

Homo sapiens

Also known as C-Rel; IMD92; HIVEN86A

Gene ID: 5966 | Gene type: protein coding

About REL

Cytogenetic location: 2p16.1 Genomic coordinates (GRCh38): 2:60,881,574-60,931,612 (from NCBI)

This gene has 8 transcripts (splice variants), 208 orthologues, 4 paralogues and is associated with 80 phenotypes. Ubiquitous expression in bone marrow (RPKM 13.2), appendix (RPKM 8.6) and 25 other tissues.

Summary

This gene encodes a protein that belongs to the Rel homology domain/immunoglobulin-like fold, plexin, transcription factor (RHD/IPT) family. Members of this family regulate genes involved in Apoptosis, inflammation, the immune response, and oncogenic processes. This proto-oncogene plays a role in the survival and proliferation of B lymphocytes. Mutation or amplification of this gene is associated with B-cell lymphomas, including Hodgkin's lymphoma. Single nucleotide polymorphisms in this gene are associated with susceptibility to ulcerative colitis and rheumatoid arthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

REL Products(4)

mRNA	Protein	Name
XM_017004627.3	XP_016860116.1	proto-oncogene c-Rel isoform X1
XM_011533010.4	XP_011531312.1	proto-oncogene c-Rel isoform X2
NM_002908.4	NP_002899.1	proto-oncogene c-Rel isoform 1
NM_001291746.2	NP_001278675.1	proto-oncogene c-Rel isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	1406630	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1406630	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10498867	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	22065573	GOA
involved in negative regulation of interferon-beta production	IDA IDA: Inferred from direct assay	22065573	GOA
involved in positive regulation of canonical NF-kappaB signal transduction	IEP IEP: Inferred from expression pattern	12761501	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1406630	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IMP IMP: Inferred from mutant phenotype	22065573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REL Protein Structure

RHD_DNA_bind

0
100
200
300
400
500
619 a.a.

Protein Preferred Names

Protein Names

proto-oncogene c-Rel

oncogene REL, avian reticuloendotheliosis

v-rel avian reticuloendotheliosis viral oncogene homolog

Related Diseases

Diseases

Alias

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Peroxisome Biogenesis Disorder 11a

PBD11A	Peroxisome Biogenesis Disorder Complementation Group 13
PBD-CG13	Cg13
Pbd-Cgh	Peroxisome Biogenesis Disorder Complementation Group H
Peroxisome Biogenesis Disorder, Type 11a	Peroxisome Biogenesis Disorder, Complementation Group 13

Diffuse Large B-Cell Lymphoma

Dlbcl	Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
Large B-Cell Diffuse Lymphoma	Lymphoma, Large B-Cell, Diffuse
Dlbcl - [Diffuse Large B-Cell Lymphoma]	Diffuse Large Beta Cell Lymphoma

T-Cell Acute Lymphoblastic Leukemia

T-Cell Leukemia	Acute T Cell Leukemia
Precursor T Lymphoblastic Leukemia	Precursor T-Lymphoblastic Lymphoma/Leukemia
T Acute Lymphoblastic Leukemia	T-Cell Acute Lymphocytic Leukaemia
T-Cell Lymphoblastic Leukemia/Lymphoma	Leukemia T-Cell
Leukemia, T-Cell	Leukemia, Acute, Lymphoblastic, T-Cell
Leukemia, T-Cell Acute Lymphoblastic	Leukemia, Acute T-Cell
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	Precursor T-Cell Lymphoblastic Lymphoma
Precursor T Cell Lymphoblastic Leukemia/Lymphoblastic Lymphoma

Immunodeficiency 92

IMD92

Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Colitis

Ethmoid Sinus Adenocarcinoma

Adenocarcinoma Of Ethmoid Sinus

Adenocarcinoma Of The Ethmoid Sinus

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Immune Deficiency Disease

Immunodeficiency	Primary Immunodeficiency Disease
Primary Immunodeficiency	Immunologic Deficiency Syndromes
Hypoimmunity	Immune Deficiency Disorder
Immunodeficiency Syndrome	Immune Disorder
Primary Immune Deficiency Disorder	Immune System Diseases
Human Immunodeficiency Virus Infection	Hiv - [Human Immunodeficiency Virus Infection]
Hiv Positive Nos	Hiv Disease
Acquired Immune Deficiency Syndrome-Related Complex	Aids-Like Syndrome
Aids-Related Complex Nos	Arc - [Aids-Related Complex]
Immunodeficiency Due To Human Immunodeficiency Virus Infection	Unspecified Human Immunodeficiency Virus Disease
Hiv Disease Nos	Human Immunodeficiency Virus Positive Nos
Hiv Nos	Deficiency Of Complement Initial Pathway
Deficiency Of Complement Terminal Pathway	Cfdd - [Complement Factor D Deficiency]
Immunodeficiency With Nk-Cell - [Natural-Killer Cell] Deficiency	Nonfamilial Hypogammaglobulinaemia
Common Variable Immune Deficiency	Nonfamilial Agammaglobulinaemia
Common Variable Agammaglobulinaemia	Agammaglobulinaemia Nos
Agammaglobulinaemia Antibody Deficiency Syndrome	Hypogammaglobulinaemia Antibody Deficiency Syndrome
Acquired Agammaglobulinaemia Nos	Hypogammaglobulinaemia Nos
Hyper Igm

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Alzheimer Disease 7

Ad7	Alzheimer'S Disease 7
Alzheimer Disease, Familial, 7	Alzheimer Disease-7
Alzheimer Disease, Familial 7

Follicular Lymphoma

Lymphoma, Follicular	Lymphoma Follicular
Brill-Symmers' Disease	Large Cell Follicular Non-Hodgkin Lymphoma
Diffuse Follicle Centre Lymphoma	Diffuse Follicular Lymphoma Nos
Follicular Nodular Non-Hodgkin Lymphoma, Unspecified	Follicular Large Cell Cleaved Or Noncleaved Lymphoma
Large Cell Follicular Noncleaved Lymphoma	Follicular Lymphoma With Or Without Diffuse Areas
Histiocytic Follicular Lymphoma	Histiocytic Nodular Lymphoma
Histiocytic Nodular Malignant Lymphoma	Large Cell Follicular Lymphoma
Large Cell Noncleaved Follicular Lymphoma	Large Cell Noncleaved Follicular Malignant Lymphoma
Nodular Reticulum Cell Sarcoma	Noncleaved Follicular Lymphoma

Hypersplenism

Hypersplenia	Big Spleen Syndrome
Hyperfunction Of Spleen	Increased Splenic Activity
Spleen Metaplasia	Splenic Metaplasia

Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum	Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis
Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Internal Hordeolum

Endometrial Cancer

Endometrial Carcinoma	Endometrial Neoplasm
Malignant Neoplasm Of Endometrium	Endometrioid Carcinoma
Endometrial Neoplasms	Carcinoma, Endometrioid
Endometrial Cancer, Familial	Endometrial Carcinoma, Somatic
Endometrial Cancer, Susceptibility To	Endometrial Ca
Malignant Endometrial Neoplasm	Neoplasm Of Endometrium
Primary Malignant Neoplasm Of Endometrium	Tumor Of Endometrium
Carcinoma Of The Endometrium	Endometrioid Carcinoma Of Female Reproductive System
ENDMC	Carcinoma Endometrioid
Endometrial Cancers	Cancer, Endometrial
Uterine Corpus Cancer

Reticuloendotheliosis, X-Linked

Reticuloendotheliosis

Rheumatoid Arthritis

RA	Arthritis, Rheumatoid
Rheumatoid Arthritis, Susceptibility To	Arthritis Or Polyarthritis, Rheumatic
Atrophic Arthritis	Rheumatism Arthritis
Rheumatoid Polyarthritis

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Renal Pelvis Transitional Cell Carcinoma

Urothelial Cell Carcinoma Of Renal Pelvis	Renal Pelvis Urothelial Carcinoma
Transitional Cell Carcinoma Of Renal Pelvis

Pancreatic Cancer

Pancreatic Carcinoma	Familial Pancreatic Carcinoma
Pancreatic Neoplasm	Carcinoma Of Pancreas
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Pancreatic Carcinoma, Somatic	Pancreatic Cancer, Somatic
Ca Body Of Pancreas	Ca Head Of Pancreas
Ca Tail Of Pancreas	Malignant Neoplasm Of Body Of Pancreas
Malignant Neoplasm Of Head Of Pancreas	Malignant Neoplasm Of Tail Of Pancreas
Pancreas Neoplasm	Exocrine Cancer
Exocrine Pancreas Carcinoma	Hereditary Pancreatic Cancer
Hereditary Pancreatic Carcinoma	PNCA
Cancer Of The Pancreas	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

B-Cell Lymphoma

Lymphoma, B-Cell	B-Cell Lymphomas
B-Cell Lymphocytic Neoplasm	Lymphoma B-Cell
B-Cell Lymphoma Nos

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency	Congenital Combined Immunodeficiency
Syndrome With Combined Immunodeficiency	Combined T And B Cell Immunodeficiency
Combined Immunity Deficiency	Combined Immunodeficiency Syndrome
Combined T-Cell And B-Cell Immunodeficiency	Lymphopenic Agammaglobulinaemia

Inhibited Male Orgasm

Male Orgasmic Disorder

Psychosexual Dysfunction With Male Orgasmic Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-17371A	(rel)-Oxaliplatin		/	Unkown

Clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Phase
HY-122359A	rel-Levormeloxifene	/	Phase 3
HY-117283	rel-Aprikalim	/	Phase 2
HY-135238	(rel)-RSD 921	/	Phase 2

Pre-clinical Phase

Bioactive Molecules (78)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15917	DL-dithiothreitol	Inhibitor	99.43%	Unkown
HY-12276	MALT1 inhibitor MI-2	Inhibitor	99.95%	Unkown
HY-139426A	(rel)-ML-SI3		99.81%	Unkown
HY-119940	MC180295	Inhibitor	98.89%	Unkown
HY-124179	IT-901	Inhibitor	≥99.0%	Unkown
HY-120006A	(rel)-AR234960	Agonist	99.42%	Unkown
HY-121508	(E/Z)-IT-603	Inhibitor	99.91%	Unkown
HY-B0757A	(±)-α-Tocopherol nicotinate		99.80%	Unkown
HY-B1890	(±)-Catechin	Inhibitor	98.38%	Unkown
HY-160440	rel-VU6021625		99.67%	Unkown
HY-160477	DC-SX029	Inhibitor	98.07%	Unkown
HY-N0683A	rel-α-Vitamin E		≥70.0%	Unkown
HY-112163A	rel-Zotatifin		97.32%	Unkown
HY-113068	(rel)-β-Tocopherol	Inhibitor	≥99.0%	Unkown
HY-114324A	rel-PROTAC PARP1 degrader	Degrader	98.99%	Unkown
HY-128838A	(rel)-PROTAC ERRα Degrader-1		95.89%	Unkown
HY-18941B	(rel)-Eglumegad	Agonist	≥97.0%	Unkown
HY-77493	(rel)-Tivantinib		96.45%	Unkown
HY-N2207	rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan		99.95%	Unkown
HY-101387	rel-ACPT-I	Agonist	≥99.0%	Unkown
HY-111537	rel-AZ5576		/	Unkown
HY-106874B	rel-Delequamine		/	Unkown
HY-110020	rel-O-2050	Antagonist	/	Unkown
HY-113239S1	rel-Hydroxycotinine-d3		/	Unkown
HY-122495	rel-Quinpirole dihydrochloride	Agonist	/	Unkown
HY-12422C	rel-(2S,3R)-Voruciclib	Inhibitor	/	Unkown
HY-12422E	rel-(2S,3R)-Voruciclib hydrochloride		/	Unkown
HY-124874	(rel)-Asperparaline A	Antagonist	/	Unkown
HY-12650A	(rel)-Mirogabalin	Inhibitor	/	Unkown
HY-13204S1	rel-Biperiden-d5	Inhibitor	/	Unkown
HY-13204S2	rel-Biperiden EP impurity A-d5	Inhibitor	/	Unkown
HY-13204S3	rel-Biperiden EP impurity B-d5	Inhibitor	/	Unkown
HY-13607A	(rel)-BMS-641988	Antagonist	/	Unkown
HY-140902	rel-Biotin-PEG3-C3-NH2		/	Unkown
HY-143785S	rel-Saxagliptin-15N,d2 hydrochloride		/	Unkown
HY-144681A	rel-LY3372689	Inhibitor	/	Unkown
HY-14588S	(rel)-Lopinavir-d8		/	Unkown
HY-151216S	rel-Paroxetine-d4 hydrochloride		/	Unkown
HY-15793A	Trans (2,3)-Dihydrotetrabenazine	Inhibitor	/	Unkown
HY-17423S1	rel-Abacavir-d4		/	Unkown
HY-17447SA	Tranylcypromine-d5 hydrochloride	Inhibitor	/	Unkown
HY-18295A	rel-Erteberel	Agonist	/	Unkown
HY-18617	rel-SB-612111 hydrochloride	Inhibitor	/	Unkown
HY-65039A	rel-Boc-Hyp-OMe		/	Unkown
HY-78746A	(3S,4R,5S)-rel-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxylic acid		96.90%	Unkown
HY-90001S3	rel-Ritonavir-d6		≥98.0%	Unkown
HY-B0141S7	rel-Estradiol-13C6		/	Unkown
HY-B0176AS	rel-Sertraline-d3 hydrochloride	Inhibitor	/	Unkown
HY-B0511S1	rel-Biotin-d4		98.04%	Unkown
HY-N10837	rel-3R-Methoxy-4S-furanogermacra-1E,10(15)-dien-6-one		/	Unkown
HY-RS06707	IL17REL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11823	REL Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11824	Rel Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS11825	Rel Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W015597S	rel-3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione-d6		/	Unkown
HY-W415923	rel-6-Deoxy-6-fluoroglucopyranose		/	Unkown
HY-W588220	rel-cis-Pinic acid		/	Unkown
HY-W756041	rel-(1S,2S)-Dihydro bupropion-d9 hydrochloride		/	Unkown
HY-100243A	Norcisapride		/	Unkown
HY-10285S1	(rel)-Saxagliptin-13C,d2 TFA	Inhibitor	/	Unkown
HY-106899A	(rel)-MK 287		/	Unkown
HY-128732	rel-(2R,3S)-2,3-Dihydroxysuccinic acid hydrate		/	Unkown
HY-13047A	rel-S-(+)-Mecamylamine hydrochloride		/	Unkown
HY-134180	rel-Carbovir monophosphate		/	Unkown
HY-14645B	DHMEQ racemate	Inhibitor	/	Unkown
HY-14690B	rel-Ecopipam hydrobromide	Antagonist	/	Unkown
HY-157571S	N-6-[rel-(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinamine-Sonidegib-d8		/	Unkown
HY-157856	rel-4(5)-Epdpe methyl ester		/	Unkown
HY-165976	rel-(9R,10R)-9,10-Dihydroxyhexadecanoic acid		/	Unkown
HY-166057	trans-15,16-Epoxy-octadecanoic acid		/	Unkown
HY-166062	trans-5,6-Epoxy-9(Z),12(Z)-octadecadienoic acid		/	Unkown
HY-166238	rel-Linoleic acid-biotin		/	Unkown
HY-18957A	rel-Lifirafenib		/	Unkown
HY-19153	Nepaprazole	Inhibitor	/	Unkown
HY-B0492S	rel-Paroxetine-d4-1 hydrochloride		/	Unkown
HY-W710914A	rel-HDMP 28 hydrochloride		/	Unkown
HY-W745349	rel-(1S,2R)-Dihydro bupropion-d9 hydrochloride		/	Unkown
HY-W777138	rel-(1S,2R)-Dihydro bupropion-d9		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	REL	VGNC	VGNC:76892
Mus musculus	REL	MGD	MGI:97897
Felis catus	REL	VGNC	VGNC:69282
Canis familiaris	REL	VGNC	VGNC:45465
Bos taurus	REL	VGNC	VGNC:33857
Rattus norvegicus	REL	RGD	RGD:1311231
Macaca fascicularis	REL	NCBI	NCBI:102116653
Canis lupus familiaris	REL	NCBI
Others	REL	NCBI