HAO2 - hydroxyacid oxidase 2 Gene

Homo sapiens

Also known as GIG16; HAOX2

Gene ID: 51179 | Gene type: protein coding

About HAO2

Cytogenetic location: 1p12 Genomic coordinates (GRCh38): 1:119,368,785-119,394,130 (from NCBI)

This gene has 5 transcripts (splice variants), 198 orthologues and 2 paralogues. Biased expression in kidney (RPKM 63.1) and liver (RPKM 51.5).

Summary

This gene is one of three related genes that have 2-hydroxyacid oxidase activity. The encoded protein localizes to the peroxisome has the highest activity toward the substrate 2-hydroxypalmitate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

HAO2 Products(3)

mRNA	Protein	Name
NM_001005783.3	NP_001005783.2	2-Hydroxyacid oxidase 2 isoform 2
NM_001377472.1	NP_001364401.1	2-Hydroxyacid oxidase 2 isoform 3
NM_016527.4	NP_057611.1	2-Hydroxyacid oxidase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables (S)-2-hydroxy-acid oxidase activity	IDA IDA: Inferred from direct assay	10777549	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid oxidation	IDA IDA: Inferred from direct assay	10777549	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in peroxisomal matrix	IDA IDA: Inferred from direct assay	10777549	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HAO2 Protein Structure

FMN_dh

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

2-Hydroxyacid oxidase 2

(S)-2-hydroxy-acid oxidase, peroxisomal

HAO2 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HAO2	Q9NYQ3	SEC14L4	Homo sapiens	Q9UDX3	Validated Y2H	32296183
Intra	HAO2	Q9NYQ3	SEC14L4	Homo sapiens	Q9UDX3	Y2H Array	32296183
Intra	HAO2	Q9NYQ3	SEC14L4	Homo sapiens	Q9UDX3	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Histidinemia

Histidine Ammonia-Lyase Deficiency	Hal Deficiency
Histidase Deficiency	His Deficiency
Histidinuria	Hyperhistidinemia
HISTID	Histidinuria Renal Tubular Defect

Histidine Metabolism Disease

Disturbances Of Histidine Metabolism	Disorder Of Histidine Metabolism
Disturbance Of Histidine Metabolism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS05999	HAO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HAO2	VGNC	VGNC:81416
Canis familiaris	HAO2	VGNC	VGNC:41591
Rattus norvegicus	HAO2	RGD	RGD:70972
Bos taurus	HAO2	VGNC	VGNC:29748
Mus musculus	HAO2	MGD	MGI:96012
Felis catus	HAO2	VGNC	VGNC:80227

Name
Email *

	Sorry, but the email address you supplied was invalid.