FKBP11 - FKBP prolyl isomerase 11 Gene

Homo sapiens

Also known as FKBP19

Gene ID: 51303 | Gene type: protein coding

About FKBP11

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:48,921,963-48,939,034 (from NCBI)

This gene has 13 transcripts (splice variants), 199 orthologues and 18 paralogues. Ubiquitous expression in pancreas (RPKM 27.0), appendix (RPKM 17.8) and 24 other tissues.

Summary

FKBP11 belongs to the FKBP family of peptidyl-prolyl cis/trans isomerases, which catalyze the folding of proline-containing polypeptides. The peptidyl-prolyl isomerase activity of FKBP proteins is inhibited by the immunosuppressant compounds FK506 and rapamycin (Rulten et al., 2006 [PubMed 16596453]).[supplied by OMIM, Mar 2008]

FKBP11 Products(3)

mRNA	Protein	Name
NM_001143781.2	NP_001137253.1	peptidyl-prolyl cis-trans isomerase FKBP11 isoform 2
NM_001143782.2	NP_001137254.1	peptidyl-prolyl cis-trans isomerase FKBP11 isoform 3 precursor
NM_016594.3	NP_057678.1	peptidyl-prolyl cis-trans isomerase FKBP11 isoform 1 precursor

FKBP11 Protein Structure

FKBP_C

0
100
201 a.a.

Protein Preferred Names

Protein Names

peptidyl-prolyl cis-trans isomerase FKBP11

19 kDa FK506-binding protein

Recombinant FKBP11 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76344	FKBP11 Protein, Human (HEK293, Fc)	Q9NYL4 (G28-G155)	≥95%

Related Diseases

Diseases

Alias

Osteogenesis Imperfecta, Type V

Osteogenesis Imperfecta Type 5	OI5
Osteogenesis Imperfecta Type V	Oi Type 5
Oi Type V	Oi, Type V
Oi With Calcification In Interosseous Membranes	Type V Oi
Osteogenesis Imperfecta 5	Oi-V

Caffey Disease

Infantile Cortical Hyperostosis	CAFYD
Cortical Congenital Hyperostosis	Caffey-Silverman Syndrome
De Toni-Caffey Disease	Hyperostosis Cortical Infantile
Hyperostosis, Cortical, Congenital

Brittle Bone Disorder

Osteogenesis Imperfecta	Brittle Bone Disease
Fragilitas Ossium	Osteopsathyrosis
Lobstein Disease	Oi
Vrolik Disease	Lobstein'S Disease
Lobstein'S Syndrome	Vrolik'S Disease
Porak And Durante Disease	Glass Bone Disease
Osteogenesis Imperfecta, Dominant Perinatal Lethal	Osteogenesis Imperfecta, Recessive Perinatal Lethal
Brittle Bone Syndrome	Oi - [Osteogenesis Imperfecta]
Ossium Fragility	Osteitis Fragilitans
Bony Fragility	Blue Sclera With Fragility Of Bone And Deafness
White Blue Sclera - Fragility Of Bone - Deafness

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04957	FKBP11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	FKBP11	RGD	RGD:1306161
Canis familiaris	FKBP11	VGNC	VGNC:40887
Felis catus	FKBP11	VGNC	VGNC:84020
Bos taurus	FKBP11	VGNC	VGNC:29018
Mus musculus	FKBP11	MGD	MGI:1913370
Others	FKBP11	NCBI

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