ARID4B - AT-rich interaction domain 4B Gene

Homo sapiens

Also known as BCAA; BRCAA1; RBP1L1; SAP180; RBBP1L1

Gene ID: 51742 | Gene type: protein coding

About ARID4B

Cytogenetic location: 1q42.3 Genomic coordinates (GRCh38): 1:235,166,902-235,328,179 (from NCBI)

This gene has 13 transcripts (splice variants), 218 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 12.1), lymph node (RPKM 11.3) and 25 other tissues.

Summary

This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, Apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast Cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]

ARID4B Products(3)

mRNA	Protein	Name
NM_001206794.2	NP_001193723.1	AT-rich interactive domain-containing protein 4B isoform 1
NM_016374.6	NP_057458.4	AT-rich interactive domain-containing protein 4B isoform 1
NM_031371.4	NP_112739.2	AT-rich interactive domain-containing protein 4B isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	EXP EXP: Inferred from Experiment	33675746	GOA
enables DNA binding	IMP IMP: Inferred from mutant phenotype	33675746	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	20195357	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARID4B Protein Structure

RBB1NT

ARID

Tudor-knot

0
300
600
900
1200
1312 a.a.

Protein Preferred Names

Protein Names

AT-rich interactive domain-containing protein 4B

180 kDa Sin3-associated polypeptide

Related Diseases

Diseases

Alias

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00972	ARID4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ARID4B	VGNC	VGNC:38099
Bos taurus	ARID4B	VGNC	VGNC:26130
Rattus norvegicus	ARID4B	RGD	RGD:619919
Mus musculus	ARID4B	MGD	MGI:2137512
Felis catus	ARID4B	VGNC	VGNC:59917
Macaca mulatta	ARID4B	VGNC	VGNC:69831

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