CDC40 - cell division cycle 40 Gene

Homo sapiens

Also known as EHB3; PCH15; PRP17; PRPF17

Gene ID: 51362 | Gene type: protein coding

About CDC40

Cytogenetic location: 6q21 Genomic coordinates (GRCh38): 6:110,180,427-110,232,232 (from NCBI)

This gene has 7 transcripts (splice variants), 222 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in bone marrow (RPKM 12.9), lymph node (RPKM 10.6) and 25 other tissues.

Summary

Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is found to be essential for the catalytic step II in pre-mRNA splicing process. It is found in the spliceosome, and contains seven WD repeats, which function in protein-protein interactions. This protein has a sequence similarity to yeast Prp17 protein, which functions in two different cellular processes: pre-mRNA splicing and cell cycle progression. It suggests that this protein may play a role in cell cycle progression. [provided by RefSeq, Jul 2008]

CDC40 Products(1)

mRNA	Protein	Name
NM_015891.3	NP_056975.1	pre-mRNA-processing factor 17

CDC40 Protein Structure

WD40

0
100
200
300
400
500
579 a.a.

Protein Preferred Names

Protein Names

pre-mRNA-processing factor 17

EH-binding protein 3

Related Diseases

Diseases

Alias

Pontocerebellar Hypoplasia, Type 15

PCH15	Pontocerebellar Hypoplasia Type 15
Pontocerebellar Hypoplasia 15	Doid:0112326

Pontocerebellar Hypoplasia

Pch	Congenital Pontocerebellar Hypoplasia
Opch	Hypoplasia, Pontocerebellar
Pontoneocerebellar Hypoplasia	Nonsyndromic Pontocerebellar Hypoplasia

Spastic Quadriplegia

Spastic Quadriplegic Cerebral Palsy	Quadriplegic Infantile Cerebral Palsy
Tetraplegic Infantile Cerebral Palsy	Cerebral Palsy Spastic Quadriplegic
Quadriplegic Cerebral Palsy	Spastic Quadriplegia Cerebral Palsy
Spastic Tetraplegia Cerebral Palsy	Cerebral Palsy, Quadriplegic, Infantile
Cerebral Palsy With Spastic Tetraplegia	Congenital Spastic Quadriplegia
Spastic Tetraplegic Cerebral Palsy	Congenital Quadriplegia Nos
Tetraplegic Cerebral Palsy

Quadriplegia

Tetraplegia

Tetraplegias

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02299	CDC40 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDC40	MGD	MGI:1918963
Rattus norvegicus	CDC40	RGD	RGD:1307063
Bos taurus	CDC40	VGNC	VGNC:27068
Macaca mulatta	CDC40	VGNC	VGNC:70798
Canis familiaris	CDC40	VGNC	VGNC:38996
Felis catus	CDC40	VGNC	VGNC:60656

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