Cltc - clathrin heavy chain Gene

Rattus norvegicus

Gene ID: 54241 | Gene type: protein coding

About Cltc

Summary

Enables several functions, including ankyrin binding activity; heat shock protein binding activity; and protein C-terminus binding activity. Involved in Golgi organization; endocytosis; and mitotic cell cycle. Located in T-tubule and spindle. Part of clathrin coat. Is extrinsic component of synaptic vesicle membrane. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Apr 2022]

Cltc Products(1)

mRNA	Protein	Name
NM_019299.2	NP_062172.2	clathrin heavy chain 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ankyrin binding	IDA IDA: Inferred from direct assay	10585476	RGD
enables heat shock protein binding	IDA IDA: Inferred from direct assay	17978091	RGD
enables peptide binding	IDA IDA: Inferred from direct assay	1490999	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11102472	RGD
enables protein serine/threonine kinase binding	IPI IPI: Inferred from physical interaction	20802490	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi organization	IMP IMP: Inferred from mutant phenotype	17065556	RGD
involved in mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	15858577	RGD
involved in receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	15858577	RGD
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	16982422	RGD
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	16982422	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	7536412	RGD
part of clathrin coat	IDA IDA: Inferred from direct assay	1490999	RGD
is active in extrinsic component of synaptic vesicle membrane	IDA IDA: Inferred from direct assay	1325974	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	7536412	RGD
located in spindle	IDA IDA: Inferred from direct assay	15858577	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

clathrin heavy chain 1

clathrin, heavy chain (Hc)

clathrin, heavy polypeptide (Hc)

Cltc Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Cltc	P11442	OCRL	Homo sapiens	Q01968	Pull Down	19536138

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02845	CLTC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cltc	NCBI	NCBI:1213

Name
Email *

	Sorry, but the email address you supplied was invalid.