Lpar2 - lysophosphatidic acid receptor 2 Gene

Mus musculus

Also known as Edg4; IPA2; LPA2

Gene ID: 53978 | Gene type: protein coding

About Lpar2

Chromosome 8: 70,275,079-70,283,752 forward strand.GRCm39:CM001001.3

This gene has 3 transcripts (splice variants), 270 orthologues, 18 paralogues and is associated with 10 phenotypes. Ubiquitous expression in testis adult (RPKM 4.), spleen adult (RPKM 3.8) and 25 other tissues.

Summary

Enables PDZ domain binding activity. Acts upstream of or within G protein-coupled receptor signaling pathway; positive regulation of MAPK cascade; and positive regulation of Rho protein signal transduction. Located in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; hemolymphoid system gland; and sensory organ. Orthologous to human LPAR2 (lysophosphatidic acid receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Lpar2 Products(1)

mRNA	Protein	Name
NM_020028.3	NP_064412.2	lysophosphatidic acid receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables PDZ domain binding	IPI IPI: Inferred from physical interaction	15755723	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15755723	MGI
acts upstream of or within positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	15755723	MGI
acts upstream of or within positive regulation of Rho protein signal transduction	IDA IDA: Inferred from direct assay	15755723	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19766573	MGI
is active in presynaptic active zone membrane	IDA IDA: Inferred from direct assay	19766573	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Lpar2 Protein Structure

7tm_GPCRs

0
100
200
300
348 a.a.

Protein Preferred Names

Protein Names

lysophosphatidic acid receptor 2

LPA receptor 2	LPA-2
endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor 4	lysophosphatidic acid receptor Edg-4

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107616	H2L5186303	Antagonist	98.72%	Unkown
HY-100676	GRI977143	Agonist	99.84%	Unkown
HY-118539	NSC12404	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lpar2	NCBI	NCBI:9170

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