RAB4B - RAB4B, member RAS oncogene family Gene

Homo sapiens

Gene ID: 53916 | Gene type: protein coding

About RAB4B

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,778,247-40,796,942 (from NCBI)

This gene has 8 transcripts (splice variants), 197 orthologues and 68 paralogues. Ubiquitous expression in brain (RPKM 18.9), spleen (RPKM 18.3) and 25 other tissues.

Summary

RAB proteins, such as RAB4B, are members of the Ras superfamily of small GTPases that are involved in vesicular trafficking (He et al., 2002 [PubMed 12450215]).[supplied by OMIM, Aug 2009]

RAB4B Products(1)

mRNA	Protein	Name
NM_016154.5	NP_057238.3	ras-related protein Rab-4B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTPase activity	IDA IDA: Inferred from direct assay	20534812	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in D-glucose import	IMP IMP: Inferred from mutant phenotype	19590752	GOA
involved in early endosome to Golgi transport	IDA IDA: Inferred from direct assay	36282215	GOA
involved in endosomal vesicle fusion	IDA IDA: Inferred from direct assay	20534812	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in early endosome membrane	IDA IDA: Inferred from direct assay	20534812	GOA
located in insulin-responsive compartment	IDA IDA: Inferred from direct assay	19590752	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19590752	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	19590752	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAB4B Protein Structure

Ras

0
100
200
213 a.a.

Protein Preferred Names

Protein Names

ras-related protein Rab-4B

ras-related GTP-binding protein 4b

RAB4B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	RAB4B	P61018	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	RAB4B	P61018	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	32296183
Intra	RAB4B	P61018	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	RAB4B	P61018	RABEP1	Homo sapiens	Q15276	Validated Y2H	32296183
Intra	RAB4B	P61018	RABEP1	Homo sapiens	Q15276	Y2H Array	32296183
Intra	RAB4B	P61018	RABEP1	Homo sapiens	Q15276	Y2H Prey Pooling	32296183
Intra	RAB4B	P61018	GARIN6	Homo sapiens	Q8NEG0	Y2H Prey Pooling	32296183
Intra	RAB4B	P61018	GARIN6	Homo sapiens	Q8NEG0	Validated Y2H	32296183
Intra	RAB4B	P61018	GARIN6	Homo sapiens	Q8NEG0	Y2H Array	32296183
Intra	RAB4B	P61018	EXOC5	Homo sapiens	O00471	Y2H Array	25416956
Intra	RAB4B	P61018	EXOC5	Homo sapiens	O00471	Y2H Array	32296183
Intra	RAB4B	P61018	EXOC5	Homo sapiens	O00471	Y2H Prey Pooling	25416956
Intra	RAB4B	P61018	EXOC5	Homo sapiens	O00471	Validated Y2H	25416956
Intra	RAB4B	P61018	EXOC5	Homo sapiens	O00471	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11570	RAB4B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RAB4B	MGD	MGI:105071
Canis familiaris	RAB4B	VGNC	VGNC:53756
Rattus norvegicus	RAB4B	RGD	RGD:620931

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