2. Gene
  3. PDIK1L - PDLIM1 interacting kinase 1 like Gene

PDIK1L - PDLIM1 interacting kinase 1 like Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CLIK1L; STK35L2

Gene ID: 149420 | Gene type: protein coding

About PDIK1L

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,111,162-26,125,555 (from NCBI)

This gene has 4 transcripts (splice variants), 203 orthologues and 8 paralogues. Ubiquitous expression in thyroid (RPKM 7.2), bone marrow (RPKM 4.5) and 25 other tissues.

Summary

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in meiotic cell cycle. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

PDIK1L Products(3)

mRNA Protein Name
NM_001243532.2 NP_001230461.1 serine/threonine-protein kinase PDIK1L
NM_001243533.2 NP_001230462.1 serine/threonine-protein kinase PDIK1L
NM_152835.5 NP_690048.1 serine/threonine-protein kinase PDIK1L
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22939624 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDIK1L Protein Structure

Pkinase

Pkinase: Protein kinase domain (8 - 324)

  • 0
  • 100
  • 200
  • 300
  • 341 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase PDIK1L

casein kinase

PDIK1L Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra PDIK1L Q8N165 CTDSPL2 Homo sapiens Q05D32
Anti Tag CoIP
33961781
Intra PDIK1L Q8N165 CTDSPL2 Homo sapiens Q05D32
Y2H Array
32296183
Intra PDIK1L Q8N165 CTDSPL2 Homo sapiens Q05D32
Anti Tag CoIP
28514442
Intra PDIK1L Q8N165 CTDSPL2 Homo sapiens Q05D32
Y2H Prey Pooling
32296183
Intra PDIK1L Q8N165 CTDSPL2 Homo sapiens Q05D32
Pull Down
32707033
Intra PDIK1L Q8N165 CDC37 Homo sapiens Q16543
Pull Down
32707033
Intra PDIK1L Q8N165 CDC37 Homo sapiens Q16543
Lumier
25036637
Intra PDIK1L Q8N165 CDC37 Homo sapiens Q16543
Anti Tag CoIP
33961781
Intra PDIK1L Q8N165 CDC37 Homo sapiens Q16543
Anti Tag CoIP
28514442
Intra PDIK1L Q8N165 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra PDIK1L Q8N165 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
33961781
Intra PDIK1L Q8N165 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
28514442
Intra PDIK1L Q8N165 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra PDIK1L Q8N165 C1orf174 Homo sapiens Q8IYL3
Y2H Array
32296183
Intra PDIK1L Q8N165 C1orf174 Homo sapiens Q8IYL3
Anti Tag CoIP
28514442
Intra PDIK1L Q8N165 C1orf174 Homo sapiens Q8IYL3
Pull Down
32707033
Intra PDIK1L Q8N165 C1orf174 Homo sapiens Q8IYL3
Y2H Prey Pooling
32296183
Intra PDIK1L Q8N165 DAZAP2 Homo sapiens Q15038
Y2H Array
32296183
Intra PDIK1L Q8N165 DAZAP2 Homo sapiens Q15038
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Axenfeld-Rieger Syndrome, Type 1

Axenfeld-Rieger Syndrome Type 1

RIEG1

Rieg

Rgs

Rieger Syndrome Type 1

Rieger Syndrome, Type 1

Axenfeld-Rieger Syndrome 1

Iridogoniodysgenesis With Somatic Anomalies
Acromesomelic Dysplasia 2c

Acromesomelic Dysplasia, Hunter-Thompson Type

Acromesomelic Dysplasia 2c, Hunter-Thompson Type

AMD2C

Acromesomelic Dwarfism

Amdh Acromesomelic Dwarfism

Acromesomelic Dysplasia-2c

Acromesomelic Dysplasia Hunter Thompson Type

Acromesomelic Chondrodysplasia, Hunter-Thompson Type

Amdh

Dysplasia, Acromesomelic, Type 2c, Hunter-Thompson

Acromesomelic Dysplasia Hunter-Thompson Type
Nail Disorder, Nonsyndromic Congenital, 4

Anonychia Congenita

Anonychia

Hyponychia Congenita

NDNC4

Anonychia/Hyponychia Congenita

Nonsyndromic Congenital Nail Disorder 4

Isolated Congenital Anonychia

Anonychia Congenita Totalis

Anonychia Totalis

Autosomal Recessive Nonsyndromic Congenital Nail Disorder-4

Congenital Anonychia

Nonsyndromic Congenital Nail Disorder, 4

Absent Nails

Aplastic Nails

Congenital Absence Of Nails

Isolated Anonychia

Nail Disorder, Non-Syndromic Congenital, 4

Nail Disorder, Nonsyndromic, Congenital, Type 4
Nonsyndromic Congenital Nail Disorder

Nail Disorder, Nonsyndromic Congenital
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148063 DB0614 98.80% Unkown
HY-148061 DB1113 99.28% Unkown
HY-RS10272 PDIK1L Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta PDIK1L VGNC VGNC:75830
Bos taurus PDIK1L VGNC VGNC:32701
Mus musculus PDIK1L MGD MGI:2385213
Canis familiaris PDIK1L VGNC VGNC:44379
Rattus norvegicus PDIK1L RGD RGD:1307476
Felis catus PDIK1L VGNC VGNC:64087