CLEC1B/CLEC-2 Protein, Human (HEK293, His)

CLEC1B/CLEC-2 protein is a C-type lectin-like receptor that acts as a platelet receptor and snake venom protein receptor for PDPN in microbial infections. Upon activation, it initiates a signaling cascade involving SRC and SYK kinases, leading to PLCG2 activation. CLEC1B/CLEC-2 Protein, Human (HEK293, His) is the recombinant human-derived CLEC1B/CLEC-2 protein, expressed by HEK293 , with N-His labeled tag. The total length of CLEC1B/CLEC-2 Protein, Human (HEK293, His) is 172 a.a., with molecular weight of 35-38 kDa.

CLEC1B/CLEC-2 protein serves as a C-type lectin-like receptor with a notable function as a platelet receptor for the lymphatic endothelial marker, PDPN. Upon ligand activation, it initiates signaling cascades involving the sequential activation of SRC and SYK tyrosine kinases, ultimately leading to the activation of PLCG2. In the context of microbial infection, CLEC1B/CLEC-2 acts as a receptor for the platelet-aggregating snake venom protein rhodocytin. Rhodocytin binding induces tyrosine phosphorylation, facilitating the binding of spleen tyrosine kinase (SYK) and initiating downstream tyrosine phosphorylation events, along with the activation of PLCG2. This multifaceted role highlights the involvement of CLEC1B/CLEC-2 in platelet function and immune responses, particularly in the context of interactions with PDPN and rhodocytin.

Measured by its binding ability in a functional ELISA.

Human

HEK293

N-His

Q9P126 (Q58-P229)

51266  [NCBI]

QRNYLQGENENRTGTLQQLAKRFCQYVVKQSELKGTFKGHKCSPCDTNWRYYGDSCYGFFRHNLTWEESKQYCTDMNATLLKIDNRNIVEYIKARTHLIRWVGLSRQKSNEVWKWEDGSVISENMFEFLEDGKGNMNCAYFHNGKMHPTFCENKHYLMCERKAGMTKVDQLP

35-38 kDa

Greater than 80% as determined by reducing SDS-PAGE.

Solution

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

<1 EU/μg, determined by LAL method.

N/A.

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping with dry ice.