FSCN1 - fascin actin-bundling protein 1 Gene

Homo sapiens

Also known as HSN; SNL; p55; FAN1

Gene ID: 6624 | Gene type: protein coding

About FSCN1

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:5,592,816-5,606,655 (from NCBI)

This gene has 5 transcripts (splice variants), 254 orthologues and 2 paralogues. Broad expression in brain (RPKM 42.7), placenta (RPKM 36.2) and 24 other tissues.

Summary

This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several MicroRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of Cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15. [provided by RefSeq, Sep 2011]

FSCN1 Products(1)

mRNA	Protein	Name
NM_003088.4	NP_003079.1	fascin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	8999969	GOA
enables actin filament binding	IDA IDA: Inferred from direct assay	8999969	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	9571235	GOA
involved in actin filament bundle assembly	IDA IDA: Inferred from direct assay	20393565	GOA
involved in cell migration	IMP IMP: Inferred from mutant phenotype	20393565	GOA
involved in cell motility	IDA IDA: Inferred from direct assay	9571235	GOA
involved in cell-cell junction assembly	IDA IDA: Inferred from direct assay	9571235	GOA
involved in establishment of apical/basal cell polarity	IDA IDA: Inferred from direct assay	9571235	GOA
involved in microspike assembly	IDA IDA: Inferred from direct assay	9571235	GOA
involved in microspike assembly	IMP IMP: Inferred from mutant phenotype	20137952	GOA
involved in parallel actin filament bundle assembly	IDA IDA: Inferred from direct assay	21685497	GOA
involved in positive regulation of extracellular matrix disassembly	IDA IDA: Inferred from direct assay	20137952	GOA
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	9571235	GOA
involved in positive regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	20137952	GOA
involved in positive regulation of lamellipodium assembly	IDA IDA: Inferred from direct assay	9571235	GOA
involved in positive regulation of podosome assembly	IDA IDA: Inferred from direct assay	20137952	GOA
involved in regulation of actin cytoskeleton organization	IDA IDA: Inferred from direct assay	20137952	GOA
involved in regulation of microvillus assembly	IDA IDA: Inferred from direct assay	9571235	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IDA IDA: Inferred from direct assay	3525578	GOA
located in cell projection membrane	IDA IDA: Inferred from direct assay	9571235	GOA
located in cell-cell junction	IDA IDA: Inferred from direct assay	9571235	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	9571235	GOA
located in cytoskeleton	IDA IDA: Inferred from direct assay	9571235	GOA
located in filopodium	IDA IDA: Inferred from direct assay	3525578	GOA
located in microspike	IDA IDA: Inferred from direct assay	3525578	GOA
located in microvillus	IDA IDA: Inferred from direct assay	9571235	GOA
located in podosome	IDA IDA: Inferred from direct assay	20137952	GOA
located in ruffle	IDA IDA: Inferred from direct assay	3525578	GOA
located in stress fiber	IDA IDA: Inferred from direct assay	3525578	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FSCN1 Protein Structure

Fascin

0
100
200
300
400
493 a.a.

Protein Preferred Names

Protein Names

fascin

55 kDa actin-bundling protein

Related Diseases

Diseases

Alias

Inverted Papilloma

Inverted Papilloma, Squamous Cell	Papilloma Inverted
Papilloma, Inverted	Inverted Squamous Cell Papilloma

Castleman Disease

Angiofollicular Ganglionic Hyperplasia	Angiofollicular Lymph Hyperplasia
Giant Lymph Node Hyperplasia	Castleman'S Disease
Angiofollicular Lymph Node Hyperplasia	Lymphoid Hamartoma
Benign Giant Lymphoma	Angiolymphoid Hyperplasia

Langerhans Cell Histiocytosis

Histiocytosis X	Lch
Langerhans Cell Granulomatosis	Langerhans-Cell Histiocytosis
Letterer-Siwe Disease	Hashimoto-Pritzger Disease
Histiocytosis, Langerhans-Cell	Langerhan'S Cell Histiocytosis
Letterer-Siwe Disease Involving Intra-Abdominal Lymph Nodes	Letterer-Siwe Disease Involving Intrapelvic Lymph Nodes
Letterer-Siwe Disease Involving Intrathoracic Lymph Nodes	Letterer-Siwe Disease Involving Lymph Nodes Of Axilla And Upper Limb
Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Involving Lymph Nodes Of Head, Face, And Neck
Letterer-Siwe Disease Involving Lymph Nodes Of Inguinal Region And Lower Limb	Letterer-Siwe Disease Involving Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Involving Spleen	Letterer-Siwe Disease Of Intra-Abdominal Lymph Nodes
Letterer-Siwe Disease Of Intrapelvic Lymph Nodes	Letterer-Siwe Disease Of Intrathoracic Lymph Nodes
Letterer-Siwe Disease Of Lymph Nodes Of Axilla And Upper Limb	Letterer-Siwe Disease Of Lymph Nodes Of Axilla And/Or Upper Limb
Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And Neck	Letterer-Siwe Disease Of Lymph Nodes Of Head, Face And/Or Neck
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region Amd/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And Lower Limb
Letterer-Siwe Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Letterer-Siwe Disease Of Lymph Nodes Of Multiple Sites
Letterer-Siwe Disease Of Spleen	Familial Letterer-Siwe Disease
Langerhans-Cell Histiocytosis Nos

Autosomal Recessive Nonsyndromic Deafness 36

Autosomal Recessive Deafness 36	Dfnb36
Deafness, Autosomal Recessive 36, With Or Without Vestibular Involvement	Deafness, Autosomal Recessive 36

Mirror Agnosia

Anaplastic Large Cell Lymphoma

Alcl	Cd30 Positive Anaplastic Large Cell Lymphoma
Ki-1 Positive Anaplastic Large Cell Lymphoma	Primary Systemic Alcl
Sacl	Ki-1+ Anaplastic Large Cell Lymphoma

Juvenile Xanthogranuloma

Multiple Eruptive Juvenile Xanthogranuloma	Naevoxanthoendothelioma
Xanthoma Neviforme	Xanthogranuloma, Juvenile

Reticulosarcoma

Histiocytic Lymphoma	Large-Cell Lymphomas
Lymphoma, Large-Cell	Lymphoma Large Cell
Diffuse Large B-Cell Lymphoma	Histiocytic Sarcoma

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Papilloma

Papillomatosis

Lymphoma

Lymphoid Cancer	Lymphomas
Lymphoid Cancers	Lymphoid Neoplasm
Lymphoma Nos	Nhl - [Non-Hodgkin Lymphoma]
Non-Hodgkin Lymphoma	Non-Hodgkin Lymphoma, Nos
Non-Hodgkin Malignant Lymphoma Nos

Histiocytic Sarcoma

Malignant Histiocytosis

Laryngeal Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Larynx	Squamous Cell Carcinoma Of Larynx
Squamous Cell Carcinoma Of The Larynx	Squamous Cell Carcinoma Of Head And Neck

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Usher Syndrome, Type I

USH1	Usher Syndrome Type 1
Us1	Usher Syndrome, Type 1b
Usher Syndrome Type 1e	Retinitis Pigmentosa And Congenital Deafness
Usher Syndrome, Type Ie	USH1E
Usher Syndrome, Type 1e	Usher Syndrome, Type 1a
Usher Syndrome, Type Ib	Usher Syndrome Type 1b
Usher Syndrome Type Ie	Usher Syndrome Type I
Usher 1	Usher Syndrome, Type 1
Ush1a	Usher Syndrome, Type I, French Variety
Usher Syndrome, Type Ia	Usher Syndrome 1b
USH1B	Usher'S Syndrome Type 1b
Usher Syndrome Type Ib	Ushib

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Lymphoma, Hodgkin, Classic

Hodgkin Lymphoma	Hodgkin Disease
Hodgkin'S Lymphoma	Hodgkins Lymphoma
Classic Hodgkin Lymphoma	CHL
Hodgkin Lymphoma, Susceptibility To	Hl
Hodgkin'S Sarcoma	Stage I Subdiaphragmatic Hodgkin Lymphoma
Stage Ii Subdiaphragmatic Hodgkin Lymphoma	Lymphoma, Hodgkin'S
Classic Hodgkin Disease	Hodgkin'S Disease
Lymphoma, Hodgkin, Susceptibility To	Hodgkin'S Disease Of Intrapelvic Lymph Nodes
Hodgkin'S Disease Of Lymph Nodes Of Inguinal Region And/Or Lower Limb	Malignant Lymphogranuloma
Malignant Lymphogranulomatosis	Malignant Hodgkin Lymphoma
Classical Hodgkin Lymphoma, Type Not Specified

Parkinson Disease 4, Autosomal Dominant

Autosomal Dominant Parkinson Disease 4	PARK4
Parkinson Disease 4, Autosomal Dominant Lewy Body	Parkinson Disease 4
Parkinson'S Disease 4	Autosomal Dominant Lewy Body Parkinson Disease 4
Autosomal Dominant Parkinson'S Disease 4	Parkinson Disease 4 Autosomal Dominant Lewy Body
Parkinson Disease Autosomal Dominant 4	Parkinson Disease Familial Type 4
Parkinson Disease, Type 4

Esophageal Cancer

Esophageal Carcinoma	Carcinoma Of Esophagus
Esophageal Squamous Cell Carcinoma, Somatic	Esophageal Carcinoma, Somatic
Esophagus Cancer	Gastric Cardia Adenocarcinoma
Esophageal Neoplasms	Esophageal Cancer, Somatic
Cancer Of Esophagus	Cancer Of Oesophagus
Carcinoma Of Oesophagus	Ca Lower Third Oesophagus
Ca Middle Third Oesophagus	Malignant Neoplasm Of Distal Third Of Esophagus
Malignant Neoplasm Of Lower Third Of Oesophagus	Malignant Neoplasm Of Middle Third Of Oesophagus
Malignant Neoplasm Of Proximal Third Of Esophagus	Malignant Neoplasm Of Upper Third Esophagus
Malignant Tumor Of Abdominal Esophagus	Malignant Tumor Of Distal Third Of Esophagus
Malignant Tumor Of Proximal Third Of Esophagus	Malignant Tumor Of The Middle Third Of The Esophagus
ESCR	Aerodigestive Tract Cancer
Escc	Esophageal Squamous Cell Carcinoma
Cancer, Esophageal	Malignant Neoplasm Of Esophagus
Squamous Cell Carcinoma Of Esophagus	Malignant Neoplasm Of Middle Third Of Esophagus

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05119	FSCN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FSCN1	VGNC	VGNC:29126
Rattus norvegicus	FSCN1	RGD	RGD:1583309
Mus musculus	FSCN1	MGD	MGI:1352745
Macaca mulatta	FSCN1	VGNC	VGNC:72714
Felis catus	FSCN1	VGNC	VGNC:80575
Canis familiaris	FSCN1	VGNC	VGNC:40990

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