PLA2G1B - phospholipase A2 group IB Gene

Homo sapiens

Also known as PLA2; PLA2A; PPLA2

Gene ID: 5319 | Gene type: protein coding

About PLA2G1B

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:120,322,115-120,327,779 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues and 8 paralogues. Restricted expression toward pancreas (RPKM 9662.9).

Summary

This gene encodes a secreted member of the Phospholipase A2 (PLA2) class of Enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent Enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic Enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The Enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]

PLA2G1B Products(1)

mRNA	Protein	Name
NM_000928.3	NP_000919.1	phospholipase A2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	7060561	GOA
enables calcium-dependent phospholipase A2 activity	IDA IDA: Inferred from direct assay	1420353	GOA
enables phospholipase A2 activity	IDA IDA: Inferred from direct assay	1918029	GOA
enables signaling receptor binding	IDA IDA: Inferred from direct assay	1918029	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	7721806	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	12860195	GOA
involved in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA IDA: Inferred from direct assay	12860195	GOA
involved in defense response to Gram-positive bacterium	IDA IDA: Inferred from direct assay	12860195	GOA
involved in fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	1918029	GOA
involved in innate immune response in mucosa	IDA IDA: Inferred from direct assay	12860195	GOA
involved in lipid catabolic process	IDA IDA: Inferred from direct assay	7060561	GOA
involved in phosphatidylcholine metabolic process	IDA IDA: Inferred from direct assay	7060561	GOA
involved in phosphatidylglycerol metabolic process	IDA IDA: Inferred from direct assay	1420353	GOA
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	1918029	GOA
involved in positive regulation of fibroblast proliferation	IDA IDA: Inferred from direct assay	1918029	GOA
involved in positive regulation of podocyte apoptotic process	IDA IDA: Inferred from direct assay	25335547	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	1918029	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	7060561	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G1B Protein Structure

Phospholip_A2_1

0
100
148 a.a.

Protein Preferred Names

Protein Names

phospholipase A2

phosphatidylcholine 2-acylhydrolase 1B

Recombinant PLA2G1B Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71071	PLA2G1B Protein, Human (HEK293, His)	P04054 (A23-S148)	≥95%

Related Diseases

Diseases

Alias

Blepharitis

Acute Pancreatitis

Pancreatitis	Pancreatitis, Acute Necrotizing
Pancreatitis Nos	Acute Pancreas Inflammation

Membranous Nephropathy

Membranous Glomerulonephritis	Glomerulonephritis, Membranous
Idiopathic Membranous Nephropathy	Idiopathic Membranous Glomerulonephritis
MBNP	Membranous Nephropathy, Susceptibility To
Extramembranous Glomerulonephritis	Mgn
Membranous Gn	Primary Membranous Glomerulonephritis
Primary Membranous Nephropathy	Nephropathy Membranous

Neurodegeneration With Brain Iron Accumulation 2b

NBIA2B	Neurodegeneration With Brain Iron Accumulation, Pla2g6-Related
Neuroaxonal Dystrophy, Atypical	Karak Syndrome
Atypical Neuroaxonal Dystrophy	Neurodegeneration With Brain Iron Accumulation Pla2g6-Related
Neurodegeneration, With Brain Iron Accumulation, Type 2b	Neurodegeneration With Brain Iron Accumulation 2

Neuroaxonal Dystrophy

Neuroaxonal Dystrophies

Neurodegeneration With Brain Iron Accumulation 2a

Infantile Neuroaxonal Dystrophy	Plan
Seitelberger Disease	Inad
Infantile Neuroaxonal Dystrophy 1	Inad1
Pla2g6-Associated Neurodegeneration	NBIA2A
Neuroaxonal Dystrophy, Infantile	Neurodegeneration, Pla2g6-Associated
Neurodegeneration With Brain Iron Accumulation, Pla2g6-Related	Phospholipase A2-Associated Neurodegeneration
Nbia2	Pla2g6-Related Disorders
Infantile Neuroaxonal Dystrophy/Atypical Neuroaxonal Dystrophy	Karak Syndrome, Included
Nbia2b	Neuroaxonal Dystrophy, Atypical
Neurodegeneration With Brain Iron Accumulation 2b	Nbia, Pla2g6-Related
Seitelberger'S Disease	Neurodegeneration Pla2g6-Associated
Dystrophy, Neuroaxonal, Infantile	Neurodegeneration, With Brain Iron Accumulation, Type 2a
Neuroaxonal Dystrophies	Neurodegeneration With Brain Iron Accumulation 2

Erythema Infectiosum

Fifth Disease	Slapped Cheek Syndrome
Parvovirus B19 Infection

Orange Allergy

Citrus Sinensis Fruit Allergy

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Membranoproliferative Glomerulonephritis

Mesangiocapillary Glomerulonephritis	Dense Deposit Disease
Membranoproliferative Glomerulonephritis Type 2	Primary Membranoproliferative Glomerulonephritis
Mesangiocapillary Glomerulonephritis, Type Ii	Glomerulonephritis, Membranoproliferative
Chronic Glomerulonephritis, Lobular	Lobular Glomerulonephritis
Ddd	Glomerulonephritis Membranoproliferative Type 2
Mpgn 2	Membranoproliferative Glomerulonephritis Type Ii
Mesangiocapillary Glomerulonephritis Type 2	Mpgn
Primary Mpgn	Glomerulonephritis Membranoproliferative
Membranoproliferative Glomerulonephritis, Type Ii

Schizophrenia

SCZD	Schizophrenia With Or Without An Affective Disorder
Schizophrenia 12	Schizophrenia, Susceptibility To
Schizophrenia-1	Dementia Praecox
Schizophrenia 1

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Aceruloplasminemia

Cerebellar Ataxia	Hypoceruloplasminemia
Hemosiderosis, Systemic, Due To Aceruloplasminemia	Familial Apoceruloplasmin Deficiency
Hereditary Ceruloplasmin Deficiency	Deficiency Of Ferroxidase
Hypoceruloplasminemia, Hereditary	Ceruloplasmin Deficiency
Systemic Hemosiderosis Due To Aceruloplasminemia	ACERULOP

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10620	PLA2G1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	PLA2G1B	VGNC	VGNC:76154
Bos taurus	PLA2G1B	VGNC	VGNC:106868
Canis familiaris	PLA2G1B	VGNC	VGNC:44622
Mus musculus	PLA2G1B	MGD	MGI:101842
Felis catus	PLA2G1B	VGNC	VGNC:80464
Rattus norvegicus	PLA2G1B	RGD	RGD:61949
Others	PLA2G1B	NCBI

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