2. Gene
  3. DTL - denticleless E3 ubiquitin protein ligase homolog Gene

DTL - denticleless E3 ubiquitin protein ligase homolog Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CDT2; RAMP; DCAF2; L2DTL

Gene ID: 51514 | Gene type: protein coding

About DTL

Cytogenetic location: 1q32.3 Genomic coordinates (GRCh38): 1:212,035,748-212,105,013 (from NCBI)

This gene has 6 transcripts (splice variants) and 206 orthologues. Broad expression in testis (RPKM 9.8), bone marrow (RPKM 8.4) and 15 other tissues.

Summary

Contributes to ubiquitin-protein transferase activity. Involved in several processes, including protein ubiquitination; regulation of G2/M transition of mitotic cell cycle; and translesion synthesis. Located in centrosome; cytosol; and nuclear lumen. Part of Cul4A-RING E3 ubiquitin Ligase complex and Cul4B-RING E3 ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DTL Products(3)

mRNA Protein Name
NM_001286229.2 NP_001273158.2 denticleless protein homolog isoform 2
NM_001286230.2 NP_001273159.2 denticleless protein homolog isoform 3
NM_016448.4 NP_057532.4 denticleless protein homolog isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16949367 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: Inferred from direct assay
18794347 GOA
Biological Process GO Annotation Evidence Reference Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
20129063 GOA
involved in DNA damage response IMP
IMP: Inferred from mutant phenotype
16949367 GOA
involved in mitotic G2 DNA damage checkpoint signaling IMP
IMP: Inferred from mutant phenotype
17085480 GOA
involved in positive regulation of G2/M transition of mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
16949367 GOA
involved in positive regulation of protein catabolic process IMP
IMP: Inferred from mutant phenotype
16949367 GOA
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
20129063 GOA
involved in protein polyubiquitination IDA
IDA: Inferred from direct assay
18794347 GOA
involved in regulation of cell cycle IMP
IMP: Inferred from mutant phenotype
17085480 GOA
involved in response to UV IDA
IDA: Inferred from direct assay
18794347 GOA
involved in translesion synthesis IDA
IDA: Inferred from direct assay
20129063 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
18794347 GOA
involved in ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
26431207 GOA
Cellular Component GO Annotation Evidence Reference Source
part of Cul4-RING E3 ubiquitin ligase complex IMP
IMP: Inferred from mutant phenotype
16949367 GOA
part of Cul4A-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
17085480 GOA
part of Cul4B-RING E3 ubiquitin ligase complex IDA
IDA: Inferred from direct assay
18794347 GOA
located in centrosome IDA
IDA: Inferred from direct assay
17106265 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17106265 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DTL Protein Structure

WD40

WD40: WD domain, G-beta repeat (89 - 126)

WD40

WD40: WD domain, G-beta repeat (130 - 169)

WD40

WD40: WD domain, G-beta repeat (308 - 345)

WD40

WD40: WD domain, G-beta repeat (350 - 388)

  • 0
  • 200
  • 400
  • 600
  • 730 a.a.
Protein Preferred Names Protein Names

denticleless protein homolog

DDB1- and CUL4-associated factor 2

DTL Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
DTL Q9NZJ0 DDB1 Homo sapiens Q16531
Anti Tag CoIP
17041588
Intra
DTL Q9NZJ0 DDB1 Homo sapiens Q16531
Anti Tag CoIP
33961781
Intra
DTL Q9NZJ0 DDB1 Homo sapiens Q16531
Anti Bait CoIP
17041588
Intra
DTL Q9NZJ0 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Myasthenic Syndrome, Congenital, 8

Congenital Myasthenic Syndrome 8

CMS8

Myasthenic Syndrome, Congenital, With Pre- And Postsynaptic Defects

Cmsppd

Myasthenic Syndrome, Congenital, 8, With Pre- And Postsynaptic Defects

Congenital Myasthenic Syndrome Due To Agrin Deficiency

Myasthenic Syndrome, Congenital, Due To Agrin Deficiency

Congenital Myasthenic Syndrome 8 With Pre- And Postsynaptic Defects

Myasthenic Syndrome, Congenital, Type 8, With Pre- And Postsynaptic Defects
Branchiootorenal Syndrome 1

Melnick-Fraser Syndrome

BOR1

Branchiootorenal Dysplasia

Branchiootorenal Syndrome 1, With Or Without Cataracts

Bor Syndrome 1

Branchiootorenal Dysplasia 1

Branchio-Oto-Renal Dysplasia 1

Branchio-Oto-Renal Syndrome Type 1

Branchiootorenal Syndrome, With/Without Cataract, Type 1

Branchio-Oto-Renal Syndrome
Cockayne Syndrome A

Cockayne Syndrome Type 1

Cockayne Syndrome, Type A

Cockayne Syndrome Type I

CSA

Cockayne Syndrome Classic Form

Cockayne Syndrome Classical

Cockayne Syndrome Type A

Ckn1
Xeroderma Pigmentosum Group E

Xeroderma Pigmentosum, Group E

Xeroderma Pigmentosum V

Xp Group E

Xp5

Xpe

Xeroderma Pigmentosum, Complementation Group E
Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum

XPV

Xeroderma Pigmentosum Variant Type

Xeroderma Pigmentosum With Normal Dna Repair Rates

Photosensitivity With Defective Dna Synthesis

Xp

De Sanctis-Cacchione Syndrome

Desanctis-Cacchione Syndrome

Xeroderma Pigmentosa

Xerodermic Idiocy

Xeroderma Pigmentosum Variant

Xp - [Xeroderma Pigmentosum]

Atrophoderma Pigmentosum
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04034 DTL Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus DTL RGD RGD:1310439
Bos taurus DTL VGNC VGNC:28230
Canis familiaris DTL VGNC VGNC:40113
Felis catus DTL VGNC VGNC:61642
Macaca mulatta DTL VGNC VGNC:71992
Mus musculus DTL MGD MGI:1924093
Macaca fascicularis DTL NCBI NCBI:102118760
Others DTL NCBI