HACD3 - 3-hydroxyacyl-CoA dehydratase 3 Gene

Homo sapiens

Also known as BIND1; B-IND1; HSPC121; PTPLAD1

Gene ID: 51495 | Gene type: protein coding

About HACD3

Cytogenetic location: 15q22.31 Genomic coordinates (GRCh38): 15:65,530,463-65,578,349 (from NCBI)

This gene has 12 transcripts (splice variants), 261 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 49.9), adrenal (RPKM 46.4) and 25 other tissues.

Summary

Enables 3-hydroxyacyl-CoA dehydratase activity and Enzyme binding activity. Involved in fatty acid biosynthetic process; positive regulation by virus of viral protein levels in host cell; and positive regulation of viral genome replication. Located in endoplasmic reticulum and nuclear membrane. [provided by Alliance of Genome Resources, Apr 2022]

HACD3 Products(2)

mRNA	Protein	Name
NM_001411136.1	NP_001398065.1	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 isoform 2
NM_016395.4	NP_057479.2	very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables enzyme binding	IDA IDA: Inferred from direct assay	18554506	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18160438	GOA
enables very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity	IDA IDA: Inferred from direct assay	18554506	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in fatty acid elongation	IDA IDA: Inferred from direct assay	18554506	GOA
involved in positive regulation by virus of viral protein levels in host cell	IMP IMP: Inferred from mutant phenotype	18160438	GOA
involved in positive regulation of viral genome replication	IMP IMP: Inferred from mutant phenotype	18160438	GOA
involved in very long-chain fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	18554506	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	18554506	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HACD3 Protein Structure

PTPLA

0
100
200
300
362 a.a.

Protein Preferred Names

Protein Names

very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3

butyrate-induced protein 1

HACD3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	HACD3	Q9P035	Q03463-PRO_0000278740	Hepatitis C virus	Q03463-PRO_0000278740	Anti Tag CoIP	18160438

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 34

Erythrokeratodermia With Ataxia	Spinocerebellar Ataxia Type 34
SCA34	Erythrokeratodermia - Ataxia
Giroux Barbeau Syndrome	Spinocerebellar Ataxia And Erythrokeratodermia
Erythrokeratodermia Ataxia

Fiedler'S Myocarditis

Isolated Myocarditis	Fiedler Myocarditis
Idiopathic Myocarditis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05986	HACD3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HACD3	VGNC	VGNC:73225
Felis catus	HACD3	VGNC	VGNC:62746
Bos taurus	HACD3	VGNC	VGNC:29738
Canis familiaris	HACD3	VGNC	VGNC:54310
Mus musculus	HACD3	MGD	MGI:1889341
Rattus norvegicus	HACD3	RGD	RGD:1565496

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