PFN2 - profilin 2 Gene

Homo sapiens

Also known as PFL; D3S1319E

Gene ID: 5217 | Gene type: protein coding

About PFN2

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,964,904-149,970,895 (from NCBI)

This gene has 18 transcripts (splice variants), 278 orthologues and 2 paralogues. Broad expression in brain (RPKM 148.4), thyroid (RPKM 50.8) and 19 other tissues.

Summary

The protein encoded by this gene is a ubiquitous actin monomer-binding protein belonging to the profilin family. It is thought to regulate actin polymerization in response to extracellular signals. There are two alternatively spliced transcript variants encoding different isoforms described for this gene. [provided by RefSeq, Jul 2008]

PFN2 Products(2)

mRNA	Protein	Name
NM_002628.5	NP_002619.1	profilin-2 isoform b
NM_053024.4	NP_444252.1	profilin-2 isoform a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	7758455	GOA
enables actin monomer binding	IPI IPI: Inferred from physical interaction	7758455	GOA
enables phosphatidylinositol-4,5-bisphosphate binding	IDA IDA: Inferred from direct assay	7758455	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9822597	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of actin filament polymerization	IDA IDA: Inferred from direct assay	7758455	GOA
involved in negative regulation of epithelial cell migration	IMP IMP: Inferred from mutant phenotype	23153535	GOA
involved in negative regulation of ruffle assembly	IMP IMP: Inferred from mutant phenotype	23153535	GOA
involved in positive regulation of ATP-dependent activity	IDA IDA: Inferred from direct assay	7758455	GOA
involved in positive regulation of actin filament bundle assembly	IMP IMP: Inferred from mutant phenotype	23153535	GOA
involved in positive regulation of actin filament polymerization	IGI IGI: Inferred from genetic interaction	23153535	GOA
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	23153535	GOA
involved in positive regulation of stress fiber assembly	IMP IMP: Inferred from mutant phenotype	23153535	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	18573880	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PFN2 Protein Structure

Profilin

0
100
140 a.a.

Protein Preferred Names

Protein Names

profilin-2

profilin II

Recombinant PFN2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71237	Profilin-2 Protein, Human	P35080-1 (M1-F140)	≥95%
HY-P73698	Profilin-2 Protein, Human (His)	AAH18049.1 (M1-F140)	≥95%

Related Diseases

Diseases

Alias

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10369	PFN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PFN2	VGNC	VGNC:102803
Canis familiaris	PFN2	VGNC	VGNC:49940
Rattus norvegicus	PFN2	RGD	RGD:621826
Bos taurus	PFN2	VGNC	VGNC:32776
Mus musculus	PFN2	MGD	MGI:97550
Others	PFN2	NCBI

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