GMPR2 - guanosine monophosphate reductase 2 Gene

Homo sapiens

Also known as GMPR 2

Gene ID: 51292 | Gene type: protein coding

About GMPR2

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,232,622-24,239,242 (from NCBI)

This gene has 29 transcripts (splice variants), 1 gene allele, 187 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 24.5), kidney (RPKM 21.7) and 25 other tissues.

Summary

This gene encodes an Enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular Bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

GMPR2 Products(12)

mRNA	Protein	Name
NM_001002000.3	NP_001002000.1	GMP reductase 2 isoform 2
NM_001002001.3	NP_001002001.1	GMP reductase 2 isoform 2
NM_001002002.3	NP_001002002.1	GMP reductase 2 isoform 2
NM_001283021.2	NP_001269950.1	GMP reductase 2 isoform 3
NM_001283022.2	NP_001269951.1	GMP reductase 2 isoform 4
NM_001283023.2	NP_001269952.1	GMP reductase 2 isoform 5
NM_001351022.2	NP_001337951.1	GMP reductase 2 isoform 6
NM_001351023.2	NP_001337952.1	GMP reductase 2 isoform 6
NM_001351024.2	NP_001337953.1	GMP reductase 2 isoform 7
NM_001351025.2	NP_001337954.1	GMP reductase 2 isoform 7
NM_001351026.2	NP_001337955.1	GMP reductase 2 isoform 7
NM_016576.5	NP_057660.2	GMP reductase 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables GMP reductase activity	IDA IDA: Inferred from direct assay	12669231	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in GMP metabolic process	IDA IDA: Inferred from direct assay	22037469	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GMPR2 Protein Structure

IMPDH

0
100
200
300
348 a.a.

Protein Preferred Names

Protein Names

GMP reductase 2

guanosine 5'-monophosphate oxidoreductase 2

GMPR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GMPR2	Q9P2T1	GMPR	Homo sapiens	P36959	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Urethra Cancer

Cancer Of Urethra	Malignant Tumour Of Urethra
Malignant Urethral Neoplasm	Urethral Ca

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05527	GMPR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GMPR2	VGNC	VGNC:41295
Mus musculus	GMPR2	MGD	MGI:1917903
Macaca mulatta	GMPR2	VGNC	VGNC:73083
Felis catus	GMPR2	VGNC	VGNC:62613
Rattus norvegicus	GMPR2	RGD	RGD:628875

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