PDK2 - pyruvate dehydrogenase kinase 2 Gene

Homo sapiens

Also known as PDHK2; PDKII

Gene ID: 5164 | Gene type: protein coding

About PDK2

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:50,094,737-50,112,152 (from NCBI)

This gene has 16 transcripts (splice variants), 236 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 32.6), heart (RPKM 32.6) and 24 other tissues.

Summary

This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both Cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

PDK2 Products(4)

mRNA	Protein	Name
NM_001199898.2	NP_001186827.1	pyruvate dehydrogenase kinase, isozyme 2 isoform 2
NM_001199899.2	NP_001186828.1	pyruvate dehydrogenase kinase, isozyme 2 isoform 2
NM_001199900.2	NP_001186829.1	pyruvate dehydrogenase kinase, isozyme 2 isoform 3 precursor
NM_002611.5	NP_002602.2	pyruvate dehydrogenase kinase, isozyme 2 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	16401071	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19833728	GOA
enables pyruvate dehydrogenase (acetyl-transferring) kinase activity	IDA IDA: Inferred from direct assay	19833728	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to reactive oxygen species	IMP IMP: Inferred from mutant phenotype	21283817	GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator	IMP IMP: Inferred from mutant phenotype	22123926	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDK2 Protein Structure

BCDHK_Adom3

HATPase_c

0
100
200
300
407 a.a.

Protein Preferred Names

Protein Names

pyruvate dehydrogenase kinase, isozyme 2

PDH kinase 2

PDK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PDK2	Q15119	HTT	Homo sapiens	P42858	Y2H Pooling	16169070

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Esophageal Adenosquamous Carcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-121744	PS10	Inhibitor	99.01%	Unkown
HY-19564	JX06		99.78%	Unkown
HY-12492	VER-246608	Inhibitor	98.92%	Unkown
HY-18676B	ILK-IN-2		99.41%	Unkown
HY-RS10276	PDK2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PDK2	MGD	MGI:1343087
Felis catus	PDK2	VGNC	VGNC:97550
Macaca mulatta	PDK2	VGNC	VGNC:75933
Canis familiaris	PDK2	VGNC	VGNC:44381
Bos taurus	PDK2	VGNC	VGNC:32704
Rattus norvegicus	PDK2	RGD	RGD:69428

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