2. Gene
  3. TNFRSF12A - TNF receptor superfamily member 12A Gene

TNFRSF12A - TNF receptor superfamily member 12A Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as FN14; CD266; TWEAKR

Gene ID: 51330 | Gene type: protein coding

About TNFRSF12A

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,020,368-3,022,383 (from NCBI)

This gene has 7 transcripts (splice variants) and 88 orthologues. Ubiquitous expression in gall bladder (RPKM 21.3), liver (RPKM 18.8) and 23 other tissues.

Summary

Involved in positive regulation of extrinsic apoptotic signaling pathway and regulation of wound healing. Predicted to be located in cell surface and ruffle. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

TNFRSF12A Products(1)

mRNA Protein Name
NM_016639.3 NP_057723.1 tumor necrosis factor receptor superfamily member 12A precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11728344 GOA
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of apoptotic process IDA
IDA: Inferred from direct assay
21525013 GOA
involved in positive regulation of extrinsic apoptotic signaling pathway IMP
IMP: Inferred from mutant phenotype
21525013 GOA
involved in regulation of wound healing IDA
IDA: Inferred from direct assay
11728344 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFRSF12A Protein Structure

stn_TNFRSF12A

stn_TNFRSF12A: Tumour necrosis factor receptor stn_TNFRSF12A_TNFR domain (1 - 129)

  • 0
  • 100
  • 129 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor receptor superfamily member 12A

FGF-inducible 14

TNFRSF12A Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TNFRSF12A Q9NP84 TRAF2 Homo sapiens Q12933
Anti Bait CoIP
21525013
Intra
TNFRSF12A Q9NP84 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Array
32296183
Intra
TNFRSF12A Q9NP84 KRTAP3-3 Homo sapiens Q9BYR6
Y2H Prey Pooling
32296183
Intra
TNFRSF12A Q9NP84 BIRC2 Homo sapiens Q13490
Anti Bait CoIP
21525013
Intra
TNFRSF12A Q9NP84 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
31515488
Intra
TNFRSF12A Q9NP84 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
25416956
Intra
TNFRSF12A Q9NP84 SLC30A2 Homo sapiens Q9BRI3
Y2H Array
32296183
Intra
TNFRSF12A Q9NP84 SLC30A2 Homo sapiens Q9BRI3
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TNFRSF12A Proteins

Cat. No. Product Name Accession Purity
HY-P72434 TNFRSF12A Protein, Human (HEK293, Fc) Q9NP84-1 (E28-W79) ≥95%

TNFRSF12A Antibodies

Cat. No. Product Name Application Reactivity
HY-P82931 CD266 Antibody (YA2676) WB, IHC-P, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99361 Enavatuzumab Inhibitor ≥95.0% Phase 1
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14803 TNFRSF12A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TNFRSF12A VGNC VGNC:47656
Bos taurus TNFRSF12A VGNC VGNC:36162
Mus musculus TNFRSF12A MGD MGI:1351484
Macaca mulatta TNFRSF12A VGNC VGNC:99623
Rattus norvegicus TNFRSF12A RGD RGD:631329
Felis catus TNFRSF12A VGNC VGNC:107825
Others TNFRSF12A NCBI