2. Gene
  3. ATP5ME - ATP synthase membrane subunit e Gene

ATP5ME - ATP synthase membrane subunit e Gene

  • Gene
  • Protein
Homo sapiens (human)

Also known as ATP5I; ATP5K

Gene ID: 521 | Gene type: protein coding

About ATP5ME

Summary

Mitochondrial ATP Synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during Oxidative Phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the Other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the e subunit of the Fo complex. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jun 2010]

ATP5ME Products(1)

mRNA Protein Name
NR_033743.2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
contributes to proton-transporting ATP synthase activity, rotational mechanism IDA
IDA: Inferred from direct assay
12110673 GOA
Biological Process GO Annotation Evidence Reference Source
involved in proton motive force-driven mitochondrial ATP synthesis IDA
IDA: Inferred from direct assay
12110673 GOA
Cellular Component GO Annotation Evidence Reference Source
part of proton-transporting ATP synthase complex IDA
IDA: Inferred from direct assay
12110673 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP synthase subunit e, mitochondrial

ATP synthase e chain, mitochondrial

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit E

ATP synthase, H+ transporting, mitochondrial Fo complex subunit E

ATPase subunit e

F1F0-ATP synthase, murine e subunit

ATP5ME Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ATP5ME P56385 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
Intra
ATP5ME P56385 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
Intra
ATP5ME P56385 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
Intra
ATP5ME P56385 SPG21 Homo sapiens Q9NZD8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction