WDR74 - WD repeat domain 74 Gene

Homo sapiens

Also known as Nsa1

Gene ID: 54663 | Gene type: protein coding

About WDR74

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,832,905-62,841,809 (from NCBI)

This gene has 17 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in bone marrow (RPKM 9.1), ovary (RPKM 4.9) and 25 other tissues.

Summary

Involved in rRNA processing and ribosomal large subunit biogenesis. Located in nucleoplasm. Colocalizes with nuclear exosome (RNase complex) and nucleolus. [provided by Alliance of Genome Resources, Apr 2022]

WDR74 Products(8)

mRNA	Protein	Name
NM_001307977.1	NP_001294906.1	WD repeat-containing protein 74 isoform 2
NM_001369447.1	NP_001356376.1	WD repeat-containing protein 74 isoform 3
NM_001369448.1	NP_001356377.1	WD repeat-containing protein 74 isoform 4
NM_001369449.1	NP_001356378.1	WD repeat-containing protein 74 isoform 4
NM_001369450.1	NP_001356379.1	WD repeat-containing protein 74 isoform 1
NM_001369451.1	NP_001356380.1	WD repeat-containing protein 74 isoform 1
NM_001369453.1	NP_001356382.1	WD repeat-containing protein 74 isoform 1
NM_018093.3	NP_060563.2	WD repeat-containing protein 74 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in rRNA processing	IMP IMP: Inferred from mutant phenotype	29107693	GOA
involved in ribosomal large subunit biogenesis	IMP IMP: Inferred from mutant phenotype	26456651	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of nuclear exosome (RNase complex)	IDA IDA: Inferred from direct assay	26456651	GOA
colocalizes with nucleolus	IDA IDA: Inferred from direct assay	26456651	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	12429849	GOA
located in nucleolus	IMP IMP: Inferred from mutant phenotype	29107693	GOA
located in nucleus	IDA IDA: Inferred from direct assay	28416111	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR74 Protein Structure

WD40

0
100
200
300
385 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 74

NOP seven-associated protein 1

WDR74 Protein-protein interaction Information

Type Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDR74	Q6RFH5	RCHY1	Homo sapiens	Q96PM5	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Lateral Ventricle Meningioma

Meningioma Of The Lateral Ventricle

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect Pre-designed Sets	Purity	Rare Diseases Unkown
HY-RS15795	WDR74 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	WDR74	VGNC	VGNC:48386
Felis catus	WDR74	VGNC	VGNC:67053
Bos taurus	WDR74	VGNC	VGNC:36918
Rattus norvegicus	WDR74	RGD	RGD:1582881
Macaca mulatta	WDR74	VGNC	VGNC:79509
Mus musculus	WDR74	MGD	MGI:2147427

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