2. Gene
  3. SS18L2 - SS18 like 2 Gene

SS18L2 - SS18 like 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as KIAA-iso

Gene ID: 51188 | Gene type: protein coding

About SS18L2

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:42,581,840-42,596,934 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues and 2 paralogues. Ubiquitous expression in lymph node (RPKM 8.2), prostate (RPKM 6.4) and 25 other tissues.

Summary

Synovial sarcomas occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the SS18 gene (MIM 600192) is fused in-frame to the 3-prime end of the SSX1 (MIM 312820), SSX2 (MIM 300192), or SSX4 (MIM 300326) gene. The SS18L2 gene is homologous to SS18.[supplied by OMIM, Jul 2002]

SS18L2 Products(2)

mRNA Protein Name
NM_001370300.1 NP_001357229.1 SS18-like protein 2
NM_016305.4 NP_057389.1 SS18-like protein 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SS18L2 Protein Structure

SSXT

SSXT: SSXT protein (N-terminal region) (11 - 75)

  • 0
  • 77 a.a.
Protein Preferred Names Protein Names

SS18-like protein 2

SYT homolog 2

SS18L2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SS18L2 Q9UHA2 GNG3 Homo sapiens P63215
Y2H Prey Pooling
32296183
Intra
SS18L2 Q9UHA2 GNG3 Homo sapiens P63215
Y2H Array
32296183
Intra
SS18L2 Q9UHA2 TMEM17 Homo sapiens Q86X19
Y2H Prey Pooling
32296183
Intra
SS18L2 Q9UHA2 TMEM17 Homo sapiens Q86X19
Y2H Array
32296183
Intra
SS18L2 Q9UHA2 LYPD6 Homo sapiens Q86Y78
Y2H Array
32296183
Intra
SS18L2 Q9UHA2 LYPD6 Homo sapiens Q86Y78
Y2H Prey Pooling
32296183
Intra
SS18L2 Q9UHA2 MBD5 Homo sapiens Q9P267-2
Y2H Prey Pooling
32296183
Intra
SS18L2 Q9UHA2 MBD5 Homo sapiens Q9P267-2
Y2H Array
32296183
Intra
SS18L2 Q9UHA2 EMC2 Homo sapiens Q15006
Y2H Prey Pooling
32296183
Intra
SS18L2 Q9UHA2 EMC2 Homo sapiens Q15006
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13803 SS18L2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SS18L2 VGNC VGNC:46825
Rattus norvegicus SS18L2 RGD RGD:1590139
Felis catus SS18L2 VGNC VGNC:102850
Mus musculus SS18L2 MGD MGI:1349474