PDE4A - phosphodiesterase 4A Gene

Homo sapiens

Also known as PDE4; DPDE2; PDE46

Gene ID: 5141 | Gene type: protein coding

About PDE4A

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,416,773-10,469,631 (from NCBI)

This gene has 9 transcripts (splice variants), 261 orthologues and 20 paralogues. Ubiquitous expression in testis (RPKM 5.3), brain (RPKM 5.3) and 24 other tissues.

Summary

The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE4 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

PDE4A Products(13)

mRNA	Protein	Name
NM_001111308.1	NP_001104778.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 2
XM_047438910.1	XP_047294866.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X2
XM_047438912.1	XP_047294868.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X4
XM_047438911.1	XP_047294867.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X3
XM_047438914.1	XP_047294870.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X7
XM_047438915.1	XP_047294871.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X8
NM_001243121.2	NP_001230050.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 5
XM_011528055.4	XP_011526357.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X5
NM_006202.3	NP_006193.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 4
NM_001111307.2	NP_001104777.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 1
XM_017026865.3	XP_016882354.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X1
XM_047438913.1	XP_047294869.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform X6
NM_001111309.1	NP_001104779.1	cAMP-specific 3',5'-cyclic phosphodiesterase 4A isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3',5'-cyclic-AMP phosphodiesterase activity	IDA IDA: Inferred from direct assay	7888306	GOA
enables 3',5'-cyclic-AMP phosphodiesterase activity	IGI IGI: Inferred from genetic interaction	8413254	GOA
enables cAMP binding	IGI IGI: Inferred from genetic interaction	8413254	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11306681	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cAMP catabolic process	IDA IDA: Inferred from direct assay	7888306	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	7888306	GOA
located in extrinsic component of membrane	IDA IDA: Inferred from direct assay	9677330	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11306681	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDE4A Protein Structure

PDEase_I

0
200
400
600
800
864 a.a.

Protein Preferred Names

Protein Names

cAMP-specific 3',5'-cyclic phosphodiesterase 4A

phosphodiesterase 4A, cAMP-specific (dunce	phosphodiesterase E2 dunce homolog, Drosophila
phosphodiesterase isozyme 4

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Asthma

Chronic Obstructive Asthma	Asthma, Diminished Response To Antileukotriene Treatment In
Bronchial Hyperreactivity	Asthma, Susceptibility To
Asthma, Bronchial	Asthma, Protection Against
Asthma, Nocturnal, Susceptibility To	Nocturnal Asthma
Asthma-Related Traits	Asthma-Related Traits, Susceptibility To
Asthma, Nocturnal	Chronic Obstructive Asthma With Acute Exacerbation
Chronic Obstructive Asthma With Status Asthmaticus	Exercise Induced Asthma
Exercise-Induced Asthma	Bronchial Asthma
Asthma, Exercise-Induced	Idiosyncratic Asthma
Unspecified Asthma With Acute Exacerbation	Asthma, Unspecified, With Stated Status Asthmaticus
Status Asthmaticus Nos	Acute Severe Asthma
Acute Severe Bronchial Asthma	Status Asthma
Status Post Asthmaticus

Acrodysostosis

Acrodysplasia	Arkless-Graham Syndrome
Maroteaux-Malamut Syndrome	Nasal Hypoplasia-Peripheral Dysostosis-Intellectual Disability Syndrome
Peripheral Dysostosis-Nasal Hypoplasia-Intellectual Disability Syndrome

Impotence

Erectile Dysfunction	Sexual Impotence
Erectile Dysfunction Adverse Event

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behet'S Syndrome
Bd Syndrome	Behçet Syndrome
Behçet'S Disease	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Brain Oligodendroglioma

Oligodendroglioma Of Brain

Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To	Psoriatic Arthropathy
Arthropathic Psoriasis	Arthritis, Psoriatic
Arthritis Psoriatica	PSORAS
Arthritic Psoriasis	Psoriasis Arthropathica
Arthritis Psoriatic	Arthritis, Psoriatic, Susceptibility To

Skin Disease

Skin Diseases	Abnormality Of The Skin
Skin Diseases, Genetic	Genodermatosis
Skin And Subcutaneous Tissue Disease	Dermatologic Disorders

Osteoporosis

Postmenopausal Osteoporosis	Osteoporosis, Postmenopausal
Bone Mineral Density Quantitative Trait Locus	Bmnd
Osteoporosis, Involutional	Osteoporosis, Susceptibility To
Osteoporosis, Postmenopausal, Susceptibility	Bone Mineral Density Variation Qtl, Osteoporosis
OSTEOP	Involutional Osteoporosis
Senile Osteoporosis	Osteoporosis Postmenopausal
Bone Mineral Density, Quantitative Trait Locus	Osteoporosis, Senile
Idiopathic Osteoporosis	Bone Rarefaction Nos
Type 1 Osteoporosis

Psoriasis

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia	B-Cell Chronic Lymphocytic Leukemia
CLL	B-Cell Chronic Lymphoid Leukemia
Chronic Lymphatic Leukemia	Chronic Lymphocytic Leukaemia
Lymphoplasmacytic Leukemia	Small Lymphocytic Lymphoma
Leukemia, Chronic Lymphatic	B-Cell Chronic Lymphocytic Leukaemia
Chronic Lymphatic Leukaemia	Lymphoplasmacytic Leukaemia
B Cell Chronic Lymphocytic Leukemia	Chronic B-Cell Lymphocytic Leukemia
Leukemia, Lymphocytic, Chronic	B-Cll
Chronic Lymphoid Leukemia	Leukemia Lymphocytic Chronic
Lymphoma Small Lymphocytic	Leukemia, Lymphocytic, Chronic, B-Cell

Pulmonary Disease, Chronic Obstructive

Chronic Obstructive Pulmonary Disease	COPD
Pulmonary Disease, Chronic Obstructive, Severe Early-Onset	Chronic Obstructive Lung Disease
Chronic Obstructive Airway Disease	Pulmonary Disease, Chronic Obstructive, Susceptibility To
Cold	Severe Early-Onset Chronic Obstructive Pulmonary Disease
Pulmonary Disease Chronic Obstructive	Pulmonary Disease, Obstructive, Chronic, Susceptibility To
Chronic Obstructive Pulmonary Disease Of Horses	Common Cold
Upper Respiratory Infections	Copd - [Chronic Obstructive Pulmonary Disease]
Coad - [Chronic Obstructive Airways Disease]	Cold - [Chronic Obstructive Lung Disease]
Chronic Airway Disease Nos	Chronic Airways Limitation, Unspecified
Chronic Obstructed Airway, Unspecified	Chronic Obstructive Airway Disease, Unspecified
Chronic Obstructive Airway, Unspecified	Obstructive Lung Disease Nos
Chronic Obstructive Lung Disease Nos	Chronic Obstructive Lung Nos
Obstructive Pulmonary Disease Nos	Exacerbation Copd Nos
Acute Exacerbation Copd

Dermatitis, Atopic

Atopic Dermatitis	Atopic Eczema
Dermatitis, Atopic, Susceptibility To, 1	Atod
Eczema, Atopic	Dermatitis, Atopic 1
Allergic Dermatitis	Atopic Neurodermatitis
Besnier'S Prurigo	Dermatitis, Atopic, 1
Dermatitis Atopic	Eczema
Besnier Prurigo

Respiratory Failure

Acute Respiratory Failure	Chronic Respiratory Failure
Respiratory Insufficiency	Acute-On-Chronic Respiratory Failure
Acute And Chronic Respiratory Failure	Respiratory Insufficiency/Failure
Chronic Respiratory Disease	Respiratory Disease
Pulmonary Valve Insufficiency	Chronic Disease Of Respiratory System
Respiration Disorders	Respiratory Tract Diseases
Lung Failure Nos	Pulmonary Failure
Arf - [Acute Respiratory Failure]	Acute Respiratory Insufficiency
Acute Pulmonary Insufficiency	Acute Respiration Failure
Chronic Respiration Failure

Skin Sarcoidosis

Cutaneous Sarcoidosis	Cutaneous Sarcoid
Sarcoidosis Of Skin

Ocular Hypotension

Hypotony Of Eye

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Microphthalmia, Isolated 1

Isolated Microphthalmia 1	MCOP1
Mcop	Anophthalmia, Clinical, Isolated
Microphthalmos, Autosomal Recessive

Nasopharyngitis

Chronic Nasopharyngitis

Chronic Rhinopharyngitis

Pulmonary Eosinophilia

Asthmatic Pulmonary Eosinophilia	Eosinophilic Lung Infiltrate
Weingarten'S Syndrome

Mood Disorder

Mood Disorders

Episodic Mood Disorder

Pleurisy

Multiple Sclerosis

MS	Multiple Sclerosis, Susceptibility To
Disseminated Sclerosis	Multiple Sclerosis, Disease Progression, Modifier Of
Insular Sclerosis	Multiple Sclerosis Modifier Of Disease Progression
Multiple Sclerosis, Susceptibility To 1	Multiple Sclerosis, Susceptibility To, 1
Multiple Sclerosis 1	Generalized Multiple Sclerosis
Multiple Sclerosis Variant	Multiple Sclerosis Susceptibility To
Cerebrospinal Sclerosis	Generalised Multiple Sclerosis
Ms - [Multiple Sclerosis]	Disseminated Cerebrospinal Sclerosis
Disseminated Multiple Sclerosis	Disseminated Nervous System Myelosclerosis
Multiple Cerebrospinal Sclerosis	Multiple Combined Sclerosis
Multiple Sclerosis Generalised	Disseminated Brain Sclerosis
Disseminated Spinal Sclerosis	Insular Brain Sclerosis
Miliary Brain Sclerosis	Multiple Combined Sclerosis Of Spinal Cord
Multiple Ascending Sclerosis	Multiple Brain Sclerosis
Multiple Sclerosis Of Brain Stem	Multiple Sclerosis Of The Brain Stem
Multiple Sclerosis Of Cord	Sclérose En Plaques
Plaque Sclerosis	Multiple Sclerosis Of The Spinal Cord

Pulmonary Hypertension

Primary Pulmonary Hypertension	Hypertension Pulmonary
Hypertension, Pulmonary	Idiopathic Pulmonary Hypertension
Idiopathic Pulmonary Arterial Hypertension	Pulmonary Htn - [Hypertension]

Autoimmune Disease Of Skin And Connective Tissue

Chromosome 16p13.3 Deletion Syndrome, Proximal

Rubinstein-Taybi Syndrome	Broad Thumb-Hallux Syndrome
Chromosome 16p13.3 Deletion Syndrome	Rubinstein-Taybi Syndrome Due To 16p13.3 Microdeletion
Rubinstein Syndrome	Broad Thumbs-Halluces Syndrome
Rsts	Rubinstein-Taybi Deletion Syndrome
Rsts Deletion Syndrome	Proximal Chromosome 16p13.3 Deletion Syndrome
16p13.3 Deletion Syndrome	Broad Thumbs And Great Toes, Characteristic Facies, And Mental Retardation
Rts

Exercise-Induced Bronchoconstriction

Exercise-Induced Asthma

Asthma Exercise-Induced

Alzheimer Disease, Familial, 1

Alzheimer Disease	Alzheimer'S Disease
Presenile And Senile Dementia	AD1
Alzheimer Disease, Susceptibility To	Alzheimer Disease, Late-Onset, Susceptibility To
Alzheimer Disease 1, Familial	AD
Familial Alzheimer Disease	Alzheimer Disease, Late-Onset
Alzheimers Dementia	Alzheimer Dementia
Alzheimer Sclerosis	Alzheimer Syndrome
Alzheimer-Type Dementia	Dat
Primary Senile Degenerative Dementia	Sdat
Alzheimer Disease 1	Autosomal Dominant Alzheimer Disease
Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy	Late Onset Alzheimer Disease
Alzheimers Disease	Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy
Late-Onset Alzheimers Disease	Alzheimer'S Disease Pathway Kegg
Dementia Due To Alzheimer'S Disease	Alzheimer Disease Type 1
Alzheimers

Bronchial Disease

Bronchial Diseases	Bronchial Disorders
Bronchial Spasm

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B1639	Enoximone	Inhibitor	98.07%	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-16900	Rolipram	Inhibitor	99.58%	Phase 2
HY-106003	GSK356278	Inhibitor	99.82%	Phase 1

Pre-clinical Phase

Bioactive Molecules (9)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16900A	(R)-(-)-Rolipram	Inhibitor	99.89%	Unkown
HY-119190	PF-06445974	Inhibitor	98.23%	Unkown
HY-103050	ML-030	Inhibitor	99.50%	Unkown
HY-131707	LEO 39652	Inhibitor	99.51%	Unkown
HY-131340	LASSBio-1632	Inhibitor	/	Unkown
HY-122167	L-869298	Inhibitor	/	Unkown
HY-RS10220	PDE4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10221	Pde4a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS10222	Pde4a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PDE4A	VGNC	VGNC:75915
Canis familiaris	PDE4A	VGNC	VGNC:44353
Mus musculus	PDE4A	MGD	MGI:99558
Rattus norvegicus	PDE4A	RGD	RGD:3279
Bos taurus	PDE4A	VGNC	VGNC:55071
Felis catus	PDE4A	VGNC	VGNC:68758