VGLL1 - vestigial like family member 1 Gene

Homo sapiens

Also known as TDU; VGL1

Gene ID: 51442 | Gene type: protein coding

About VGLL1

Cytogenetic location: Xq26.3 Genomic coordinates (GRCh38): X:136,532,215-136,556,799 (from NCBI)

This gene has 4 transcripts (splice variants), 104 orthologues and 2 paralogues. Restricted expression toward placenta (RPKM 103.1).

Summary

The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. [provided by RefSeq, Sep 2009]

VGLL1 Products(1)

mRNA	Protein	Name
NM_016267.4	NP_057351.1	transcription cofactor vestigial-like protein 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20211142	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VGLL1 Protein Structure

Vg_Tdu

0
100
200
258 a.a.

Protein Preferred Names

Protein Names

transcription cofactor vestigial-like protein 1

TONDU

VGLL1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	VGLL1	Q99990	TEAD3	Homo sapiens	Q99594	Y2H Prey Pooling	32296183
Intra	VGLL1	Q99990	TEAD3	Homo sapiens	Q99594	Y2H Array	32296183
Intra	VGLL1	Q99990	AIRIM	Homo sapiens	Q9NX04	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

46,Xy Sex Reversal 8

SRXY8	Male Pseudohermaphroditism Due To Deficiency Of Testicular 17,20-Desmolase
Tdd	46,Xy Disorder Of Sex Development Due To Testicular 17,20-Desmolase Deficiency
46xy Sex Reversal 8	46xy Sex Reversal 8, Modifier Of
Male Pseudohermaphroditism: Deficiency Of Testicular 17,20-Desmolase

Sveinsson Chorioretinal Atrophy

SCRA	Atrophia Areata
Helicoid Peripapillary Chorioretinal Degeneration	Hpcd
Aa	Peripapillary Chorioretinal Degeneration, Icelandic Type
Helicoidal Peripapillary Chorioretinal Degeneration	Atrophy, Chorioretinal, Sveinsson

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15644	VGLL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	VGLL1	VGNC	VGNC:56958
Felis catus	VGLL1	VGNC	VGNC:82514
Mus musculus	VGLL1	MGD	MGI:2655768
Canis familiaris	VGLL1	VGNC	VGNC:48257
Rattus norvegicus	VGLL1	RGD	RGD:1564038

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