RTF2 - replication termination factor 2 Gene

Homo sapiens

Also known as CDAO5; RTFDC1; HSPC164; C20orf43; SHUJUN-3

Gene ID: 51507 | Gene type: protein coding

About RTF2

This gene has 9 transcripts (splice variants) and 209 orthologues. Ubiquitous expression in brain (RPKM 40.3), bone marrow (RPKM 39.0) and 25 other tissues.

Summary

Enables DNA binding activity. Involved in cellular response to hydroxyurea and regulation of DNA stability. Located in replication fork. [provided by Alliance of Genome Resources, Apr 2022]

RTF2 Products(4)

mRNA	Protein	Name
NM_001283035.2	NP_001269964.1	replication termination factor 2 isoform a
NM_001283036.2	NP_001269965.1	replication termination factor 2 isoform c
NM_001283037.2	NP_001269966.1	replication termination factor 2 isoform d
NM_016407.5	NP_057491.2	replication termination factor 2 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	29290612	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29290612	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hydroxyurea	IMP IMP: Inferred from mutant phenotype	29290612	GOA
involved in regulation of DNA stability	IMP IMP: Inferred from mutant phenotype	29290612	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in replication fork	IDA IDA: Inferred from direct assay	29290612	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTF2 Protein Structure

Rtf2

0
100
200
300
336 a.a.

Protein Preferred Names

Protein Names

replication termination factor 2

UPF0549 protein C20orf43

RTF2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RTF2	Q9BY42	FLNC	Homo sapiens	Q14315	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Amyotrophic Lateral Sclerosis 7

ALS7	Amyotrophic Lateral Sclerosis Type 7

Trichosporonosis

Retinitis Pigmentosa 39

RP39	Retinitis Pigmentosa, Type 39

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12319	RTF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RTF2	VGNC	VGNC:45788
Rattus norvegicus	RTF2	RGD	RGD:1311072
Bos taurus	RTF2	VGNC	VGNC:34196
Mus musculus	RTF2	MGD	MGI:1913654
Macaca mulatta	RTF2	VGNC	VGNC:77018

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