PHF2 - PHD finger protein 2 Gene

Homo sapiens

Also known as GRC5; KDM7C; JHDM1E; CENP-35

Gene ID: 5253 | Gene type: protein coding

About PHF2

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:93,576,584-93,679,587 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 4 paralogues. Ubiquitous expression in ovary (RPKM 14.2), endometrium (RPKM 13.4) and 25 other tissues.

Summary

This gene encodes a protein which contains a zinc finger-like PHD (plant homeodomain) finger, distinct from other classes of zinc finger motifs, and a hydrophobic and highly conserved domain. The PHD finger shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. [provided by RefSeq, Jul 2008]

PHF2 Products(1)

mRNA	Protein	Name
NM_005392.4	NP_005383.3	lysine-specific demethylase PHF2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone H3K9 demethylase activity	IDA IDA: Inferred from direct assay	21532585	GOA
NOT enables histone demethylase activity	IDA IDA: Inferred from direct assay	21167174	GOA
enables iron ion binding	IDA IDA: Inferred from direct assay	21167174	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	20129925	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21532585	GOA
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	21532585	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	20129925	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of rDNA heterochromatin formation	IMP IMP: Inferred from mutant phenotype	20129925	GOA
involved in protein demethylation	IDA IDA: Inferred from direct assay	21532585	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in kinetochore	IDA IDA: Inferred from direct assay	20813266	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	20129925	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PHF2 Protein Structure

PHD

JmjC

0
200
400
600
800
1000
1096 a.a.

Protein Preferred Names

Protein Names

lysine-specific demethylase PHF2

centromere protein 35

Related Diseases

Diseases

Alias

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10420	PHF2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PHF2	VGNC	VGNC:68822
Macaca mulatta	PHF2	VGNC	VGNC:75974
Bos taurus	PHF2	VGNC	VGNC:32818
Canis familiaris	PHF2	VGNC	VGNC:44484
Mus musculus	PHF2	MGD	MGI:1338034
Rattus norvegicus	PHF2	RGD	RGD:1305228

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