2. Gene
  3. VRK3 - VRK serine/threonine kinase 3 Gene

VRK3 - VRK serine/threonine kinase 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 51231 | Gene type: protein coding

About VRK3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,976,468-50,025,372 (from NCBI)

This gene has 26 transcripts (splice variants), 278 orthologues and 12 paralogues. Broad expression in testis (RPKM 36.5), small intestine (RPKM 9.1) and 24 other tissues.

Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. In both human and mouse, this gene has substitutions at several residues within the ATP binding motifs that in Other kinases have been shown to be required for catalysis. In vitro assays indicate the protein lacks phosphorylation activity. The protein, however, likely retains its substrate binding capability. This gene is widely expressed in human tissues and its protein localizes to the nucleus. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

VRK3 Products(3)

mRNA Protein Name
NM_001025778.2 NP_001020949.1 inactive serine/threonine-protein kinase VRK3 isoform 2
NM_001308420.3 NP_001295349.1 inactive serine/threonine-protein kinase VRK3 isoform 3
NM_016440.4 NP_057524.3 inactive serine/threonine-protein kinase VRK3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25609649 GOA
enables protein phosphatase binding IDA
IDA: Inferred from direct assay
22572157 GOA
Biological Process GO Annotation Evidence Reference Source
involved in skeletal muscle tissue development IGI
IGI: Inferred from genetic interaction
35140224 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VRK3 Protein Structure

zf-ribbon_3

zf-ribbon_3: zinc-ribbon domain (4 - 26)

Pkinase

Pkinase: Protein kinase domain (252 - 437)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 474 a.a.
Protein Preferred Names Protein Names

inactive serine/threonine-protein kinase VRK3

serine/threonine-protein kinase VRK3

VRK3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
VRK3 Q8IV63 MAX Homo sapiens P61244
Pull Down
25609649
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Vaccinia
Microcephaly, Seizures, And Developmental Delay

MCSZ

Developmental And Epileptic Encephalopathy 10

Epileptic Encephalopathy, Early Infantile, 10

Eiee10

Dee10

Early Infantile Epileptic Encephalopathy 10
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15704 VRK3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris VRK3 VGNC VGNC:48304
Rattus norvegicus VRK3 RGD RGD:1549692
Felis catus VRK3 VGNC VGNC:97684
Mus musculus VRK3 MGD MGI:2182465
Macaca mulatta VRK3 VGNC VGNC:81605
Bos taurus VRK3 VGNC VGNC:36836
Others VRK3 NCBI