2. Gene
  3. VPS52 - VPS52 subunit of GARP complex Gene

VPS52 - VPS52 subunit of GARP complex Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ARE1; SAC2; SACM2L; dJ1033B10.5

Gene ID: 6293 | Gene type: protein coding

About VPS52

Cytogenetic location: 6p21.32 Genomic coordinates (GRCh38): 6:33,250,272-33,271,965 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele and 201 orthologues. Ubiquitous expression in thyroid (RPKM 15.7), testis (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes a protein that is similar to the yeast suppressor of actin mutations 2 gene. The yeast protein forms a subunit of the tetrameric Golgi-associated retrograde protein complex that is involved in vesicle trafficking from from both early and late endosomes, back to the trans-Golgi network. This gene is located on chromosome 6 in a head-to-head orientation with the gene encoding ribosomal protein S18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

VPS52 Products(4)

mRNA Protein Name
NM_001289174.2 NP_001276103.1 vacuolar protein sorting-associated protein 52 homolog isoform 2
NM_001289175.1 NP_001276104.1 vacuolar protein sorting-associated protein 52 homolog isoform 3
NM_001289176.1 NP_001276105.1 vacuolar protein sorting-associated protein 52 homolog isoform 4
NM_022553.6 NP_072047.4 vacuolar protein sorting-associated protein 52 homolog isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15878329 GOA
enables syntaxin binding IPI
IPI: Inferred from physical interaction
15878329 GOA
Biological Process GO Annotation Evidence Reference Source
involved in endocytic recycling IMP
IMP: Inferred from mutant phenotype
25799061 GOA
acts upstream of or within lysosomal transport IDA
IDA: Inferred from direct assay
25799061 GOA
Cellular Component GO Annotation Evidence Reference Source
part of EARP complex IDA
IDA: Inferred from direct assay
25799061 GOA
part of EARP complex IPI
IPI: Inferred from physical interaction
25799061 GOA
part of GARP complex IDA
IDA: Inferred from direct assay
25799061 GOA
located in Golgi apparatus IDA
IDA: Inferred from direct assay
15878329 GOA
located in membrane IDA
IDA: Inferred from direct assay
25799061 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
15878329 GOA
located in recycling endosome IDA
IDA: Inferred from direct assay
25799061 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

VPS52 Protein Structure

Vps52

Vps52: Vps52 / Sac2 family (1 - 476)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 598 a.a.
Protein Preferred Names Protein Names

vacuolar protein sorting-associated protein 52 homolog

SAC2 suppressor of actin mutations 2-like protein

VPS52 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
VPS52 Q8N1B4 CCHCR1 Homo sapiens Q8TD31-3
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 AAMP Homo sapiens C9JG97
Y2H Array
25416956
Intra
VPS52 Q8N1B4 AAMP Homo sapiens C9JG97
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 TPM3 Homo sapiens Q5VU62
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 TPM3 Homo sapiens Q5VU62
Y2H Array
25416956
Intra
VPS52 Q8N1B4 TPM3 Homo sapiens Q5VU62
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 KIAA1217 Homo sapiens Q5T5P2-6
Y2H Array
25416956
Intra
VPS52 Q8N1B4 BORCS6 Homo sapiens Q96GS4
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 VPS28 Homo sapiens Q548N1
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 VPS28 Homo sapiens Q548N1
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 VPS28 Homo sapiens Q548N1
Y2H Array
25416956
Intra
VPS52 Q8N1B4 CCDC146 Homo sapiens Q8IYE0-2
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 FAM184A Homo sapiens Q6P9G8
Y2H Array
25416956
Intra
VPS52 Q8N1B4 FAM184A Homo sapiens Q6P9G8
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 ATP6V1D Homo sapiens Q6PJ05
Y2H Array
25416956
Intra
VPS52 Q8N1B4 ATP6V1D Homo sapiens Q8N5Z9
Y2H Array
25416956
Intra
VPS52 Q8N1B4 HEATR1 Homo sapiens Q96ES5
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 CABP5 Homo sapiens Q9NP86
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 HEL-S-61 Homo sapiens V9HW29
Y2H Array
25416956
Intra
VPS52 Q8N1B4 MFAP1 Homo sapiens P55081
Y2H Array
25416956
Intra
VPS52 Q8N1B4 METTL13 Homo sapiens Q8N6R0
Y2H Array
25416956
Intra
VPS52 Q8N1B4 DNAJC11 Homo sapiens Q9NVH1
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 VPS50 Homo sapiens Q96JG6
Anti Tag CoIP
25799061
Intra
VPS52 Q8N1B4 VPS50 Homo sapiens Q96JG6
TAP
25799061
Intra
VPS52 Q8N1B4 VPS50 Homo sapiens Q96JG6
Anti Bait CoIP
25799061
Intra
VPS52 Q8N1B4 PRKAA1 Homo sapiens Q13131
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 PRKAA1 Homo sapiens Q13131
Y2H Array
25416956
Intra
VPS52 Q8N1B4 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 PRKAA2 Homo sapiens P54646
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 VPS51 Homo sapiens Q9UID3-1
TAP
25799061
Intra
VPS52 Q8N1B4 KLC3 Homo sapiens Q6P597
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 KLC3 Homo sapiens Q6P597
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 FAM110A Homo sapiens Q9BQ89
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 THAP11 Homo sapiens Q96EK4
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 RNF41 Homo sapiens Q9H4P4
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 RNF41 Homo sapiens Q9H4P4
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 HAUS1 Homo sapiens Q96CS2
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 TCP11L1 Homo sapiens Q9NUJ3
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 KANK2 Homo sapiens Q63ZY3
Y2H Array
25416956
Intra
VPS52 Q8N1B4 PPP1R18 Homo sapiens Q6NYC8
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 PPP1R18 Homo sapiens Q6NYC8
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 ZMAT2 Homo sapiens Q96NC0
Y2H Array
25416956
Intra
VPS52 Q8N1B4 ATP6V1D Homo sapiens Q9Y5K8
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 ATP6V1D Homo sapiens Q9Y5K8
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 LMO4 Homo sapiens P61968
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 LMO4 Homo sapiens P61968
Y2H Array
25416956
Intra
VPS52 Q8N1B4 TXN2 Homo sapiens Q99757
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 TXN2 Homo sapiens Q99757
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 DDX6 Homo sapiens P26196
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 NFKBIB Homo sapiens Q15653
Y2H Array
25416956
Intra
VPS52 Q8N1B4 NFKBIB Homo sapiens Q15653
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 TPM3 Homo sapiens P06753
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 TPM3 Homo sapiens P06753
Y2H Array
25416956
Intra
VPS52 Q8N1B4 NOP2 Homo sapiens P46087
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 NOP2 Homo sapiens P46087
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 NOP2 Homo sapiens P46087
Y2H Array
25416956
Intra
VPS52 Q8N1B4 TAB2 Homo sapiens Q9NYJ8
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 TRAF6 Homo sapiens Q9Y4K3
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 TXLNA Homo sapiens P40222
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 TXLNA Homo sapiens P40222
Y2H Array
25416956
Intra
VPS52 Q8N1B4 TRAF4 Homo sapiens Q9BUZ4
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 CDC5L Homo sapiens Q99459
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 TSSK3 Homo sapiens Q96PN8
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 TSSK3 Homo sapiens Q96PN8
Y2H Array
25416956
Intra
VPS52 Q8N1B4 TSSK3 Homo sapiens Q96PN8
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 SMARCE1 Homo sapiens Q969G3
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 MRPL1 Homo sapiens Q9BYD6
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 MRPL11 Homo sapiens Q9Y3B7
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 TXLNB Homo sapiens Q8N3L3
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 GOLGA1 Homo sapiens Q92805
Y2H Array
25416956
Intra
VPS52 Q8N1B4 GOLGA1 Homo sapiens Q92805
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 EPM2AIP1 Homo sapiens Q7L775
Y2H Array
25416956
Intra
VPS52 Q8N1B4 EPM2AIP1 Homo sapiens Q7L775
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 WASHC3 Homo sapiens Q9Y3C0
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 STX11 Homo sapiens O75558
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 STX11 Homo sapiens O75558
Y2H Array
25416956
Intra
VPS52 Q8N1B4 STX11 Homo sapiens O75558
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 RAB4A Homo sapiens P20338
Y2H Array
31515488
Intra
VPS52 Q8N1B4 RAB4A Homo sapiens P20338
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 RAB4A Homo sapiens P20338
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 RAB4A Homo sapiens P20338
Y2H Array
25416956
Intra
VPS52 Q8N1B4 FAM161B Homo sapiens Q96MY7
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 VPS28 Homo sapiens Q9UK41
Y2H
21516116
Intra
VPS52 Q8N1B4 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 KLHL42 Homo sapiens Q9P2K6
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 ZNF417 Homo sapiens Q8TAU3
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 CCDC185 Homo sapiens Q8N715
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 CEP19 Homo sapiens Q96LK0
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 FAM50B Homo sapiens Q9Y247
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 USP2 Homo sapiens O75604
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 GPKOW Homo sapiens Q92917
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 SH2D4A Homo sapiens Q9H788
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 SCNM1 Homo sapiens Q9BWG6
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 WTAP Homo sapiens Q15007
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 JAKMIP2 Homo sapiens Q96AA8
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 KIF9 Homo sapiens Q9HAQ2
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 AIRIM Homo sapiens Q9NX04
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 AIRIM Homo sapiens Q9NX04
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 TBC1D22B Homo sapiens Q9NU19
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 TBC1D22B Homo sapiens Q9NU19
Y2H Array
29892012
Intra
VPS52 Q8N1B4 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
25416956
Intra
VPS52 Q8N1B4 TBC1D22B Homo sapiens Q9NU19
Validated Y2H
32296183
Intra
VPS52 Q8N1B4 TCEANC Homo sapiens Q8N8B7
Y2H Prey Pooling
25416956
Intra
VPS52 Q8N1B4 TCEANC Homo sapiens Q8N8B7
Validated Y2H
25416956
Cross
VPS52 Q8N1B4 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Y2H Prey Pooling
18985028
Cross
VPS52 Q8N1B4 Q9WMX2-PRO_0000037551 Hepatitis C virus Q9WMX2-PRO_0000037551
Pull Down
18985028
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Pontocerebellar Hypoplasia, Type 2e

Pontocerebellar Hypoplasia Type 2

Pontocerebellar Hypoplasia Type 2e

Pch2

PCH2E

Progressive Microcephaly From Birth Extrapyramidal Dyskinesia Chorea Epilepsy

Pontocerebellar Hypoplasia 2e

Pcca2

Progressive Cerebello-Cerebral Atrophy Type 2

Doid:0112328

Hypoplasia, Pontocerebellar, Type 2e

Pontocerebellar Hypoplasia, Type 2d

Pontocerebellar Hypoplasia Type 2a
Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15697 VPS52 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus VPS52 VGNC VGNC:36828
Canis familiaris VPS52 VGNC VGNC:48296
Macaca mulatta VPS52 VGNC VGNC:78551
Mus musculus VPS52 MGD MGI:1330304
Rattus norvegicus VPS52 RGD RGD:3618