WDR44 - WD repeat domain 44 Gene

Homo sapiens

Also known as RPH11; SYM-4; RAB11BP

Gene ID: 54521 | Gene type: protein coding

About WDR44

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:118,346,073-118,449,961 (from NCBI)

This gene has 5 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in gall bladder (RPKM 7.8), testis (RPKM 7.1) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

WDR44 Products(3)

mRNA	Protein	Name
NM_001184965.2	NP_001171894.1	WD repeat-containing protein 44 isoform 2
NM_001184966.1	NP_001171895.1	WD repeat-containing protein 44 isoform 3
NM_019045.5	NP_061918.3	WD repeat-containing protein 44 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables molecular sequestering activity	IMP IMP: Inferred from mutant phenotype	31204173	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31204173	GOA
enables small GTPase binding	IDA IDA: Inferred from direct assay	31204173	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cytosolic ciliogenesis	IMP IMP: Inferred from mutant phenotype	31204173	GOA
involved in negative regulation of cilium assembly	IMP IMP: Inferred from mutant phenotype	31204173	GOA
involved in regulation of vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	31204173	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endosome membrane	IDA IDA: Inferred from direct assay	32344433	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR44 Protein Structure

WD40

0
200
400
600
800
913 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 44

rabphilin-11

WDR44 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDR44	Q5JSH3	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	WDR44	Q5JSH3	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	WDR44	Q5JSH3	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15780	WDR44 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	WDR44	VGNC	VGNC:67033
Canis familiaris	WDR44	VGNC	VGNC:48368
Rattus norvegicus	WDR44	RGD	RGD:727965
Bos taurus	WDR44	VGNC	VGNC:36900
Mus musculus	WDR44	MGD	MGI:1919654
Macaca mulatta	WDR44	VGNC	VGNC:79853

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