ATRAID - all-trans retinoic acid induced differentiation factor Gene

Homo sapiens

Also known as p18; APR3; APR-3; APR--3; PRO240; C2orf28; HSPC013

Gene ID: 51374 | Gene type: protein coding

About ATRAID

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,212,041-27,217,183 (from NCBI)

This gene has 6 transcripts (splice variants) and 188 orthologues. Ubiquitous expression in thyroid (RPKM 48.2), testis (RPKM 45.1) and 25 other tissues.

Summary

This gene is thought to be involved in Apoptosis, and may also be involved in hematopoietic development and differentiation. The use of alternative splice sites and promotors result in multiple transcript variants encoding different isoforms.[provided by RefSeq, Dec 2009]

ATRAID Products(2)

mRNA	Protein	Name
NM_001170795.4	NP_001164266.1	all-trans retinoic acid-induced differentiation factor isoform c precursor
NM_016085.5	NP_057169.2	all-trans retinoic acid-induced differentiation factor isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18388313	GOA
enables xenobiotic transmembrane transporter activity	IDA IDA: Inferred from direct assay	29745899	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of osteoblast proliferation	IDA IDA: Inferred from direct assay	21723284	GOA
involved in negative regulation of protein catabolic process	IDA IDA: Inferred from direct assay	21723284	GOA
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	21723284	GOA
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	21723284	GOA
involved in regulation of gene expression	IDA IDA: Inferred from direct assay	21723284	GOA
involved in xenobiotic transmembrane transport	IDA IDA: Inferred from direct assay	29745899	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in lysosomal membrane	IDA IDA: Inferred from direct assay	29745899	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	21723284	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21723284	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

all-trans retinoic acid-induced differentiation factor

apoptosis related protein APR-3

Related Diseases

Diseases

Alias

Cloacal Exstrophy

Oeis Complex	Omphalocele-Cloacal Exstrophy-Imperforate Anus-Spinal Defect Syndrome
Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects Compl	Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects Complex
Cloacal Exstrophy Sequence	Omphalocele - Cloacal Exstrophy - Imperforate Anus - Spinal Defect
Omphalocele, Exstrophy Of The Cloaca, Imperforate Anus, And Spinal Defects	Omphalocele Exstrophy Imperforate Anus

Congenital Syphilis

Syphilis, Congenital	Congenital Syphilis, Unspecified
Mtct Of Syphilis	Mother-To-Child Transmission Of Syphilis
Syphilis Congenital	Hereditary Syphilis
Heredosyphilis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01248	ATRAID Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ATRAID	VGNC	VGNC:38294
Bos taurus	ATRAID	VGNC	VGNC:54408
Felis catus	ATRAID	VGNC	VGNC:60033
Macaca mulatta	ATRAID	VGNC	VGNC:106132
Rattus norvegicus	ATRAID	RGD	RGD:1311605
Mus musculus	ATRAID	MGD	MGI:1918918

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