LPAR2 - lysophosphatidic acid receptor 2 Gene

Homo sapiens

Also known as EDG4; LPA2; EDG-4; LPA-2

Gene ID: 9170 | Gene type: protein coding

About LPAR2

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,623,655-19,628,529 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 18 paralogues. Broad expression in testis (RPKM 11.9), bone marrow (RPKM 11.1) and 22 other tissues.

Summary

This gene encodes a member of family I of the G protein-coupled receptors, as well as the EDG family of proteins. This protein functions as a lysophosphatidic acid (LPA) receptor and contributes to Ca2+ mobilization, a critical cellular response to LPA in cells, through association with Gi and Gq proteins. An alternative splice variant has been described but its full length sequence has not been determined. [provided by RefSeq, Jul 2008]

LPAR2 Products(7)

mRNA	Protein	Name
NM_001395660.1	NP_001382589.1	lysophosphatidic acid receptor 2
XM_017027469.2	XP_016882958.1	lysophosphatidic acid receptor 2 isoform X1
NM_004720.7
XM_024451774.2	XP_024307542.1	lysophosphatidic acid receptor 2 isoform X1
XM_047439678.1	XP_047295634.1	lysophosphatidic acid receptor 2 isoform X1
XM_017027468.3	XP_016882957.1	lysophosphatidic acid receptor 2 isoform X1
XM_047439679.1	XP_047295635.1	lysophosphatidic acid receptor 2 isoform X1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14688263	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	19306925	GOA
colocalizes with endocytic vesicle	IDA IDA: Inferred from direct assay	19306925	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LPAR2 Protein Structure

7tm_1

0
100
200
300
351 a.a.

Protein Preferred Names

Protein Names

lysophosphatidic acid receptor 2

G protein-coupled receptor	LPA receptor 2
LPA receptor EDG4	endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
lysophosphatidic acid receptor EDG4	lysophosphatidic acid receptor Edg-4

LPAR2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LPAR2	Q9HBW0	NHERF2	Homo sapiens	Q15599	Pull Down	16203867
Intra	LPAR2	Q9HBW0	LGALS3	Homo sapiens	P17931	Anti Tag CoIP	28514442
Intra	LPAR2	Q9HBW0	LGALS3	Homo sapiens	P17931	Anti Tag CoIP	33961781
Intra	LPAR2	Q9HBW0	CFTR	Homo sapiens	P13569	Crosslink	16203867

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Secretory Diarrhea

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Epithelial Ovarian Cancer
Neoplasm Of Ovary	Ovarian Neoplasms
Ovarian Cancers	Malignant Neoplasm Of Ovary
Primary Malignant Neoplasm Of Ovary	Ovarian Cancer, Somatic
Malignant Ovarian Tumor	Ovary Neoplasm
Primary Ovarian Cancer	Tumor Of The Ovary
Cancer Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-107616	H2L5186303	Antagonist	98.72%	Unkown
HY-100676	GRI977143	Agonist	99.84%	Unkown
HY-118539	NSC12404	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	LPAR2	VGNC	VGNC:30956
Felis catus	LPAR2	VGNC	VGNC:63262
Mus musculus	LPAR2	MGD	MGI:1858422
Rattus norvegicus	LPAR2	RGD	RGD:1561336
Canis familiaris	LPAR2	VGNC	VGNC:42743
Macaca mulatta	LPAR2	VGNC	VGNC:74409

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