2. Gene
  3. CTDSPL2 - CTD small phosphatase like 2 Gene

CTDSPL2 - CTD small phosphatase like 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as SCP4; HSPC058; HSPC129

Gene ID: 51496 | Gene type: protein coding

About CTDSPL2

Cytogenetic location: 15q15.3-q21.1 Genomic coordinates (GRCh38): 15:44,427,629-44,529,038 (from NCBI)

This gene has 11 transcripts (splice variants), 281 orthologues and 5 paralogues. Ubiquitous expression in lymph node (RPKM 7.7), testis (RPKM 7.5) and 25 other tissues.

Summary

Enables RNA polymerase II CTD heptapeptide repeat Phosphatase activity. Predicted to act upstream of or within negative regulation of BMP signaling pathway; positive regulation of protein export from nucleus; and protein dephosphorylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CTDSPL2 Products(1)

mRNA Protein Name
NM_016396.3 NP_057480.2 CTD small phosphatase-like protein 2
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables RNA polymerase II CTD heptapeptide repeat phosphatase activity IDA
IDA: Inferred from direct assay
26920047 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTDSPL2 Protein Structure

NIF

NIF: NLI interacting factor-like phosphatase (289 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 466 a.a.
Protein Preferred Names Protein Names

CTD small phosphatase-like protein 2

CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase like 2

CTDSPL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CTDSPL2 Q05D32 PDIK1L Homo sapiens Q8N165
Validated Y2H
32296183
Intra
CTDSPL2 Q05D32 PDIK1L Homo sapiens Q8N165
Y2H Prey Pooling
32296183
Intra
CTDSPL2 Q05D32 PDIK1L Homo sapiens Q8N165
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03294 CTDSPL2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus CTDSPL2 VGNC VGNC:27792
Rattus norvegicus CTDSPL2 RGD RGD:1309219
Canis familiaris CTDSPL2 VGNC VGNC:39695
Macaca mulatta CTDSPL2 VGNC VGNC:71593
Felis catus CTDSPL2 VGNC VGNC:80993
Mus musculus CTDSPL2 MGD MGI:1196405