CMPK1 - cytidine/uridine monophosphate kinase 1 Gene

Homo sapiens

Also known as CK; CMK; UMK; CMPK; UMPK; UMP-CMPK

Gene ID: 51727 | Gene type: protein coding

About CMPK1

Cytogenetic location: 1p33 Genomic coordinates (GRCh38): 1:47,333,790-47,378,839 (from NCBI)

This gene has 7 transcripts (splice variants), 125 orthologues and 9 paralogues. Ubiquitous expression in colon (RPKM 74.1), duodenum (RPKM 71.2) and 25 other tissues.

Summary

This gene encodes one of the Enzymes required for cellular nucleic acid biosynthesis. This Enzyme catalyzes the transfer of a phosphate group from ATP to CMP, UMP, or dCMP, to form the corresponding diphosphate nucleotide. Alternate splicing results in both coding and non-coding transcript variants. [provided by RefSeq, Feb 2012]

CMPK1 Products(3)

mRNA	Protein	Name
NM_001136140.2	NP_001129612.1	UMP-CMP kinase isoform b
NM_001366135.1	NP_001353064.1	UMP-CMP kinase isoform c
NM_016308.3	NP_057392.1	UMP-CMP kinase isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables UMP kinase activity	IDA IDA: Inferred from direct assay	11912132	GOA
enables nucleoside diphosphate kinase activity	IDA IDA: Inferred from direct assay	23416111	GOA
enables nucleoside monophosphate kinase activity	EXP EXP: Inferred from Experiment	40615	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in UDP biosynthetic process	IDA IDA: Inferred from direct assay	11912132	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CMPK1 Protein Structure

ADK

0
100
200
228 a.a.

Protein Preferred Names

Protein Names

UMP-CMP kinase

UMP/CMP kinase

Recombinant CMPK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77273	UMP-CMP kinase/CMPK1 Protein, Human (sf9, His)	P30085-1 (M1-G196)	≥95%

Related Diseases

Diseases

Alias

Astrakhan Spotted Fever

Nemaline Myopathy 2

NEM2	Nemaline Myopathy 2, Autosomal Recessive
Nemaline Myopathy, Type 2	Neb-Related Nemaline Myopathy
Myopathy, Nemaline, Type 2

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02861	CMPK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CMPK1	RGD	RGD:1310116
Bos taurus	CMPK1	VGNC	VGNC:27480
Mus musculus	CMPK1	MGD	MGI:1913838
Canis familiaris	CMPK1	VGNC	VGNC:39379
Felis catus	CMPK1	VGNC	VGNC:80170
Others	CMPK1	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.