2. Gene
  3. PFN2 - profilin 2 Gene

PFN2 - profilin 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PFL; D3S1319E

Gene ID: 5217 | Gene type: protein coding

About PFN2

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,964,904-149,970,895 (from NCBI)

This gene has 18 transcripts (splice variants), 278 orthologues and 2 paralogues. Broad expression in brain (RPKM 148.4), thyroid (RPKM 50.8) and 19 other tissues.

Summary

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]

PFN2 Products(2)

mRNA Protein Name
NM_002628.5 NP_002619.1 profilin-2 isoform b
NM_053024.4 NP_444252.1 profilin-2 isoform a

PFN2 Protein Structure

Profilin

Profilin: Profilin (3 - 135)

  • 0
  • 100
  • 140 a.a.
Protein Preferred Names Protein Names

profilin-2

profilin II

Recombinant PFN2 Proteins

Cat. No. Product Name Accession Purity
HY-P71237 Profilin-2 Protein, Human P35080-1 (M1-F140) ≥95%
HY-P73698 Profilin-2 Protein, Human (His) AAH18049.1 (M1-F140) ≥95%

Related Diseases

Diseases Alias
Charcot-Marie-Tooth Disease

Cmt

Hmsn

Hereditary Motor And Sensory Neuropathy

Pma

Cmt - Charcot-Marie-Tooth Disease

Charcot Marie Tooth Disease

Charcot-Marie-Tooth Hereditary Neuropathy

Charcot-Marie-Tooth Syndrome

Peroneal Muscular Atrophy

Hereditary Motor And Sensory Neuropathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10369 PFN2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PFN2 VGNC VGNC:102803
Canis familiaris PFN2 VGNC VGNC:49940
Rattus norvegicus PFN2 RGD RGD:621826
Bos taurus PFN2 VGNC VGNC:32776
Mus musculus PFN2 MGD MGI:97550
Others PFN2 NCBI