Suz12 - SUZ12 polycomb repressive complex 2 subunit Gene

Mus musculus

Also known as mKIAA0160; D11Ertd530e; 2610028O16Rik

Gene ID: 52615 | Gene type: protein coding

About Suz12

Summary

This gene encodes a core component of the polycomb repressive complex 2 (PRC2) that also includes, at least, embryonic ectoderm development protein (EED) and enhancer of zeste homolog 1 or 2 (EZH1 or EZH2). Through the methyltransferase activity of EZH1 or EZH2, the PRC2 complex methylates Lys9 and Lys27 of histone 3 and Lys26 of histone 1, leading to recruitment of the PRC1 complex, histone 2A ubiquitylation and transcriptional repression of the target genes. This gene product is essential for the activity and integrity of the PRC2 complex, and is required for X chromosome inactivation, stem cell maintenance and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009]

Suz12 Products(2)

mRNA	Protein	Name
NM_001163018.1	NP_001156490.1	polycomb protein Suz12 isoform 2
NM_199196.2	NP_954666.1	polycomb protein Suz12 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA binding	IPI IPI: Inferred from physical interaction	22911650	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	24268575	MGI
enables chromatin DNA binding	IDA IDA: Inferred from direct assay	18483221	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	16687444	MGI
enables lncRNA binding	IPI IPI: Inferred from physical interaction	28041882	MGI
enables promoter-specific chromatin binding	IDA IDA: Inferred from direct assay	22770845	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20064375	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20956546	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15385962	MGI
acts upstream of or within chromatin organization	IMP IMP: Inferred from mutant phenotype	16359901	MGI
involved in facultative heterochromatin formation	IDA IDA: Inferred from direct assay	20064375	MGI
acts upstream of or within gene expression	IGI IGI: Inferred from genetic interaction	28041882	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	16687444	MGI
acts upstream of or within oligodendrocyte differentiation	IMP IMP: Inferred from mutant phenotype	28041882	MGI
acts upstream of or within positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15385962	MGI
acts upstream of or within random inactivation of X chromosome	IMP IMP: Inferred from mutant phenotype	27892467	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of ESC/E(Z) complex	IDA IDA: Inferred from direct assay	20064375	MGI
part of chromatin silencing complex	IDA IDA: Inferred from direct assay	26658965	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18483221	MGI
part of protein-DNA complex	IDA IDA: Inferred from direct assay	18483221	MGI
part of ribonucleoprotein complex	IPI IPI: Inferred from physical interaction	28041882	MGI
located in sex chromatin	IDA IDA: Inferred from direct assay	15525528	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

polycomb protein Suz12

suppressor of zeste 12 homolog

suppressor of zeste 12 protein homolog

Suz12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Suz12	Q80U70	Jarid2	Mus musculus	Q62315	Anti Bait CoIP	20064376
Intra	Suz12	Q80U70	Jarid2	Mus musculus	Q62315	Anti Bait CoIP	20064375
Intra	Suz12	Q80U70	Jarid2	Mus musculus	Q62315	Pull Down	20064375
Intra	Suz12	Q80U70	Ezh2	Mus musculus	Q6AXH7	Pull Down	23624931
Intra	Suz12	Q80U70	Ezh2	Mus musculus	Q61188	Anti Bait CoIP	24074865
Intra	Suz12	Q80U70	Ezh2	Mus musculus	Q61188	Anti Bait CoIP	20064375
Intra	Suz12	Q80U70	Ezh2	Mus musculus	Q61188	Anti Bait CoIP	20064376

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-101512	A-395	Inhibitor	99.12%	Unkown
HY-W014099	Boc-NH-C4-acid		99.85%	Unkown
HY-157164	PROTAC EZH2 Degrader-2	Degrader	99.78%	Unkown
HY-158239	MS181	Inhibitor	98.36%	Unkown
HY-130638	(S,R,S)-AHPC-O-Ph-PEG1-NH-Boc		/	Unkown
HY-130637	Boc-NH-PEG1-Ph-O-CH2COOH		/	Unkown
HY-RS14053	SUZ12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Suz12	NCBI	NCBI:23512

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