CLEC1B - C-type lectin domain family 1 member B Gene

Homo sapiens

Also known as CLEC2; CLEC2B; PRO1384; QDED721; 1810061I13Rik

Gene ID: 51266 | Gene type: protein coding

About CLEC1B

Cytogenetic location: 12p13.31-p13.2 Genomic coordinates (GRCh38): 12:9,993,075-10,001,899 (from NCBI)

This gene has 4 transcripts (splice variants), 365 orthologues and 23 paralogues. Biased expression in liver (RPKM 4.2), bone marrow (RPKM 0.6) and 1 other tissue.

Summary

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells (Colonna et al., 2000 [PubMed 10671229]).[supplied by OMIM, Jan 2011]

CLEC1B Products(3)

mRNA	Protein	Name
NM_001099431.2	NP_001092901.1	C-type lectin domain family 1 member B isoform b
NM_001393342.1	NP_001380271.1	C-type lectin domain family 1 member B isoform a
NM_016509.4	NP_057593.3	C-type lectin domain family 1 member B isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17616532	GOA
enables transmembrane signaling receptor activity	IDA IDA: Inferred from direct assay	18955485	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in signal transduction	IDA IDA: Inferred from direct assay	18955485	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLEC1B Protein Structure

Lectin_C

0
100
200
229 a.a.

Protein Preferred Names

Protein Names

C-type lectin domain family 1 member B

C-type lectin-like receptor 2

Recombinant CLEC1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75336	CLEC1B/CLEC-2 Protein, Human (HEK293, His)	Q9P126 (Q58-P229)	≥95%

Related Diseases

Diseases

Alias

Bleeding Disorder, Platelet-Type, 11

BDPLT11	Glycoprotein Vi Deficiency
Gp Vi Deficiency	Platelet-Type Bleeding Disorder 11
Bleeding Diathesis Due To A Collagen Receptor Defect	Bleeding Diathesis Due To Glycoprotein Vi Deficiency
Platelet-Type Bleeding Disorder-11	Bleeding Disorder, Platelet Type 11
Hemorrhage

Human Immunodeficiency Virus Type 1

Aids	Hiv/Aids
Aids, Delayed/Rapid Progression To	Hiv-1, Susceptibility To
Hiv-1 Viremia, Susceptibility To	Human Immunodeficiency Virus Type 1, Susceptibility To
Hiv-1	Aids, Slow Progression To
Rapid Progression To Aids From Hiv1 Infection	Hiv1 Infection, Resistance To
Hiv1 Infection	Hiv-1 Viremia
Aids, Resistance To	Aids, Rapid Progression To
Hiv/Aids, Susceptibility To	Hiv-1, Resistance To
Hiv1, Resistance To	Hiv1
Hiv-1 Disease, Delayed Progression Of	Hiv-1 Disease, Rapid Progression Of
Hiv Infection, Resistance To	Hiv Type 1, Susceptibility To
Hiv Type 1	Hiv-1 Infection
Human Immunodeficiency Virus I Infection	Acquired Immunodeficiency Syndrome
Hiv-Infection/Aids

Bladder Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Bladder	Epidermoid Carcinoma Of The Urinary Bladder
Carcinoma Squamous Cell Bladder

Blood Platelet Disease

Platelet Disorder	Blood Platelet Disorders
Thrombocytopathy	Platelet Dysfunction
Platelet Disorders	Qualitative Platelet Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02786	CLEC1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CLEC1B	RGD	RGD:1563517
Felis catus	CLEC1B	VGNC	VGNC:60946
Bos taurus	CLEC1B	VGNC	VGNC:58366
Canis familiaris	CLEC1B	VGNC	VGNC:49802
Macaca mulatta	CLEC1B	VGNC	VGNC:71336
Mus musculus	CLEC1B	MGD	MGI:1913287
Others	CLEC1B	NCBI

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