Car2 - carbonic anhydrase 2 Gene

Rattus norvegicus

Also known as Ca2

Gene ID: 54231 | Gene type: protein coding

About Car2

Primary_assembly 2: 86,741,626-86,756,818 reverse strand.mRatBN7.2:CM026975.1

This gene has 2 transcripts (splice variants), 285 orthologues, 16 paralogues and is associated with 11 phenotypes. Biased expression in Spleen (RPKM 2474.6), Kidney (RPKM 1633.5) and 3 other tissues.

Summary

Enables carbonate dehydratase activity. Involved in several processes, including positive regulation of bone resorption; positive regulation of cellular pH reduction; and positive regulation of osteoclast differentiation. Located in several cellular components, including apical part of cell; basolateral plasma membrane; and microvillus. Human ortholog(s) of this gene implicated in autosomal recessive osteopetrosis 3 and osteopetrosis. Orthologous to human CA2 (Carbonic Anhydrase 2). [provided by Alliance of Genome Resources, Apr 2022]

Car2 Products(1)

mRNA	Protein	Name
NM_019291.1	NP_062164.1	carbonic anhydrase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables carbonate dehydratase activity	IDA IDA: Inferred from direct assay	6425289	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10350214	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to fluid shear stress	IEP IEP: Inferred from expression pattern	16777439	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	23869188	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	9655354	RGD
involved in odontogenesis of dentin-containing tooth	IEP IEP: Inferred from expression pattern	8766158	RGD
involved in positive regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	8674544	RGD
involved in positive regulation of cellular pH reduction	IMP IMP: Inferred from mutant phenotype	9665810	RGD
involved in positive regulation of osteoclast differentiation	IMP IMP: Inferred from mutant phenotype	10523502	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	16188437	RGD
involved in response to formaldehyde	IEP IEP: Inferred from expression pattern	17285311	RGD
involved in response to pH	IEP IEP: Inferred from expression pattern	8141264	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	1903702	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	16140947	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	2129509	RGD
located in axon	IDA IDA: Inferred from direct assay	3110266	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16575514	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	102414	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	14644548	RGD
located in microvillus	IDA IDA: Inferred from direct assay	16575514	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Car2 Protein Structure

alpha_CA

0
100
200
260 a.a.

Protein Preferred Names

Protein Names

carbonic anhydrase 2

CA-II	carbonate dehydratase II
carbonic anhydrase II

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01909	Car2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01910	Car2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01934	CARS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

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