RHCG - Rh family C glycoprotein Gene

Homo sapiens

Also known as RHGK; PDRC2; C15orf6; SLC42A3

Gene ID: 51458 | Gene type: protein coding

About RHCG

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:89,471,407-89,496,583 (from NCBI)

This gene has 7 transcripts (splice variants), 297 orthologues and 4 paralogues. Restricted expression toward esophagus (RPKM 1491.4).

Summary

Enables ammonium transmembrane transporter activity; ankyrin binding activity; and identical protein binding activity. Involved in ammonium transmembrane transport; cellular ion homeostasis; and transepithelial ammonium transport. Located in apical plasma membrane and basolateral plasma membrane. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RHCG Products(2)

mRNA	Protein	Name
NM_001321041.2	NP_001307970.1	ammonium transporter Rh type C
NM_016321.3	NP_057405.1	ammonium transporter Rh type C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ammonium channel activity	IDA IDA: Inferred from direct assay	14761968	GOA
enables ammonium channel activity	IGI IGI: Inferred from genetic interaction	11062476	GOA
enables ankyrin binding	IDA IDA: Inferred from direct assay	12719424	GOA
enables carbon dioxide transmembrane transporter activity	IDA IDA: Inferred from direct assay	24077989	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	20457942	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ammonium transmembrane transport	IDA IDA: Inferred from direct assay	14761968	GOA
involved in ammonium transmembrane transport	IGI IGI: Inferred from genetic interaction	11062476	GOA
involved in intracellular monoatomic ion homeostasis	IDA IDA: Inferred from direct assay	14761968	GOA
involved in transepithelial ammonium transport	IDA IDA: Inferred from direct assay	18032481	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16928804	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16928804	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10852913	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHCG Protein Structure

Ammonium_transp

0
100
200
300
400
479 a.a.

Protein Preferred Names

Protein Names

ammonium transporter Rh type C

Rh type C glycoprotein

Related Diseases

Diseases

Alias

Hemolytic Disease Of Fetus And Newborn, Rh-Induced

Rh Deficiency Syndrome	Rh Disease
HDFNRH	Rh Fetomaternal Incompatibility
Rh-Null Syndrome

Overhydrated Hereditary Stomatocytosis

Ohs	Potassium Sodium Disorder Of Erythrocyte
OHST	Stomatocytosis I
Potassium-Sodium Disorder Of Erythrocyte	Stomatocytosisiohst
Hereditary, Overhydrated, Cation-Leak Stomatocytosis	Overhydrated Cation Leak Stomatocytosis
Stomatocytosis, Overhydrated Hereditary

Renal Tubular Acidosis

Acidosis Renal Tubular	Acidosis, Renal Tubular
Lightwood-Albright Syndrome	Lightwood Syndrome
Idiopathic Infantile Hypercalcemia - Mild Form	Kidney Tubular Acidosis
Renal Tubule Acidosis	Kidney Acidosis
Renal Acidosis	Renal Hyperchloremic Acidosis
Rta - [Renal Tubular Acidosis]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11940	RHCG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	RHCG	RGD	RGD:727859
Bos taurus	RHCG	VGNC	VGNC:33938
Felis catus	RHCG	VGNC	VGNC:64608
Mus musculus	RHCG	MGD	MGI:1888517
Macaca mulatta	RHCG	VGNC	VGNC:84427
Canis familiaris	RHCG	VGNC	VGNC:45550
Others	RHCG	NCBI

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