ANGPT4 - angiopoietin 4 Gene

Homo sapiens

Also known as ANG3; ANG4

Gene ID: 51378 | Gene type: protein coding

About ANGPT4

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:869,900-916,334 (from NCBI)

This gene has 1 transcript (splice variant), 189 orthologues and 25 paralogues. Biased expression in fat (RPKM 1.7), ovary (RPKM 1.2) and 11 other tissues.

Summary

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All Angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The mechanism by which they contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting perivascular cells. The protein encoded by this gene functions as an agonist and is an angiopoietin. [provided by RefSeq, Jul 2008]

ANGPT4 Products(2)

mRNA	Protein	Name
NM_001322809.2	NP_001309738.1	angiopoietin-4 isoform 2 precursor
NM_015985.4	NP_057069.1	angiopoietin-4 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables receptor tyrosine kinase binding	IDA IDA: Inferred from direct assay	10051567	GOA
enables transmembrane receptor protein tyrosine kinase activator activity	IDA IDA: Inferred from direct assay	10051567	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	12958144	GOA
NOT involved in endothelial cell proliferation	IDA IDA: Inferred from direct assay	10025962	GOA
involved in negative regulation of angiogenesis	IDA IDA: Inferred from direct assay	16790085	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	12958144	GOA
involved in negative regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	16790085	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	15284220	GOA
involved in positive regulation of blood vessel endothelial cell migration	IDA IDA: Inferred from direct assay	15284220	GOA
involved in positive regulation of endothelial cell migration	IDA IDA: Inferred from direct assay	12958144	GOA
involved in positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	15851516	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10025962	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGPT4 Protein Structure

Fibrinogen_C

0
100
200
300
400
503 a.a.

Protein Preferred Names

Protein Names

angiopoietin-4

Recombinant ANGPT4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74411	Angiopoietin-4 Protein, Human (HEK293, Fc)	Q9Y264-1 (M282-I503)	≥95%

Related Diseases

Diseases

Alias

Angiosarcoma

Hemangiosarcoma

Glaucoma 3, Primary Congenital, A

Buphthalmos	Glaucoma, Congenital
Congenital Glaucoma	Glaucoma 3a, Primary Open Angle, Congenital, Juvenile, Or Adult Onset
GLC3A	Glc3
Buphthalmia	Primary Congenital Glaucoma
Glaucoma, Primary Open Angle, Juvenile-Onset	Simple Buphthalmos
Buphthalmus	Glaucoma, Primary Open Angle, Adult-Onset
Primary Congenital Glaucoma 3a	Primary Infantile Glaucoma Type 3a
Glaucoma 3a, Primary Congenital	Glaucoma, Congenital, Primary, Type 3a
Hydrophthalmos	Cystic Eyeball

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00689	ANGPT4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ANGPT4	VGNC	VGNC:37856
Bos taurus	ANGPT4	VGNC	VGNC:25889
Macaca mulatta	ANGPT4	VGNC	VGNC:69812
Rattus norvegicus	ANGPT4	RGD	RGD:1307539
Felis catus	ANGPT4	VGNC	VGNC:67557
Mus musculus	ANGPT4	MGD	MGI:1336887
Others	ANGPT4	NCBI

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