PLXNB3 - plexin B3 Gene

Homo sapiens

Also known as PLEXR; PLXN6; PLEXB3

Gene ID: 5365 | Gene type: protein coding

About PLXNB3

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:153,764,249-153,779,341 (from NCBI)

This gene has 9 transcripts (splice variants), 172 orthologues and 8 paralogues. Broad expression in brain (RPKM 10.9), salivary gland (RPKM 4.4) and 16 other tissues.

Summary

The protein encoded by this gene is a member of the plexin family. It functions as a receptor for semaphorin 5A, and plays a role in axon guidance, invasive growth and cell migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

PLXNB3 Products(2)

mRNA	Protein	Name
NM_001163257.2	NP_001156729.1	plexin-B3 isoform 2
NM_005393.3	NP_005384.2	plexin-B3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell-cell adhesion mediator activity	IPI IPI: Inferred from physical interaction	16122393	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15184888	GOA
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	15218527	GOA
enables semaphorin receptor activity	IDA IDA: Inferred from direct assay	15218527	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell chemotaxis	IDA IDA: Inferred from direct assay	15218527	GOA
involved in homophilic cell adhesion via plasma membrane adhesion molecules	IDA IDA: Inferred from direct assay	16122393	GOA
involved in negative regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	20696765	GOA
involved in negative regulation of cell adhesion	IDA IDA: Inferred from direct assay	15218527	GOA
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20696765	GOA
involved in positive chemotaxis	IDA IDA: Inferred from direct assay	15218527	GOA
involved in positive regulation of endothelial cell proliferation	IMP IMP: Inferred from mutant phenotype	19850054	GOA
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	16122393	GOA
involved in semaphorin-plexin signaling pathway	IDA IDA: Inferred from direct assay	15218527	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	16122393	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLXNB3 Protein Structure

Sema

PSI

TIG

Plexin_cytopl

0
300
600
900
1200
1500
1800
1909 a.a.

Protein Preferred Names

Protein Names

plexin-B3

plexin 6

Related Diseases

Diseases

Alias

Glioma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10754	PLXNB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PLXNB3	VGNC	VGNC:68920
Canis familiaris	PLXNB3	VGNC	VGNC:44724
Mus musculus	PLXNB3	MGD	MGI:2154240
Rattus norvegicus	PLXNB3	RGD	RGD:1560615
Bos taurus	PLXNB3	VGNC	VGNC:33063
Macaca mulatta	PLXNB3	VGNC	VGNC:76189

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