TDP2 - tyrosyl-DNA phosphodiesterase 2 Gene

Homo sapiens

Also known as EAP2; AD022; EAPII; TTRAP; hTDP2; dJ30M3.3

Gene ID: 51567 | Gene type: protein coding

About TDP2

Cytogenetic location: 6p22.3 Genomic coordinates (GRCh38): 6:24,649,979-24,666,899 (from NCBI)

This gene has 5 transcripts (splice variants), 272 orthologues and is associated with 2 phenotypes. Broad expression in small intestine (RPKM 97.5), colon (RPKM 87.6) and 24 other tissues.

Summary

This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF Receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 Endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]

TDP2 Products(1)

mRNA	Protein	Name
NM_016614.3	NP_057698.2	tyrosyl-DNA phosphodiesterase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 5'-tyrosyl-DNA phosphodiesterase activity	IDA IDA: Inferred from direct assay	19794497	GOA
enables 5'-tyrosyl-DNA phosphodiesterase activity	IMP IMP: Inferred from mutant phenotype	21030584	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	22405347	GOA
enables manganese ion binding	IDA IDA: Inferred from direct assay	22822062	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18039968	GOA
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	22822062	GOA
enables tyrosyl-RNA phosphodiesterase activity	IDA IDA: Inferred from direct assay	22908287	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in double-strand break repair	IDA IDA: Inferred from direct assay	19794497	GOA
involved in double-strand break repair	IMP IMP: Inferred from mutant phenotype	21030584	GOA
involved in neuron development	IMP IMP: Inferred from mutant phenotype	24658003	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in PML body	IDA IDA: Inferred from direct assay	19794497	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	22908287	GOA
located in nucleus	IDA IDA: Inferred from direct assay	22908287	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TDP2 Protein Structure

UBA_4

Exo_endo_phos

0
100
200
300
362 a.a.

Protein Preferred Names

Protein Names

tyrosyl-DNA phosphodiesterase 2

5'-Tyr-DNA phosphodiesterase

TDP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TDP2	O95551	DNM2	Homo sapiens	P50570-2	Y2H Pooling	32814053
Intra	TDP2	O95551	DNM2	Homo sapiens	P50570-2	Validated Y2H	32814053
Intra	TDP2	O95551	DNM2	Homo sapiens	P50570-2	Y2H Array	32814053
Intra	TDP2	O95551	BLK	Homo sapiens	P51451	Validated Y2H	32296183
Intra	TDP2	O95551	ATXN3	Homo sapiens	P54252	Y2H Array	32814053
Intra	TDP2	O95551	ATXN3	Homo sapiens	P54252	Validated Y2H	32814053
Intra	TDP2	O95551	ATXN3	Homo sapiens	P54252	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia, Autosomal Recessive 23

SCAR23	Autosomal Recessive Spinocerebellar Ataxia 23
Autosomal Recessive Cerebellar Ataxia-Epilepsy-Intellectual Disability Syndrome Due To Tud Deficiency	Autosomal Recessive Cerebellar Ataxia - Epilepsy - Intellectual Disability Syndrome Due To Tud Deficiency
Spinocerebellar Ataxia Autosomal Recessive Type 23	Spinocerebellar Ataxia, Autosomal Recessive, 23
Ataxia, Spinocerebellar, Autosomal Recessive, Type 23

Aceruloplasminemia

Cerebellar Ataxia	Hypoceruloplasminemia
Hemosiderosis, Systemic, Due To Aceruloplasminemia	Familial Apoceruloplasmin Deficiency
Hereditary Ceruloplasmin Deficiency	Deficiency Of Ferroxidase
Hypoceruloplasminemia, Hereditary	Ceruloplasmin Deficiency
Systemic Hemosiderosis Due To Aceruloplasminemia	ACERULOP

Spinocerebellar Ataxia Type 1 With Axonal Neuropathy

Scan1	Spinocerebellar Ataxia With Axonal Neuropathy Type 1
Autosomal Recessive Spinocerebellar Ataxia With Axonal Neuropathy	Scan1, Tdp1-Related Spinocerebellar Ataxia With Axonal Neuropathy
Spinocerebellar Ataxia Autosomal Recessive With Axonal Neuropathy	Spinocerebellar Ataxia With Axonal Neuropathy
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy	Ataxia, Spinocerebellar, Autosomal Recessive With Axonal Neuropathy

Ruijs-Aalfs Syndrome

Progeroid Features-Hepatocellular Carcinoma Predisposition Syndrome

RJALS

Reading Disorder

Specific Reading Disorder	Reading
Dyslexia	Developmental Reading Disorder

Paralytic Poliomyelitis

Poliomyelitis, Paralytic

Learning Disability

Learning Disabilities	Learning Disorders
Academic Skill Disorder	Learning Disorder

Specific Language Impairment

Language Impairment, Specific

Dyslexia

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14333	TDP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TDP2	VGNC	VGNC:35714
Macaca mulatta	TDP2	VGNC	VGNC:78403
Felis catus	TDP2	VGNC	VGNC:97658
Canis familiaris	TDP2	VGNC	VGNC:47219
Mus musculus	TDP2	MGD	MGI:1860486
Rattus norvegicus	TDP2	RGD	RGD:1560342

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